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This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected

 
Face Palmer
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This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
Here's proof of how far we've come in science - in June 2017, researchers recorded up-close footage of a single DNA molecule replicating itself for the first time, and it's raised questions about how we assumed the process played out.

The real-time footage revealed that this fundamental part of life incorporates an unexpected amount of 'randomness', and it could force a major rethink into how genetic replication occurs without mutations.

"It's a real paradigm shift, and undermines a great deal of what's in the textbooks," said one of the team, Stephen Kowalczykowski from the University of California, Davis.

"It's a different way of thinking about replication that raises new questions."

The DNA double helix consists of two intertwining strands of genetic material made up of four different bases - guanine, thymine, cytosine, and adenine (G, T, C and A).

Replication occurs when an enzyme called helicase unwinds and unzips the double helix into two single strands.

A second enzyme called primase attaches a 'primer' to each of these unravelled strands, and a third enzyme called DNA polymerase attaches at this primer, and adds additional bases to form a whole new double helix.

You can watch that process in the 2017 footage below:

[link to www.sciencealert.com (secure)]
"The world will soon wake up to the reality that everyone is broke and can collect nothing from the bankrupt, who are owed unlimited amounts by the insolvent, who are attempting to make late payments on a bank holiday in the wrong country, with an unacceptable currency, against defaulted collateral, of which nobody is sure who holds title."

Never attribute to malice that which is adequately explained by stupidity.

The woman who is not pursued sets up the doctrine that pursuit is offensive to her sex, and wants to make it a felony. No genuinely attractive woman has any such desire. - H.L. Mencken, In Defense Of Women
BRIEF

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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
The "randomness" is where diseases come from, genetic defects that allow us to get sick.
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I am a licensed firearm holder. I will, under protection of law, use lethal force if attacked.

Briefcut4892
Face Palmer  (OP)

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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
The "randomness" is where diseases come from, genetic defects that allow us to get sick.
 Quoting: BRIEF


Yeah but also the good changes come from randomness
"The world will soon wake up to the reality that everyone is broke and can collect nothing from the bankrupt, who are owed unlimited amounts by the insolvent, who are attempting to make late payments on a bank holiday in the wrong country, with an unacceptable currency, against defaulted collateral, of which nobody is sure who holds title."

Never attribute to malice that which is adequately explained by stupidity.

The woman who is not pursued sets up the doctrine that pursuit is offensive to her sex, and wants to make it a felony. No genuinely attractive woman has any such desire. - H.L. Mencken, In Defense Of Women
Anonymous Coward
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03/06/2018 06:29 AM
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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
Assumptions were wrong. Scientists are baffled, lol.
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03/06/2018 07:20 AM

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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
The "randomness" is where diseases come from, genetic defects that allow us to get sick.
 Quoting: BRIEF


Yeah but also the good changes come from randomness
 Quoting: Face Palmer


Most mutations are disastrous but yes, there is the environment for change and it supports micro-evolution at least.
Dog kicker

I never forgive and I never forget

I am a licensed firearm holder. I will, under protection of law, use lethal force if attacked.

Briefcut4892
Face Palmer  (OP)

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03/06/2018 07:45 AM
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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
bump
"The world will soon wake up to the reality that everyone is broke and can collect nothing from the bankrupt, who are owed unlimited amounts by the insolvent, who are attempting to make late payments on a bank holiday in the wrong country, with an unacceptable currency, against defaulted collateral, of which nobody is sure who holds title."

Never attribute to malice that which is adequately explained by stupidity.

The woman who is not pursued sets up the doctrine that pursuit is offensive to her sex, and wants to make it a felony. No genuinely attractive woman has any such desire. - H.L. Mencken, In Defense Of Women
Anonymous Coward
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03/06/2018 07:57 AM
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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
The "randomness" is where diseases come from, genetic defects that allow us to get sick.
 Quoting: BRIEF


Yeah but also the good changes come from randomness
 Quoting: Face Palmer


No, the changes are not good. They may appear to be good only because they have partially reversed a bad change that had occurred in the past.
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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
The "randomness" is where diseases come from, genetic defects that allow us to get sick.
 Quoting: BRIEF


Yeah but also the good changes come from randomness
 Quoting: Face Palmer


No, the changes are not good. They may appear to be good only because they have partially reversed a bad change that had occurred in the past.
 Quoting: Anonymous Coward 69656997


The planet changes and so must we on the micro level...
Dog kicker

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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
I don't believe in randomness.

I believe in level of resolution. Random is just a result from a solid process we don't understand or can't witness.


Forces we don't understand are guiding DNA replication.
Redcat1

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03/06/2018 08:06 AM
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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
"God does not play dice with the Universe." - A.E.


Its likely that things are not as random as they look.
The Deplorable JP Warchild

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03/06/2018 08:19 AM
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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
There are many error correcting mechanisms that come into play after the initial replication process. Error correction enzymes.
Anonymous Coward
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03/06/2018 08:24 AM
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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
I don't believe in randomness.

I believe in level of resolution. Random is just a result from a solid process we don't understand or can't witness.


Forces we don't understand are guiding DNA replication.
 Quoting: -VonAmoR-


I know they have ways to jack with it. Not good...
-VonAmoR-

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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
As well, we found that the folding of DNA is also a pattern itself that is used to synthesis different proteins, etc.

DNA has the code for everything we need. The way it folds up is how it determines which gene is turned on or off.

If injected DNA can be engineered to attach to a specific sequence, then the processes in the cell can be altered. A way to specifically turn on/off certain genes. Just by blanketing the DNA sequence with injected material that attaches to the DNA.
Innocentfishingboat

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03/06/2018 10:05 AM
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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
If there is a code, there are a variety of sequences, not randomness.

It should read that scientist's have not deciphered these sequences that, at present time, appears random.

Randomness in DNA sequencing is an oxymoran at best and that's Biology 101.
I didn't mean to do that...or did I?
Face Palmer  (OP)

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03/06/2018 10:26 AM
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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
Soon.
"The world will soon wake up to the reality that everyone is broke and can collect nothing from the bankrupt, who are owed unlimited amounts by the insolvent, who are attempting to make late payments on a bank holiday in the wrong country, with an unacceptable currency, against defaulted collateral, of which nobody is sure who holds title."

Never attribute to malice that which is adequately explained by stupidity.

The woman who is not pursued sets up the doctrine that pursuit is offensive to her sex, and wants to make it a felony. No genuinely attractive woman has any such desire. - H.L. Mencken, In Defense Of Women
cosmicgypsy

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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
Fascinating!


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under wandering stars I've grown,
by myself, but not alone...

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When North Korea is easier to negotiate with than the democrat party, then something is horribly wrong with them.--Zedakah, GLP member

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Anonymous Coward
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03/06/2018 10:40 AM
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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
The most important rule in science goes as follows:

Occam's Razor: when presented with competing hypothetical answers to a problem, one should select the one that makes the fewest assumptions.

Occam's Razor will be true in:
physics if we rule out quantum physics,
chemistry if we rule out organic chemistry,
biology if we rule out, well, biology,
forensic science if we rule out human behavior,
history if we...

Wait a minute here. Let's start again:

Occam's Razor will be true on TV and in Science Fiction.
Anonymous Coward
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03/06/2018 10:44 AM
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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
Wait, What? Its more complicated that we thought? There must be random shit going on, damnit! If we can't figure it out, its got to be random!
Seer777
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03/06/2018 10:53 AM

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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
Here's proof of how far we've come in science - in June 2017, researchers recorded up-close footage of a single DNA molecule replicating itself for the first time, and it's raised questions about how we assumed the process played out.

The real-time footage revealed that this fundamental part of life incorporates an unexpected amount of 'randomness', and it could force a major rethink into how genetic replication occurs without mutations.

"It's a real paradigm shift, and undermines a great deal of what's in the textbooks," said one of the team, Stephen Kowalczykowski from the University of California, Davis.

"It's a different way of thinking about replication that raises new questions."

The DNA double helix consists of two intertwining strands of genetic material made up of four different bases - guanine, thymine, cytosine, and adenine (G, T, C and A).

Replication occurs when an enzyme called helicase unwinds and unzips the double helix into two single strands.

A second enzyme called primase attaches a 'primer' to each of these unravelled strands, and a third enzyme called DNA polymerase attaches at this primer, and adds additional bases to form a whole new double helix.

You can watch that process in the 2017 footage below:

[link to www.sciencealert.com (secure)]
 Quoting: Face Palmer

Tiny organic machines?


Have you seen this? This is happening in all of us at a rate the mind can't begin to grasp on conscious level.

It is said that 'real time' is a bit faster and I find that fascinating:

The Protein Molecular Machines at Work in DNA Copying
[link to imgur.com]
 Quoting: Seer777


Watch it again. Just watch it. Look how perfect it is. ^^^

That is what I think of, when I think of 'Intelligent design'.
 Quoting: Seer777


Great place for my favorite gif.

coffee4
Difficulties strengthen the Mind as labor does the body...
~Seneca
Seer777
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03/06/2018 11:00 AM

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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
Here's proof of how far we've come in science - in June 2017, researchers recorded up-close footage of a single DNA molecule replicating itself for the first time, and it's raised questions about how we assumed the process played out.

The real-time footage revealed that this fundamental part of life incorporates an unexpected amount of 'randomness', and it could force a major rethink into how genetic replication occurs without mutations.

"It's a real paradigm shift, and undermines a great deal of what's in the textbooks," said one of the team, Stephen Kowalczykowski from the University of California, Davis.

"It's a different way of thinking about replication that raises new questions."

The DNA double helix consists of two intertwining strands of genetic material made up of four different bases - guanine, thymine, cytosine, and adenine (G, T, C and A).

Replication occurs when an enzyme called helicase unwinds and unzips the double helix into two single strands.

A second enzyme called primase attaches a 'primer' to each of these unravelled strands, and a third enzyme called DNA polymerase attaches at this primer, and adds additional bases to form a whole new double helix.

You can watch that process in the 2017 footage below:

[link to www.sciencealert.com (secure)]
 Quoting: Face Palmer

Tiny organic machines?


Have you seen this? This is happening in all of us at a rate the mind can't begin to grasp on conscious level.

It is said that 'real time' is a bit faster and I find that fascinating:

The Protein Molecular Machines at Work in DNA Copying
[link to imgur.com]
 Quoting: Seer777


Watch it again. Just watch it. Look how perfect it is. ^^^

That is what I think of, when I think of 'Intelligent design'.
 Quoting: Seer777


Great place for my favorite gif.

coffee4
 Quoting: Seer777


For clarity on the gif.

Helicase: bright blue...unwinds DNA at about the speed of a jet engine. Polymerase: purple...copies DNA strands.
~chemistrydoc
Difficulties strengthen the Mind as labor does the body...
~Seneca
Anonymous Coward
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03/06/2018 11:07 AM
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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
The "randomness" is where diseases come from, genetic defects that allow us to get sick.
 Quoting: BRIEF



you've seen Dr. Bruce Lipton's "Biology of Belief" haven't you?

the DNA has aspects that change based on environment and beliefs...

thus you break the laws here--aka sodomy--and you may have a son who is gay.
assmaster tittyfish supreme
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03/06/2018 11:16 AM
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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
"The researchers also found that because of this lack of coordination, the DNA double helix has had to incorporate a 'dead man's switch', which would kick in and stop the helicase from unzipping any further so that the polymerase can catch up."
Anonymous Coward
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03/06/2018 11:17 AM
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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
Where are they getting this footage? Hmmmm
Scientist do not use the word randfom unless it is a hypothesis
Zedakah

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03/06/2018 11:23 AM

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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
I don't believe in randomness.

I believe in level of resolution. Random is just a result from a solid process we don't understand or can't witness.


Forces we don't understand are guiding DNA replication.
 Quoting: -VonAmoR-


The “randomness” in the article comes from the assumption that enzymes are essentially tiny lifeless machines. Meaning they do a specific job without any consciousness - they are autonomous.

As a Scientist who studies DNA and cells myself, I have always thought enzymes do exhibit a certain level of conscious behavior.

They are truly the link between life and chemicals.

Last Edited by Zedakah on 03/06/2018 11:24 AM
Seer777
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03/06/2018 11:31 AM

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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
Good morning everyone. I like the usage of language in this vid. Cell process being likened to a 'machine' and/or 'factory'.


[link to www.youtube.com]


 Quoting: Seer777

Difficulties strengthen the Mind as labor does the body...
~Seneca
Halcyon Dayz, FCD

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03/06/2018 11:41 AM
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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
"God does not play dice with the Universe." - A.E.
 Quoting: Redcat1

"Albert does not get to tell me what to do." - God.
book
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Hi! My name is Halcyon Dayz and I'm addicted to morans.
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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
I don't believe in randomness.

I believe in level of resolution. Random is just a result from a solid process we don't understand or can't witness.


Forces we don't understand are guiding DNA replication.
 Quoting: -VonAmoR-


The “randomness” in the article comes from the assumption that enzymes are essentially tiny lifeless machines. Meaning they do a specific job without any consciousness - they are autonomous.

As a Scientist who studies DNA and cells myself, I have always thought enzymes do exhibit a certain level of conscious behavior.

They are truly the link between life and chemicals.
 Quoting: Zedakah


It might be a simple conscious piece, a basic "ohm.." like thought that desires the process the cell is after.

Not complex like us, but still alive.


I found it amazing how plants can respond to damage stimulus on the other side of the plant with out direct hormone/chemical interactions. Even other plants.


I also believe DNA acts like an antenna, or something in our body does. And viruses change that antenna tuning to bring in the soul of the virus in the cell.

Might help explain demonic possession. If the tune of the body to the soul was altered, a new soul may try to come in. But not an organized soul, a screwed up one that is not normally incarnated "tuned into" by normal life forms.
Anonymous Coward
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03/06/2018 11:56 AM
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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
"God does not play dice with the Universe." - A.E.


Its likely that things are not as random as they look.
 Quoting: Redcat1


Einstein, stop telling God what to do! -Niels Bohr
-VonAmoR-

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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
I don't believe in randomness.

I believe in level of resolution. Random is just a result from a solid process we don't understand or can't witness.


Forces we don't understand are guiding DNA replication.
 Quoting: -VonAmoR-


The “randomness” in the article comes from the assumption that enzymes are essentially tiny lifeless machines. Meaning they do a specific job without any consciousness - they are autonomous.

As a Scientist who studies DNA and cells myself, I have always thought enzymes do exhibit a certain level of conscious behavior.

They are truly the link between life and chemicals.
 Quoting: Zedakah


This may sound crazy (but we are on GLP, lol) but I think life, one of the secrets of, lies in the 6 sided star in ancient history.

two triangles, positive and negative.

Plants express this pattern and they will die if the pattern is broken. But will live if not. The leaf to the stem is where the inverting pattern is.

no leaf to stem, plant dies. But as long as there is leaf to stem (or whatever the inverting point is for the plant in mind) the plant can root.


Take a normal maple leaf. The tip of the leaf is guided to the outside of the plant stem. The furthest edge of the leaf is guided to the inner portion of the stem.

The roots do not invert.

So it is like this.

Tip (focal point) to center to deep root tip (diverse)
Edges (diverse) to outer bark to root outer casing (focal point)

Energy from sky to ground is inverted so the poles can be separated.

Imagine the Star like a clock face. 12 noon (the high point) leads to 8 and 4 (diverse).

6 root focal point goes to 10 and 2, the edge of leaf.


Since the electric charge is inverted, it can be broken from the source/ground and then used.

I believe cells do the same but in a different way. Splitting the charges, inverting them so they can be broken free and then used.


It seems crazy, but look at all life, it has the pattern.

Last Edited by -VonAmoR- on 03/06/2018 11:57 AM
Zedakah

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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
I don't believe in randomness.

I believe in level of resolution. Random is just a result from a solid process we don't understand or can't witness.


Forces we don't understand are guiding DNA replication.
 Quoting: -VonAmoR-


The “randomness” in the article comes from the assumption that enzymes are essentially tiny lifeless machines. Meaning they do a specific job without any consciousness - they are autonomous.

As a Scientist who studies DNA and cells myself, I have always thought enzymes do exhibit a certain level of conscious behavior.

They are truly the link between life and chemicals.
 Quoting: Zedakah


It might be a simple conscious piece, a basic "ohm.." like thought that desires the process the cell is after.

Not complex like us, but still alive.


I found it amazing how plants can respond to damage stimulus on the other side of the plant with out direct hormone/chemical interactions. Even other plants.


I also believe DNA acts like an antenna, or something in our body does. And viruses change that antenna tuning to bring in the soul of the virus in the cell.

Might help explain demonic possession. If the tune of the body to the soul was altered, a new soul may try to come in. But not an organized soul, a screwed up one that is not normally incarnated "tuned into" by normal life forms.
 Quoting: -VonAmoR-


Below is a picture of a virus I took using TEM. A virus is not considered a living organism. Yet, a virus adapts to its environment, it seeks out hosts in order to reproduce, it contains highly complex and purposeful structures.

However, when you define a virus - it is simply a piece of DNA. A virus is just a "rogue" DNA contained in a protein capsule. There is nothing in there that could be classified as life as science defines it, yet it still has a behavior as if it were living.

The same can be said for enzymes and other proteins (think prions).

I've spent years of my life under the microscope watching bacteria, fungi, and other cells live and die. There is some sort of consciousness in those single cells, because all of them avoid dying to the best of their ability.

zedvirus2
-VonAmoR-

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Re: This Is The First Detailed Footage of DNA Replication, And It Wasn't What We Expected
I don't believe in randomness.

I believe in level of resolution. Random is just a result from a solid process we don't understand or can't witness.


Forces we don't understand are guiding DNA replication.
 Quoting: -VonAmoR-


The “randomness” in the article comes from the assumption that enzymes are essentially tiny lifeless machines. Meaning they do a specific job without any consciousness - they are autonomous.

As a Scientist who studies DNA and cells myself, I have always thought enzymes do exhibit a certain level of conscious behavior.

They are truly the link between life and chemicals.
 Quoting: Zedakah


It might be a simple conscious piece, a basic "ohm.." like thought that desires the process the cell is after.

Not complex like us, but still alive.


I found it amazing how plants can respond to damage stimulus on the other side of the plant with out direct hormone/chemical interactions. Even other plants.


I also believe DNA acts like an antenna, or something in our body does. And viruses change that antenna tuning to bring in the soul of the virus in the cell.

Might help explain demonic possession. If the tune of the body to the soul was altered, a new soul may try to come in. But not an organized soul, a screwed up one that is not normally incarnated "tuned into" by normal life forms.
 Quoting: -VonAmoR-


Below is a picture of a virus I took using TEM. A virus is not considered a living organism. Yet, a virus adapts to its environment, it seeks out hosts in order to reproduce, it contains highly complex and purposeful structures.

However, when you define a virus - it is simply a piece of DNA. A virus is just a "rogue" DNA contained in a protein capsule. There is nothing in there that could be classified as life as science defines it, yet it still has a behavior as if it were living.

The same can be said for enzymes and other proteins (think prions).

I've spent years of my life under the microscope watching bacteria, fungi, and other cells live and die. There is some sort of consciousness in those single cells, because all of them avoid dying to the best of their ability.

zedvirus2
 Quoting: Zedakah


Yeah, I believe it.

I may be wrong but, I viewed viruses as automated machinery (of an unknown author) that hijacks living organisms. But with a soul behind it.

Somewhere in the conscious ether, the virus has a soul and is trying to incarnate.

There are probably other instances of foreign souls trying to take over a host. Not just physically by DNA, but by consious intent as well.


Maybe that is how our bodies can detect invaders.





GLP