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Message Subject Are you curious enough to look at Toxoplasma?
Poster Handle just a dude
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Moetics


basement membrane
- collagen
- laminin and fibronectin adhesive glycoproteins (have sugar moetics attached to them)

Glycosylation, the attachment of sugar moieties to proteins

In the anthropological study of kinship, a moiety is a descent group that coexists with only one other descent group within a society. (wiki)

Downfall of moieties

Mo'i/Ali'i

Dodonaea viscosa (Sapindaceae, soapberry family) - hopbush

Leaves: plasters for wounds

Fruit: red dye

The Seri people of the southwest used the plant medicinally for a variety of purposes (but sources are not specific). It was also used to stimulate lactation in mothers, as a dysentery treatment, to cure digestive system disorders, skin problems and rheumatism in Africa and Asia. In New Guinea, people use it as incense for funerals. [link to arizonadailyindependent.com (secure)]


The bark is sometimes used in poultices for swellings and headaches and is added to baths. The leaves have pain-killing, wound healing and diaphoretic (sweat-promoting) qualities as well as being astringent and useful for skin rashes, toothache and sore throats. A decoction or infusion can be made from them and the liquid applied to affected areas of the skin.
...
In some countries the leaves are chewed for their stimulant qualities, although as they contain saponins and the oil in them is cyanogenic, this is not advisable, although I’m told they spit out the leaf having masticated it well.
...
Modern research has shown that the hopbush has potential benefits as the leaves have been found to have anti-fungal, anti-diabetic (in vivo on rats) anti-bacterial, anti-inflammatory anti-oxidant properties. They can also help to combat ulcers. They contain flavonoids and tannins as well as saponins and steroids and triterpenes, but further research is needed to discover exactly which substances have the most active beneficial properties.
[link to herbs-treatandtaste.blogspot.com]


Glycosylation

Glycan linkages

N-Linked glycans are attached in the endoplasmic reticulum to the nitrogen (N) in the side chain of asparagine in the sequon. (wiki)

In eukaryotes, O-linked glycans are assembled one sugar at a time on a serine or threonine residue of a peptide chain in the Golgi apparatus. Unlike N-linked glycans, there is no known consensus sequence yet. However, the placement of a proline residue at either -1 or +3 relative to the serine or threonine is favourable for O-linked glycosylation.

Xylose, fucose, mannose, and GlcNAc phosphoserine glycans have been reported in the literature. Fucose and GlcNAc have been found only in Dictyostelium discoideum, mannose in Leishmania mexicana, and xylose in Trypanosoma cruzi. Mannose has recently been reported in a vertebrate, the mouse, Mus musculus, on the cell-surface laminin receptor alpha dystroglycan4. It has been suggested this rare finding may be linked to the fact that alpha dystroglycan is highly conserved from lower vertebrates to mammals.[11]

Over 40 disorders of glycosylation have been reported in humans.[15] These can be divided into four groups: disorders of protein N-glycosylation, disorders of protein O-glycosylation, disorders of lipid glycosylation and disorders of other glycosylation pathways and of multiple glycosylation pathways. No effective treatment is known for any of these disorders. 80% of these affect the nervous system.



g_the_baptist
 Quoting: just a dude


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Memetics pogrom moetics
 
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