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PEA - Phenethylamine - The Love Drug! Keep The Love Buzz

 
Anonymous Coward
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01/30/2019 06:44 AM
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PEA - Phenethylamine - The Love Drug! Keep The Love Buzz


A strong whiff of armpit pheromones isn't enough
PEA is the 'attraction' chemical... love at first sight... keeping your partner and yourself in PEA keeps relationships a thrill
Anonymous Coward (OP)
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01/30/2019 09:48 AM
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
PEA PRODUCTION AND ACTIVATION

L-phenylalanine is a precursor for PEA. Vitamin B6 is the key nutrient in the production of the beneficial biogenic dopamine and PEA. Vitamin B6 in the form of pyridoxine hydrochloride is biologically inactive. Once B6 enters a cell,enzymatic transfer of the g-phosphoryl group from ATP forms the coenzyme pyridoxal 5’-phosphat, PLP. This conversion to the active form requires magnesium and vitamin B2. PLP is a prostetic group for many enzymeS that catalyze a vareity of reactions involving amino acids. PLP is tightly bound to to the enzyme by many weak noncovalent interactions.

[link to xray.bmc.uu.se]

(snip <50%)


WHAT AFFECTS LOVE?

As difficult as love is to define, its first flickers apparently begin in the prefrontal cortex, the section of your brain that enables you to anticipate the joy of being with a particul person, even one you ever met. If it´s powerful enough, this so called memory of the future engages the ancestral “fight and flight” response of the lower brain, which is responsible for such involuntary functions as stammering, tripping, drooling and laughing too loudly at someone else´s joke.

Endorphines fuel the chemical cocktail. Similar in structure to morphine, endorphines are perhaps best known for creating a blissful sense of calm in long distance runners. They leave lovers feeling similary tranquil, but not in the early going. During the initial stages of attraction, endorphines serve as a catalyst by triggering special cells in the midbrain to produce dopamine and PEA, powerful natural amphetamines. In the boot camp of romance, dopamine and PEA are the drill sergeant. They barks at the brain to select a plan of action, any plan.

(snip <50%)


SIMILARITY BETWEEN PEA AND AMPHETAMINE:

Picture of Amphetamine Picture of Phenylethylamine
Amfetamine Phenylethylamine

As we can see PEA and amphetamine are very similar to each other. Some of the effects of amphetamine is increased energy, enhanced awakeness, less appetite, increased breathe and heart rate. Do you recognize this? It seems to be the same effects as that of PEA when we fall in love. An overcosumption of amphetamine and overproduktion of PEA leads to paranoia.





Does PEA affect other animals?

It's recently been discovered that carnivorous animals such as lions and tigers have much higher levels of PEA than herbivores, sometimes 3,000 times as much. American scientists first isolated it from the urine of bobcats (photo, left), which is used by American gardeners to scare off rodents and rabbits. They found that it activates one of the mouse's trace amine-associated receptors (TAAR4), making the mice (and rats) take avoiding action by triggering their aversion circuits. Rodents avoided lion's urine, but not when the phenylethylamine had been removed from it. It may well be that the phenylethylamine levels in carnivores are a product of breakdown of meat proteins, which would be a source of phenylalanine. And it is also possible that Jerry Mouse lacks the important TAAR4 gene.

[link to www.chm.bris.ac.uk]


snip <50%
Anonymous Coward
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01/30/2019 09:52 AM
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
PEA PRODUCTION AND ACTIVATION

L-phenylalanine is a precursor for PEA. Vitamin B6 is the key nutrient in the production of the beneficial biogenic dopamine and PEA. Vitamin B6 in the form of pyridoxine hydrochloride is biologically inactive. Once B6 enters a cell,enzymatic transfer of the g-phosphoryl group from ATP forms the coenzyme pyridoxal 5’-phosphat, PLP. This conversion to the active form requires magnesium and vitamin B2. PLP is a prostetic group for many enzymeS that catalyze a vareity of reactions involving amino acids. PLP is tightly bound to to the enzyme by many weak noncovalent interactions.

[link to xray.bmc.uu.se]

(snip <50%)


WHAT AFFECTS LOVE?

As difficult as love is to define, its first flickers apparently begin in the prefrontal cortex, the section of your brain that enables you to anticipate the joy of being with a particul person, even one you ever met. If it´s powerful enough, this so called memory of the future engages the ancestral “fight and flight” response of the lower brain, which is responsible for such involuntary functions as stammering, tripping, drooling and laughing too loudly at someone else´s joke.

Endorphines fuel the chemical cocktail. Similar in structure to morphine, endorphines are perhaps best known for creating a blissful sense of calm in long distance runners. They leave lovers feeling similary tranquil, but not in the early going. During the initial stages of attraction, endorphines serve as a catalyst by triggering special cells in the midbrain to produce dopamine and PEA, powerful natural amphetamines. In the boot camp of romance, dopamine and PEA are the drill sergeant. They barks at the brain to select a plan of action, any plan.

(snip <50%)


SIMILARITY BETWEEN PEA AND AMPHETAMINE:

Picture of Amphetamine Picture of Phenylethylamine
Amfetamine Phenylethylamine

As we can see PEA and amphetamine are very similar to each other. Some of the effects of amphetamine is increased energy, enhanced awakeness, less appetite, increased breathe and heart rate. Do you recognize this? It seems to be the same effects as that of PEA when we fall in love. An overcosumption of amphetamine and overproduktion of PEA leads to paranoia.





Does PEA affect other animals?

It's recently been discovered that carnivorous animals such as lions and tigers have much higher levels of PEA than herbivores, sometimes 3,000 times as much. American scientists first isolated it from the urine of bobcats (photo, left), which is used by American gardeners to scare off rodents and rabbits. They found that it activates one of the mouse's trace amine-associated receptors (TAAR4), making the mice (and rats) take avoiding action by triggering their aversion circuits. Rodents avoided lion's urine, but not when the phenylethylamine had been removed from it. It may well be that the phenylethylamine levels in carnivores are a product of breakdown of meat proteins, which would be a source of phenylalanine. And it is also possible that Jerry Mouse lacks the important TAAR4 gene.

[link to www.chm.bris.ac.uk]


snip <50%
 Quoting: Wotsits


amazing what nature does isn't it... and the complexity of the meat suit humans wear.

:Thankyou Happy F:
Anonymous Coward (OP)
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01/30/2019 09:56 AM
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
Glad you liked it! Good luck bio-hacking!



Seems this is the key:



and BASIL!

which goes to explain the world renowned British virilitydamned
Anonymous Coward
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01/30/2019 10:11 AM
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
mescaline, MDMA, and bromo-dragonfly are phenethylamine derivatives :D

love drug is no joke :P
Anonymous Coward (OP)
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01/30/2019 10:23 AM
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
mescaline, MDMA, and bromo-dragonfly are phenethylamine derivatives :D

love drug is no joke :P
 Quoting: Deafcat


Sure! no joke! However my biochemist friend warns me that external introduction of transmitters lead to a reduction in the body's own production ---> comedowns etc

so need to boost it naturally...

and that aint gonna happen without B vits



need to research MAO Inhibitor Activity


[link to thesunlightexperiment.com (secure)]

Why We Should Be Interested in Natural MAO Inhibitors
MAO stands for monoamine oxidase.

It's an enzyme that breaks down certain neurotransmitters in the brain like dopamine, serotonin, and dimethyltryptamine. All of which are crucial to brain function in various ways.

There are actually 2 types of MAO in the body, and although similar, have different preferences for the monoamines they break down (deaminate). MAO-A, and MAO-B.

Inhibiting this enzyme slow the breakdown of neurotransmitters, allowing their numbers to increase.





Looks like Licorice Root (Glycyrrhiza Glabra) is the most palatable, although 5. Turmeric (Curcuma Longa) is high too!



so date night looks like:





- Beefy broth/marmite with lashings of basil or a curry
- Licorice sweets

- followed by chocolate for good measure

bananasex
Anonymous Coward
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01/30/2019 10:25 AM
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
Why We Should Be Interested in Natural MAO Inhibitors
MAO stands for monoamine oxidase.
 Quoting: Wotsits


banisteriopsis caapi (ayahuasca vine) and passiflora incarnata are my favorite of those

hf


funny how the most potent of the things you're talking about are hallucinogens, eh?

what is love?
Anonymous Coward (OP)
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01/30/2019 10:29 AM
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
Why We Should Be Interested in Natural MAO Inhibitors
MAO stands for monoamine oxidase.
 Quoting: Wotsits


banisteriopsis caapi (ayahuasca vine) and passiflora incarnata are my favorite of those

hf


funny how the most potent of the things you're talking about are hallucinogens, eh?

what is love?
 Quoting: Deafcat


row row row your boat... float
Thank you Sensei.cheers

Will get some Passionfruit tea
Anonymous Coward
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01/30/2019 10:48 AM
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
not passionfruit, passionflower :)

i used to keep extract of it as a tincture for sublingual dosing in case of panic attacks - would usually start working after about 60 seconds, then would swallow

one sec, gonna upload some pics of mine, just cause... they be pretty and shit too :)
Desert Storm Paratrooper 71L

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01/30/2019 11:30 AM
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
Be careful with PEA, I tried some once as a "pre-workout" before going to the gym -- 500mg on an empty stomach -- the effects were not pleasant.
Anonymous Coward
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01/30/2019 11:36 AM
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
passiflora lutea - interesting the 'tea' synch... we don't have these here (here being indiana), this was at zilker gardens in austin, tx - they host gulf fritillary caterpillars, which we don't have here either :'/

:lutea343:

the incarnatas we have here though :)

:incarnata343:


gotta have a frickin flower to give for a date night eh... i'm particular to orchids, but a lady can't really wear 'em well, most a pity... if you happen to be lucky and be datin' one of the dark-minded, freaky ones, she'd probably like these ones :Þ and if she gets hungry and decides to eat the flower, all the better :)
Anonymous Coward
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01/30/2019 03:34 PM
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
Thanks guys, I have homework to do on this...

Wife and I have symptoms of a 'ten year itch'

but I'm not too worried

wine coolers and chocolate are instant remedies... but gotta work on my Vits and PEA pathways...

captain

dasbier
Psychonaut SN7

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01/30/2019 03:41 PM
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
mescaline, MDMA, and bromo-dragonfly are phenethylamine derivatives :D

love drug is no joke :P
 Quoting: Deafcat


They are Substituted Phenethylamines...

Last Edited by COSMIC WARRIOR on 01/30/2019 03:43 PM
"The syntactical nature of reality, the real secret of magic, is that the world is made of words. And if you know the words that the world is made of, you can make of it whatever you wish."

~ Terence McKenna
Anonymous Coward
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01/30/2019 03:47 PM
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
Mmmmmmmmm....

Chocolate.

smile_kiss
Anonymous Coward
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01/30/2019 05:27 PM
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
Mmmmmmmmm....

Chocolate.

smile_kiss
 Quoting: LittleMissDictator


Chocolate coated Passionflowers!
smile_kiss

Anonymous Coward
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01/30/2019 05:28 PM
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
hrm...gotta be getting me some of this synthetic love
Hillarys_Dirty_Diaper​

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01/30/2019 05:40 PM
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
What do you need to eat or supplement with?

Entire thread doesn't really explain...

Vitamin B6? What else? Chocolate???
"Run. Run hard, run now, run silent, run deep. Run like Mexican water through a first time tourist, but the key word here is: RUN!"
- Al Bundy
Anonymous Coward
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01/30/2019 06:25 PM
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
What do you need to eat or supplement with?

Entire thread doesn't really explain...

Vitamin B6? What else? Chocolate???
 Quoting: Hillarys_Dirty_Diaper


1 : B6, B2 and then an inhibitor to allow for PEA to accumulate.

I think the one you need for PEA is:

2 : Monoamine oxidase B "MAOB"

Sounds like it's dangerous to go synthetic here, so natural ones are things like Passionflower - Licorice - Ayahuasca etc

see: [link to www.livestrong.com (secure)]



also you'll need a source of Phenylalanine which converts to PEA with the vits above


3 : CHOCOLATE/Cocoa is a source!

but generally meats/dairy/protein.... and herbs like basil





B Vits are key. (smoking depletes this btw)
[link to www.dailymail.co.uk (secure)]

Happy little Vegemite! Yeast-based spreads found to help people feel less anxious and reduce stress
Research has found yeast spreads can help reduce anxious feelings and stress
Professor from the University of Victoria said spreads with B12 were best to eat
These included Marmite and My First Vegemite, which has an orange lid
Professor Vasso Apostolopoulos says B vitamins are good for moderating stress
Anonymous Coward
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
[link to www.mirror.co.uk (secure)]

A doctor who tested the pills, which generated more than £10million a year for John of God, found they were simple passionflower herbal supplements.

Thread: Sex slave ringleader, baby trafficker, and mass murdering faith healer tied to the Clintons, Oprah, and a whole host of Celebrities

wtf
Anonymous Coward (OP)
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02/04/2019 08:42 AM
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
MAO-B inhibitor and ancient cure-all! Credited as having saved India from the Great Flu Pandemic



Good news for me as I swear by this stuff to cure just about any cold and flu/malaria... (and cured me of Dengue fever!) and have a stock of it.


Ancient herb widely used in Asia...
and sold in every 7-11 store in Thailand:


Andrographis Paniculata

[link to www.researchgate.net (secure)]


Conclusion: The present study suggests that neoandrographolide could be used as a potent inhibitor of MAO-B protein. However, it has to be validated using in-vivo and in-vitro studies to suggest the potency of neoandrographolide to inhibit the target protein, which could make neoandrographolide as an effective drug lead for the treatment of Alzhemier’s disease

and

[link to www.researchgate.net (secure)]

Antidepressant-like Activity of Andrographis paniculata in Type-2 Diabetic Rats


-----



tastes like hell

'King of bitters' it's called in Indian medicine

[link to en.wikipedia.org (secure)]



Anonymous Coward (OP)
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02/04/2019 10:45 AM
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
mescaline, MDMA, and bromo-dragonfly are phenethylamine derivatives :D

love drug is no joke :P
 Quoting: Anonymous Coward 70663772


[link to psychedelicreview.com (secure)]

Psychedelic Science Review


Phenylethylamine: An Overlooked Active Compound in “Magic” Mushrooms

Magic mushrooms have multiple active components including phenethylamine. These molecules are almost never acknowledged and are probably involved the pharmacology of magic mushrooms.
Anonymous Coward
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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
Looks like the winner is Licorice (for availability!):

[link to www.ncbi.nlm.nih.gov (secure)]


L2 Licorice Root Glycyrrhiza glabra IC50 <.07 mg/ml





[link to www.ncbi.nlm.nih.gov (secure)]

Source of direct phenylethylamine

Traditional Korean fermented soybean paste 82.03 mg/kg

Cheeses 9 to 40 mg/kg

Chocolate only: 2.67 mg/kg


Semi-rippened (cheese) 25.75 mg/kg Latorre-Moratalla et al. [76]

cheese unknown : "all Lactobacillus curvatus strains and 70% of Lactobacillus brevis strains had the capacity to produce tyramine and beta-phenylethylamine"


full list:

[link to www.ncbi.nlm.nih.gov (secure)]
Ladedah

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05/02/2019 08:28 PM

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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
Or maybe just drink a bunch of aspartame?


"THE BOTTOM LINE
1. Aspartame is metabolized to phenylalanine.

2. Phenylalanine is metabolized to phenylethylamine inducing competitive inhibition of 4.1.1.28 leading to decreased synthesis of serotonin, dopamine, and histamine.

3. Increases in phenylethylamine leads to excretion and associated depletion of serotonin and dopamine (catecholamine depletion).

4. As always, with depletion of catecholamines epinephrine (adrenaline) synthesis is the first to suffer dysfunction and suffers the most. Epinephrine and histamine share an agonist-antagonist interaction. With both histamine and epinephrine synthesis being compromised the problems grow."
[link to weeksmd.com]
As you think.
Ladedah

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05/02/2019 08:33 PM

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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
Palmitoylethanolamide is also known as PEA

It appears to be much safer, with more benefits. Be sure you know which PEA is which if you experiment with these supplements.

Palmitoylethanolamide
[link to selfhacked.com (secure)]
As you think.
wayQwyrd

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02/14/2021 10:54 AM

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Re: PEA - Phenethylamine - The Love Drug! Keep The Love Buzz
Been a while since i saved this thread.
If the OP is still around what does he\she think of Pure Hemp
Powder.?
I have been taking it for weight gain after losing 5 stone in 3 months due to Early (2019) Covid infection.
Whatever that shit was it damn nearly killed me. 13 weeks i had that fucking shit go through me.
Took me from 17.5 stone to 12.5 stone in 12 weaks.

Back up to 14.3 stone now but still listless and to be honest no mo-jo for months and months.

Would and increase of PEA affect or be affected by the Hemp powder ?

Will check back now and again to see if anyone reads this old thread.hf





GLP