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CoViD-19 Appears to Affect Smokers Less

 
Major Doom

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02/21/2020 05:02 PM

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Re: CoViD-19 Appears to Affect Smokers Less
You may also find this of interest.
It appears that smoking/nicotine inhibits the SARS-CoV-2 (Wuhan Kung Flu).

Chronic nicotine inhalation increases susceptibility to cardiovascular and pulmonary
diseases through inhibition of local compensatory mechanisms


Our pilot data suggest that cigarette smoke or nicotine inhalation inhibits the expression
of ACE2/AT2R in multiple organs including the brain, heart and lungs, thus disrupting the
balance within the RAS.


[link to grantome.com]
DOOM is what you make of it.
Anonymous Coward
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02/21/2020 05:03 PM
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Re: CoViD-19 Appears to Affect Smokers Less
Good timing on my behalf, i just started smoking few months ago. I roll my own cigars with natural Turkish tobacco though, won't even get close to commercial cigarettes. Not only they taste like crap and burn your throat but also they won't give you any buzz like natural tobacco does. I have been smoking approximately 3 cigars per day since i started, i can abstain at any time for any duration and dont get any withdrawal symptoms.
muddogg

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02/21/2020 05:04 PM

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Re: CoViD-19 Appears to Affect Smokers Less
Well.... I'm an O-, female, smoker..... And I drink Dos XX's.... I should be good! 🤣😂
Revbo™  (OP)
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02/21/2020 05:07 PM

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Re: CoViD-19 Appears to Affect Smokers Less
You may also find this of interest.
It appears that smoking/nicotine inhibits the SARS-CoV-2 (Wuhan Kung Flu).

Chronic nicotine inhalation increases susceptibility to cardiovascular and pulmonary
diseases through inhibition of local compensatory mechanisms


Our pilot data suggest that cigarette smoke or nicotine inhalation inhibits the expression
of ACE2/AT2R in multiple organs including the brain, heart and lungs, thus disrupting the
balance within the RAS.


[link to grantome.com]
 Quoting: Major Doom


So, basically, you'll die of emphysema when you're 85, but you'll survive Kung Flu.

Deal.
"Everyone has a plan until they get punched in the mouth." -Mike Tyson
fiora.ni

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02/21/2020 05:08 PM

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Re: CoViD-19 Appears to Affect Smokers Less
I've read, for years, that smokers did better with Spanish Flu because it suppressed the cytokine storm response, so I'm predisposed to think there's something there, but I would definitely like to see a much larger study done.
 Quoting: Revbo™


I never heard that about Spanish flu.

Although it make sense for reducing inflammation (may be acute inflammation) - there are some exercises to help with stuffy nose that involve doing squats while holding your breath.
Leaver

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02/21/2020 05:15 PM
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Re: CoViD-19 Appears to Affect Smokers Less
One of the best assemblies of info on smoking,pro ad anti, is on asite I can't link to. something like signals of the ages.
Major Doom

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02/21/2020 05:15 PM

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Re: CoViD-19 Appears to Affect Smokers Less
You may also find this of interest.
It appears that smoking/nicotine inhibits the SARS-CoV-2 (Wuhan Kung Flu).

Chronic nicotine inhalation increases susceptibility to cardiovascular and pulmonary
diseases through inhibition of local compensatory mechanisms


Our pilot data suggest that cigarette smoke or nicotine inhalation inhibits the expression
of ACE2/AT2R in multiple organs including the brain, heart and lungs, thus disrupting the
balance within the RAS.


[link to grantome.com]
 Quoting: Major Doom


So, basically, you'll die of emphysema when you're 85, but you'll survive Kung Flu.

Deal.
 Quoting: Revbo™


I suppose I would have a head start on it considering I already have COPD/Emphysema and just got out of the hospital from pneumonia due to inactivity and lessened exercise, as well as being a smoker/vaper. I tend to get lazy in the wintertime and not get out as often as I do when the weather is fair.
DOOM is what you make of it.
Revbo™  (OP)
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02/21/2020 05:22 PM

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Re: CoViD-19 Appears to Affect Smokers Less
I've read, for years, that smokers did better with Spanish Flu because it suppressed the cytokine storm response, so I'm predisposed to think there's something there, but I would definitely like to see a much larger study done.
 Quoting: Revbo™


I never heard that about Spanish flu.

Although it make sense for reducing inflammation (may be acute inflammation) - there are some exercises to help with stuffy nose that involve doing squats while holding your breath.
 Quoting: fiora.ni


This doesn't directly address smokers and the Spanish Flu although it makes the point. For some reason, I can't find a quick link to that although I've been reading about it for years and have been planning on using nicotine to suppress the cytokine storm response if I get CoViD. Even though this piece is talking more generally, the Spanish Flu and nicotine's effect on cytokine storm is mostly what I was looking for.

[link to www.ncbi.nlm.nih.gov (secure)]

For example, the H1N1 strain that caused the 1918 pandemic has been shown to induce higher levels of proinflammatory immune cells and cytokines in the lungs than seasonal influenza viruses. This contributes to its high virulence and may account for the unusually high mortality rate seen in otherwise healthy young adults during the outbreak

Nicotine is a nonselective agonist of the α7Ach receptor and is able to suppress the production of proinflammatory cytokines by mimicking the binding of acetylcholine. It has been demonstrated that nicotine can selectively reduce the inflammatory response in a number of infection scenarios, including Legionella pneumophila (54) and Chlamydia pneumoniae (55) infection; however, it is highly unlikely that nicotine will ever be used clinically due to its toxicity, addictive nature, and lack of specificity.

Last Edited by Revbo™ on 02/21/2020 05:27 PM
"Everyone has a plan until they get punched in the mouth." -Mike Tyson
Anonymous Coward
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02/21/2020 05:24 PM
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Re: CoViD-19 Appears to Affect Smokers Less
Well Fuck.. Now they will use this to drive up the price even more on a pack of butts.
 Quoting: Nefarious Libertine


I don't know how anyone can afford to smoke anymore. One pack of smokes cost as much as an entire carton used to. When I started smoking in high school, a pack of smokes was 25 cents and a carton was $3.
 Quoting: Catnip


Pipe tobacco, it's 1/10th the price because 9/10 of the price of the average pack of cigs is from taxes to pay for gov't gibs.
Revbo™  (OP)
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02/21/2020 05:25 PM

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Re: CoViD-19 Appears to Affect Smokers Less
You may also find this of interest.
It appears that smoking/nicotine inhibits the SARS-CoV-2 (Wuhan Kung Flu).

Chronic nicotine inhalation increases susceptibility to cardiovascular and pulmonary
diseases through inhibition of local compensatory mechanisms


Our pilot data suggest that cigarette smoke or nicotine inhalation inhibits the expression
of ACE2/AT2R in multiple organs including the brain, heart and lungs, thus disrupting the
balance within the RAS.


[link to grantome.com]
 Quoting: Major Doom


So, basically, you'll die of emphysema when you're 85, but you'll survive Kung Flu.

Deal.
 Quoting: Revbo™


I suppose I would have a head start on it considering I already have COPD/Emphysema and just got out of the hospital from pneumonia due to inactivity and lessened exercise, as well as being a smoker/vaper. I tend to get lazy in the wintertime and not get out as often as I do when the weather is fair.
 Quoting: Major Doom


Well, that sucks, but it sounds like you may have a better chance of making it through this pandemic than a 25-year-old marathon runner.
"Everyone has a plan until they get punched in the mouth." -Mike Tyson
Major Doom

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02/21/2020 05:38 PM

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Re: CoViD-19 Appears to Affect Smokers Less
There may be something to this nicotine/nCoV-19 relation...
Here is another, very in-depth report in this topic:

Alternative Roles of STAT3 and MAPK Signaling Pathways in the MMPs Activation and Progression of Lung Injury Induced by Cigarette Smoke Exposure in ACE2 Knockout Mice

Abstract (in part):
Inflammation-mediated abnormalities in the renin-angiotensin system (RAS) and expression of matrix metalloproteinases (MMPs) are implicated in the pathogenesis of lung injury. Angiotensin converting enzyme II (ACE2), an angiotensin converting enzyme (ACE) homologue that displays antagonist effects on ACE/angiotensin II (Ang II) axis, could also play a protective role against lung diseases. However, the relationship between ACE2 and MMPs activation in lung injury is still largely unclear. The purpose of this study is to investigate whether MMPs activity could be affected by ACE2 and which ACE2 derived signaling pathways could be also involved via using a mouse model with lung injury induced by cigarette smoke (CS) exposure for 1 to 3 weeks.

[link to www.ncbi.nlm.nih.gov (secure)]

-------
EDIT:
Possible Inhibitors of ACE2, the Receptor of 2019-nCoV
Abstract:
Most recently, an outbreak of severe pneumonia caused by the infection of 2019-nCoV, a novel coronavirus first identified in Wuhan, China, imposes serious threats to public health. Many important aspects about 2019-nCoV remain largely unknown, among which, the limitation of antiviral therapies represents one of the most critical problems. More recently, it was confirmed that human ACE2 is the receptor for the entry of 2019-nCoV into lower respiratory tract epithelial cells. Give this observation, it is thus expected that the virus could be inhibited if we decrease the expression of ACE2. Here by screening two databases, Connectivity Map (CMap) and our JeaMoon Map (JMap), we identified a number of candidate agents that decrease ACE2 expression. CMap analysis identified 5 compounds, among which, Azathioprine is a possible therapeutic strategy for anti-2019-nCoV. Moreover, JMap analysis revealed a number of comounds, biologics, and traditional Chinese medicine, among which, Andrographis, Urtica, Sambucus, Astragalus, valproic acid, butyrate, and epoxomicin represent the most significant and possible strategies for anti-2019-nCoV therapies. This study provides a number of clues and possible therapeutic strategies for 2019-nCoV prevention and treatment.

[link to www.preprints.org (secure)]

-------

Others that are related:

Angiotensin-converting enzyme-2 overexpression attenuates inflammation in rat model of chronic obstructive pulmonary disease
[link to www.tandfonline.com (secure)]

Bulk and single-cell transcriptomics identify tobacco-use disparity in lung gene expression of ACE2, the receptor of 2019-nCov
[link to www.medrxiv.org (secure)]

Tobacco-Use Disparity in Gene Expression of ACE2, the Receptor of 2019-nCov (not peer reviewed)
[link to www.preprints.org (secure)]

Nicotine and the renin-angiotensin system
[link to journals.physiology.org (secure)]

Losartan attenuates chronic cigarette smoke exposure-induced pulmonary arterial hypertension in rats: Possible involvement of angiotensin-converting enzyme-2
[link to www.sciencedirect.com (secure)]

Last Edited by Major Doom on 02/21/2020 05:40 PM
DOOM is what you make of it.
Revbo™  (OP)
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02/21/2020 05:40 PM

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Re: CoViD-19 Appears to Affect Smokers Less
Thanks, MD. I did some GLP digging and found this post from the Swine Flu days.

"This ability of nicotine to attenuate an inflammatory response may also be the cause of reduced mortality of chronically nicotine-treated mice from acute influenza A pneumonitis."
[link to www.sciencedirect.com]

"Moreover, nicotine appears to moderate the inflammation associated with turpentine-induced sterile abscess and influenza infection. These anti-inflammatory properties of nicotine may account for longer survival of nicotine-treated than control mice lethally infected with influenza virus."
[link to www.ncbi.nlm.nih.gov]
 Quoting: Anonymous Coward 662540


Last Edited by Revbo™ on 02/21/2020 05:44 PM
"Everyone has a plan until they get punched in the mouth." -Mike Tyson
Major Doom

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02/21/2020 05:42 PM

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Re: CoViD-19 Appears to Affect Smokers Less
I edited my post above with something very recent:
Possible Inhibitors of ACE2, the Receptor of 2019-nCoV

very interesting thread you created.

already got 5 stars from me :)
DOOM is what you make of it.
Revbo™  (OP)
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02/21/2020 05:42 PM

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Re: CoViD-19 Appears to Affect Smokers Less
Lots of good info in this thread from 2009.

Thread: Swine Flu? Smoke em if you got it; Nicotine can stop Cytokine Storm
"Everyone has a plan until they get punched in the mouth." -Mike Tyson
Anonymous Coward
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02/21/2020 05:52 PM
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Re: CoViD-19 Appears to Affect Smokers Less
Well Fuck.. Now they will use this to drive up the price even more on a pack of butts.
 Quoting: Nefarious Libertine


I don't know how anyone can afford to smoke anymore. One pack of smokes cost as much as an entire carton used to. When I started smoking in high school, a pack of smokes was 25 cents and a carton was $3.
 Quoting: Catnip


Roll your own
Major Doom

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02/21/2020 05:56 PM

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Re: CoViD-19 Appears to Affect Smokers Less
 Quoting: Revbo™


I've been a regular smoker for 41 years and roll my own. Sometimes I may smoke tobacco from my corncob pipe. Instead of dumping ashtrays, I take all the cigarette butts and put them in a can. If I run low on tobacco, I pull the butts apart and either roll a cigarette or use my pipe. Also, I use the cigarette butts for the insecticide properties for plants/crops (soaked in water to leech the alkaloids, diluted with water and a squirt of dish soap, placed in a hand-pumped sprayer). Nicotine is no stranger for this hillbilly!

Last Edited by Major Doom on 02/21/2020 05:58 PM
DOOM is what you make of it.
Anonymous Coward
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02/22/2020 04:26 AM
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This is pin worthy!
hf
Anonymous Coward
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02/22/2020 07:44 AM
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5 stars.
mondali2

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02/22/2020 08:09 AM
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Re: CoViD-19 Appears to Affect Smokers Less
Nicotine stops a cytokine storm.

The nicotine molecules bind to the cytokine receptors and stop the cascading reaction.

Known for a long time but suppressed - it's why you see the guys smoking pipes in those woodcuts depicting them burying bodies from the great plague.

[link to www.ncbi.nlm.nih.gov (secure)]
 Quoting: Anonymous Coward 77547432


Yes, mmost of those dying are dying as a result of the cytokine storm. Smoking limits the cytokine storm.
mondali2
the one
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02/22/2020 08:19 AM
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Re: CoViD-19 Appears to Affect Smokers Less
I smoke two packs of smokes a day but make own with natural pipe tobacco I have no cough no luggies like did when i smoked name brands.
Nagabonar666

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02/22/2020 08:31 AM
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Re: CoViD-19 Appears to Affect Smokers Less
This is the first study I've seen on a group of Wuhan patients and the results are dumbfounding. In addition to the data presented below, the average age in the study was 57, so it appears that Kung Flu prefers healthy, developed lungs. I've only read a few pages of this, so everybody dig in and see if you come to the same conclusions.

[link to onlinelibrary.wiley.com (secure)]

smokers are not affected: Asthma or other allergic diseases was not reported by any of the patients. Chronic obstructive pulmonary disease (COPD, 1.4%) and current smokers (1.4%) were rare.
 Quoting: Anonymous Coward 71177194

 Quoting: Revbo™


Great thread, thanks for pointing this out!

Tobacco is actually of the nightshade family (same like tomato or potato) and Nicotine is an Alkaloid (toxic defense compound produced by the plant against insects). Many Alcaloids have medicinal properties (but many also bad side effects, or both medicinal and side effects)
[link to en.m.wikipedia.org (secure)]

They did some research on mice, exposed it to nicotine smoke for 21 days and other mice to normal air. They then injected Avian Flu H1N1 into the mice. Guess what? The mortality of nicotine exposed mice was significantly lower, also suppressed Cytokine storm:
[link to www.ncbi.nlm.nih.gov (secure)]

There are also several other studies available in relation to Nicotine and SARS


Permission to include this info with link to this thread, and tobacco on my list of herbs please hf:

Thread: HERB SUMMARY vs COVID-19: Cinchona Bark > Quinine/ Chloroquine, Turmeric, Andrographis, Kratom, Thieves Oil, Lomatium, Propolis, Mullein & MORE

Last Edited by Nagabonar666 on 02/22/2020 08:53 AM
Revbo™  (OP)
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02/22/2020 09:00 AM

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Re: CoViD-19 Appears to Affect Smokers Less
This is the first study I've seen on a group of Wuhan patients and the results are dumbfounding. In addition to the data presented below, the average age in the study was 57, so it appears that Kung Flu prefers healthy, developed lungs. I've only read a few pages of this, so everybody dig in and see if you come to the same conclusions.

[link to onlinelibrary.wiley.com (secure)]

smokers are not affected: Asthma or other allergic diseases was not reported by any of the patients. Chronic obstructive pulmonary disease (COPD, 1.4%) and current smokers (1.4%) were rare.
 Quoting: Anonymous Coward 71177194

 Quoting: Revbo™


Great thread, thanks for pointing this out!

Tobacco is actually of the nightshade family (same like tomato or potato) and Nicotine is an Alkaloid (toxic defense compound produced by the plant against insects). Many Alcaloids have medicinal properties (but many also bad side effects, or both medicinal and side effects)
[link to en.m.wikipedia.org (secure)]

They did some research on mice, exposed it to nicotine smoke for 21 days and other mice to normal air. They then injected Avian Flu H1N1 into the mice. Guess what? The mortality of nicotine exposed mice was significantly lower, also suppressed Cytokine storm:
[link to www.ncbi.nlm.nih.gov (secure)]

There are also several other studies available in relation to Nicotine and SARS


Permission to include this info with link to this thread, and tobacco on my list of herbs please hf:

Thread: HERB SUMMARY vs COVID-19: Cinchona Bark > Quinine/ Chloroquine, Turmeric, Andrographis, Kratom, Thieves Oil, Lomatium, Propolis, Mullein & MORE
 Quoting: Nagabonar666


Granted. cheers
"Everyone has a plan until they get punched in the mouth." -Mike Tyson
fiora.ni

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02/22/2020 11:55 AM

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Re: CoViD-19 Appears to Affect Smokers Less
It is not my find, but I figured I copy it from main thread anyway

[link to www.medrxiv.org (secure)]

Sample size: 1099


Never smokers(total) 927/1085 (85.4)
Non-severe: 793/913 (86.9)
Severe: 134/172 (77.9)

Ex-smokers(total): 21/1085 (1.9)
Non-severe: 12/913 (1.3)
Severe: 9/172 (5.2)

Current smokers(total) 137/1085 (12.6)
Non-severe: 108/913 (11.8)
Severe: 29/172 (16.9)

Current smokers are still lower then in total population, but started catching up.
Nagabonar666

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02/22/2020 12:43 PM
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Re: CoViD-19 Appears to Affect Smokers Less
This is the first study I've seen on a group of Wuhan patients and the results are dumbfounding. In addition to the data presented below, the average age in the study was 57, so it appears that Kung Flu prefers healthy, developed lungs. I've only read a few pages of this, so everybody dig in and see if you come to the same conclusions.

[link to onlinelibrary.wiley.com (secure)]

smokers are not affected: Asthma or other allergic diseases was not reported by any of the patients. Chronic obstructive pulmonary disease (COPD, 1.4%) and current smokers (1.4%) were rare.
 Quoting: Anonymous Coward 71177194

 Quoting: Revbo™


Great thread, thanks for pointing this out!

Tobacco is actually of the nightshade family (same like tomato or potato) and Nicotine is an Alkaloid (toxic defense compound produced by the plant against insects). Many Alcaloids have medicinal properties (but many also bad side effects, or both medicinal and side effects)
[link to en.m.wikipedia.org (secure)]

They did some research on mice, exposed it to nicotine smoke for 21 days and other mice to normal air. They then injected Avian Flu H1N1 into the mice. Guess what? The mortality of nicotine exposed mice was significantly lower, also suppressed Cytokine storm:
[link to www.ncbi.nlm.nih.gov (secure)]

There are also several other studies available in relation to Nicotine and SARS


Permission to include this info with link to this thread, and tobacco on my list of herbs please hf:

Thread: HERB SUMMARY vs COVID-19: Cinchona Bark > Quinine/ Chloroquine, Turmeric, Andrographis, Kratom, Thieves Oil, Lomatium, Propolis, Mullein & MORE
 Quoting: Nagabonar666


Granted. cheers
 Quoting: Revbo™


Cheers!


On wikipedia tobacco plant includes both nicotine and harmala alkaloids.

In ancient middle eastern medicine they used the Harmala herb (African Rue) as treatment for Parkinson tremors, high blood pressure and neurological disorders such as depression and psycatric / nervous conditions. [link to books.google.co.id (secure)] .Recent studies also suggest that Harmala also has antiviral properties against influenza A virus. [link to www.ncbi.nlm.nih.gov (secure)]

"Viral infections like the flu...can cause high blood pressure..raise odds for heart attack or stroke"
[link to www.webmd.com (secure)]

"researchers have found proof of a direct association between strain OC 43 of the human coronavirus (HCoV) and neurological disease"
[link to www.sciencedaily.com (secure)]

"the new coronavirus behaves more like influenza than SARS"
[link to www.pharmacist.com (secure)]

Now the fun part. Wikepdia only mentions that tobacco has nicotine and harmala ingredients. But actually tobacco has 5 more minor alkaloids (less then 5% of total alkaloids): anabasine, nornicotine, anatabine, cotinine and myosmine
[link to academic.oup.com (secure)]

Short summary of Tobacco Alkaloids:

1. Nicotine: anti-inflammatory for immune and nervous system, suppresses cytokine production
[link to pdfs.semanticscholar.org (secure)]

2. Harmala:anti-viral (anti flu), anti-inflammatory, treats hypertension and neurological disorders

3. Anabasine:more toxic then nicotine, ancient egyptians used it as anti-septic, anti-inflammatory
[link to www.sciencedirect.com (secure)]

4. Nornicotine: similar applications to nicotine

5. Anatabine: anti-inflammatory and reduces pro-inflammatory production of cytokines also reduces neuro-inflammation
[link to www.researchgate.net (secure)]

6. Cotinene: main metabolite of nicotine, agent against psychiatric conditions and decreases fear
[link to www.ncbi.nlm.nih.gov (secure)]

7. Myosmine: no benefits found. Apparantly a carcinogen (cancer causing)

Last Edited by Nagabonar666 on 02/22/2020 07:51 PM
SARS-CoV-2
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02/22/2020 12:51 PM
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Re: CoViD-19 Appears to Affect Smokers Less
Please refer to it as SARS-CoV-2

It is SARS2
Thread: SARS-CoV-2 severe acute respiratory syndrome coronavirus 2

Thank you.
Weyoun

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02/22/2020 06:09 PM
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Please refer to it as SARS-CoV-2

It is SARS2
Thread: SARS-CoV-2 severe acute respiratory syndrome coronavirus 2

Thank you.
 Quoting: SARS-CoV-2 78481048


No. It's chynavirus.
silverfoxdude

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02/26/2020 05:43 PM

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Re: CoViD-19 Appears to Affect Smokers Less
Well Fuck.. Now they will use this to drive up the price even more on a pack of butts.
 Quoting: Nefarious Libertine


I don't know how anyone can afford to smoke anymore. One pack of smokes cost as much as an entire carton used to. When I started smoking in high school, a pack of smokes was 25 cents and a carton was $3.
 Quoting: Catnip

silverfoxdude
silverfoxdude

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02/26/2020 05:44 PM

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Re: CoViD-19 Appears to Affect Smokers Less
Well Fuck.. Now they will use this to drive up the price even more on a pack of butts.
 Quoting: Nefarious Libertine


I don't know how anyone can afford to smoke anymore. One pack of smokes cost as much as an entire carton used to. When I started smoking in high school, a pack of smokes was 25 cents and a carton was $3.
 Quoting: Catnip

 Quoting: silverfoxdude

in the uk its !3 dollars a pack
silverfoxdude
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Thread: Anyone made plans for needing oxygen for home treatment of CV?
Anonymous Coward
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02/26/2020 06:06 PM
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Re: CoViD-19 Appears to Affect Smokers Less
I knew it, everything must have a good side, even smoking. My lungs are virus-protected by a nicotine layer which kills Corona, haha.

So cool. We smokers were victimized over and over ... and now we will rule the world as only survivors.





GLP