Godlike Productions - Discussion Forum
Users Online Now: 1,504 (Who's On?)Visitors Today: 315,910
Pageviews Today: 515,859Threads Today: 172Posts Today: 3,002
07:19 AM


Back to Forum
Back to Forum
Back to Thread
Back to Thread
REPORT COPYRIGHT VIOLATION IN REPLY
Message Subject Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected *notes to self
Poster Handle Anonymous Coward
Post Content
[link to www.preprints.org (secure)]

Revealing the Potency of Citrus and Galangal Constituents
to Halt SARS-CoV-2 Infection



Rohmad Yudi Utomo1,2, Muthi’ Ikawati1,3, Edy Meiyanto1,3,*
1Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada (UGM),
Sekip Utara, Yogyakarta 55281, Indonesia
2Medicinal Chemistry Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy,
UGM, Sekip Utara, Yogyakarta 55281, Indonesia
3Macromolecular Engineering Laboratory, Department of Pharmaceutical Chemistry, Faculty of
Pharmacy UGM, Sekip Utara, Yogyakarta 55281, Indonesia
*


ORCID:
Edy Meiyanto: 0000-0002-0886-6322
Rohmad Yudi Utomo: 0000-0003-4803-9417
Muthi’ Ikawati: 0000-0002-5968-0130

Abstract

COVID-19 pandemic is a serious problem in the world today. The SARS-CoV-2 virus that causes
COVID-19 has important proteins used for its infection and development, namely the protease and
spike glycoprotein. The RBD (Receptor Binding Domain) of spike glycoprotein (RBD-S) can bind to the
ACE2 (Angiotensin Converting Enzyme-2) receptor at the protease domain (PD) (PD-ACE2) of the host
cell, thereby leading to a viral infection. This study aims to reveal the potential of compounds contained
in Curcuma sp., Citrus sp., Alpinia galanga, and Caesalpinia sappan as anti SARS-CoV-2 through its
binding to 3 protein receptors. The study was conducted by molecular docking using the MOE 2010
program (licensed from Faculty of Pharmacy UGM, Indonesia). The selected protein targets are RBDS (PDB ID:6LXT), PD-ACE2 (PDB ID: 6VW1), and SARS-CoV-2 protease (PDB ID:6LU7). The affinities
of bonds formed is represented as a docking score. The results show that hesperidin, one of the
compounds in Citrus sp., has the lowest docking score for all three protein receptors representing the
highest affinity to bind the receptors. Moreover, all of the citrus flavonoids possess good affinity to the
respected receptors as well as curcumin, brazilin, and galangin, indicating that those compounds
perform inhibitory potential for the viral infection and replication. In general, the results of this study
indicate that Citrus sp. exhibit the best potential as an inhibitor to the development of the SARS-CoV2, followed by galangal, sappan wood, and Curcuma sp. that can be consumed in daily life as
prophylaxis of COVID-19
.
Keywords: SARS-CoV-2; Citrus sp., Galangal, Curcuma sp., Sappan wood


All these data represent the potential inhibitory effect of Citrus sp., Curcuma sp., C. sappan, and A.
galanga on SARS-CoV-2 infection and development that may be addressed for treatment and
prevention of COVID-19. Based on the docking scores of the constituents, Citrus sp. showed the best
potency, followed by A. galanga, sappan wood, and Curcuma sp. Noted for Curcuma sp. and sappan
wood which are the main ingredients of most Indonesian traditional medicine “jamu” formulas, it is
commonly believed to contribute in maintaining health condition due to its antioxidant activities of their
constituents, such as curcumin in curcuma rhizome and brazilin in sappan wood (Meiyanto & Larasati,
2019). People usually consume these herbs in various drinking herbal formulas. This finding supports
the use of those medicinal plants for preventive or prophylaxis treatment against beta corona virus
infection, including SARS-CoV-2. The same antiviral potency also performed by galangal which mainly
contain galangin. Galangal has been used as spices for several food and exhibit pharmacological
benefit as anti-ageing (Ahlina et al., 2020). This finding gives us to the additional benefit of this herb for
antiviral.
 
Please verify you're human:




Reason for copyright violation:







GLP