Breaking - VERY IMPORTANT - Taking anti-inflammatory drugs (Ibuprofen, Cortisone, etc) could be an aggravating factor of the infection

So how to bring down a fever when they don’t recommend using Tylenol and a fever together?

In Germany they say it's fake news with ibuprofen. Lol

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This. Person. Gets. It.

Another. Smart. One. Gets. It.

Rise up People.

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

[link to www.sciencedirect.com (secure)]


Table 1. Potential PLpro inhibitors from ZINC drug database (compounds in the table are ranked according to their docking scores).

No. Drug name Structure Pharmacological function
1 Ribavirin Image 2 Anti-virus
2 Valganciclovir Image 3 Anti-virus
3 β-Thymidine Image 4 Anti-virus
4 Aspartame Image 5 Non-carbohydrate sweetener
5 Oxprenolol Image 6 Anti-hypertensive, anti-angina,
anti-arrhythmic effects
6 Doxycycline Image 7 Anti-bacterial effect
7 Acetophenazine Image 8 Anti-psychotic effect
8 Iopromide Image 9 Low osmolar, non-ionic contrast agent
9 Riboflavin Image 10 Treatment of vitamin B2 deficiency
10 Reproterol Image 11 Treatment of bronchial asthma
11 2,2′-Cyclocytidine Image 12 Anti-tumor
12 Chloramphenicol Image 13 Anti-bacterial effect
13 Chlorphenesin carbamate Image 14 Muscle relaxant effect
14 Levodropropizine Image 15 Anti-tussive effect
15 Cefamandole Image 16 Anti-bacterial effect
16 Floxuridine Image 17 Anti-tumor
17 Tigecycline Image 18 Anti-bacterial
18 Pemetrexed Image 19 Anti-tumor
19 L(+)-Ascorbic acid Image 20 Anti-scorbutic
20 Glutathione Image 21 Treatment of hepatic disease
21 Hesperetin Image 22 Anti-oxidation, anti-virus,
anti-bacteria
22 Ademetionine Image 23 Cholagogue
23 Masoprocol Image 24 Treatment of actinic keratosis
24 Isotretinoin Image 25 Anti-tumor
25 Dantrolene Image 26 Muscle relaxant
26 Sulfasalazine Image 27 Anti-bacterial effect
27 Silybin Image 28 Hepatoprotective effect
28 Nicardipine Image 29 Anti-hypertensive effect
29 Sildenafil Image 30 Treatment of erectile dysfunction


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Table 2. Potential PLpro inhibitors from in-house natural product database.

No. Compound name Structure Pharmacological function Source
1 Platycodin D Image 31 Anti-tumor, anti-inflammatory effect Platycodon grandiflorus
2 Chrysin Image 32 Anti-virus, anti-inflammatory effect Scutellaria baicalensis
3 Neohesperidin Image 33 Anti-tumor, anti-allergic effect Citrus aurantium L.
4 Baicalin Image 34 Anti-tumor, anti-inflammatory, anti-bacterial, anti-virus effect Scutellaria baicalensis
5 Sugetriol-3,9-diacetate Image 35 Anti-HBV,
Anti-HSV-1 Cyperus rotundus
6 (–)-Epigallocatechin gallate Image 36 Anti-oxidation, anti-tumor, treatment of depression Camellia sinensis
7 Phaitanthrin D Image 37 Anti-virus Isatis indigotica Fort.
8 2-(3,4-Dihydroxyphenyl)-2-[[2-(3,4-dihydroxyphenyl)-3,4-dih​ydro-5,7-dihydroxy-2H-1-benzopyran-3-yl]oxy]-3,4-dihydro-2H-1​-benzopyran-3,4,5,7-tetrol Image 38 Anti-oxidant, anti-inflammatory, anti-tumor Vitis vinifera
9 2,2-Di(3-indolyl)-3-indolone Image 39 Anti-virus Isatis indigotica Fort.
10 (S)-(1S,2R,4aS,5R,8aS)-1-Formamido-1,4a-dimethyl-6-methyle​ne-5-((E)-2-(2-oxo-2,5-dihydrofuran-3-yl)ethenyl)decahydronap​hthalen-2-yl-2-amino-3-phenylpropanoate Image 40 Anti-virus, anti-inflammatory effect Andrographolide derivatives
11 Piceatannol Image 41 Anti-tumor, anti-virus effect Vitis vinifera
12 Rosmarinic acid Image 42 Anti-virus,
Anti-oxidant Salvia verticillata L.
13 Magnolol Image 43 Anti-tumor,
Anti-microbial effect Magnolia officinalis





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We have identified a number of compounds that might have anti-viral activity from the approved drugs library, such as anti-virus drugs (ribavirin, valganciclovir and thymidine), anti-bacterial drugs (cefpiramide, sulfasalazine, phenethicillin, lymecycline, demeclocycline, doxycycline, oxytetracycline and tigecycline), anti-asthmatic drugs (montelukast, fenoterol and reproterol), and hepatoprotective drug silybin. The original pharmacological actions of these drugs could be helpful for the therapy of viral infection pneumonia. The natural products, such as flavanoids like neohesperidin, hesperidin, baicalin, kaempferol 3-O-rutinoside and rutin from different sources, andrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide from Andrographis paniculata, and a series of xanthones from the plants of Swertia genus, with anti-virus, anti-bacteria and anti-inflammation activity could effectively interact with these targets of SARS-CoV-2. Therefore, the herbal medicines containing these compounds as major components might be meaningful for the treatment of SARS-CoV-2 infections.

For ACE2 target, although several compounds could bind with ACE2 through virtual screening in our studies, no compound was found to bind with the contact surface of ACE2–Spike complex, suggesting that these compounds are only the inhibitors of ACE2 enzyme activities, rather than inhibitors of ACE2 driven virus infections. Just like what described in recently published research53, most of selected compounds are also unable to bind with the contact surface of ACE2–Spike complex. Actually, these potential ACE2 inhibitors may not be suitable to use as drugs for treating SARS-CoV-2 infection because the poor prognosis would be induced by the inhibition of ACE2 enzyme activities, for ACE2 was considered as a protective factor of lung injury54.

For those targets which are difficult to find direct inhibitors, or non-druggable targets, just like Nsp1, Nsp3b, Nsp3c, and E-channel, etc., currently popular PROTAC technology may be a good strategy to degrade these proteins and then inhibit the virus. The potential binding compounds found in this study for these targets might be a good start point.

For Spike protein, we found only one compound, natural hesperidin was targeting the binding between Spike RBD and human ACE2. However, not like the ACE2 binding compounds, non-interface binding compound may still meaningful applications, considering that the fusion of CoVs membrane with host cell membrane need the big conformational change of remained Spike part after RBD removal55. Any small molecule bound to Spike at this time may interfere the re-folding of Spike therefore inhibits the viral infection process. Furthermore, small molecule that can target any part of Spike protein may be a good start point to design PROTAC based therapy.

Also, we dock existing anti-viral drugs with our targets, analyze the possible targets of each anti-viral drug horizontally, and analyze the drugs that may interact with 21 targets vertically. We analyzed 21 targets based on the docking results and found that Nsp3b, Nsp3c, Nsp7_Nsp8 complex, Nsp14, Nsp15, PLpro, 3CLpro, RdRp, helicase, E-channel, Spike and ACE2 are more likely to be therapeutic targets of anti-viral drugs. The three targets Nsp3b, Nsp3c, and E-channel are screened more anti-viral drugs. This may be due to the model problem because of flexible small protein (Nsp3b and Nsp3c) or partial model (E-channel). Whether the screened anti-viral drugs really work on these targets needs further verification. We also do not recommend the application of new coronavirus pneumonia to compounds for which no target has been predicted.

The triphosphate nucleotide product of remdesivir, remdesivir-TP, competes with RdRp for substrate ATP, so it can interfere with viral RNA synthesis. Our docking results show that remdesivir-TP binds to SARS-CoV-2 RdRp, with a score of –112.8, and the docking results are consistent with its original anti-viral mechanism, so we think remdesivir may be good in treating SARS-CoV-2 pneumonia. In addition, remdesivir also predicted to bind with the human TMPRSS2, a protein facilitating the virus infection, this is a new discovery and provides ideas for subsequent research.

Chloroquine phosphate has shown better anti-SARS-CoV-2 effects in recent studies, but this drug has no clear target of action. In our docking results, chloroquine phosphate is predicted to possibly combine with Nsp3b and E-channel. But we need to do further experiments to verify this conclusion.

In response to the recently reported anti-AIDS drugs lopinavir and ritonavir tablets, which have a poor effect on the treatment of novel coronavirus pneumonia and have toxic side effects, we analyzed it in conjunction with the docking results. The molecular docking results show that ritonavir’s possible target is Nsp3c or E-channel. Lopinavir’s possible target is Nsp3b, Nsp3c, helicase, NRBD or E-channel. Some of these targets (such as Nsp3b, Nsp3c, E-channel) may be false positives due to the model inaccuracy for small flexible protein or partial model. For both lopinavir and ritonavir, we did not observe possible binding to major targets like 3CLpro, PLpro, RdRp, and so on. This docking result implies lopinavir and ritonavir tablets may not be suitable for treatment of SARS-CoV-2 infections.

The results of the entire article are based on computer virtual screening. We have not conduct further in vivo and in vitro anti-viral experiments yet, because we want to share our results with scientists in anti-SARS-CoV-2 research as soon as possible. Our subsequent research will try to solve the three-dimensional structures of all 24 proteins of SARS-CoV-2 and their drug complexes, providing more target information for drug intervention and long-term drug design, perform in vivo and in vitro evaluations for candidate drugs obtained in this study, and prepare for clinical trial applications.






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citrus and peel, OJ by the bottle
Apartame! - wtf!
Skullcap!
Andrographis herb
chloroquine anti-malarial as the big guns

What about TUMERIC!?!?!?!

Best stuff out there for arthritis
[/quote

I am wondering that too.

Does that also mean avoiding other anti inflammatory products such as turmeric, curcumin and oregano oil?

We were being told a few days ago that India possibly had so few cases as they ate a diet rich in turmeric etc?!!

Tylenol = paracetamol = acetaminophen

aspirin for fever nothing else

If you have a fever, just let it fever. Fevers are what the body uses to destroy viruses.

lol, um yeah das riight. 'cept for kids cause if you give em aspirin they can get fuckin brain damaga from Reyes Syndrome u nitwit

I wastaking ibuprofen 800mg for a bad wisdom tooth infection for weeks and still get a fever/migraine on and off. Got it pulled 3 days ago and still took some smaller ones for pain. That explains alot! Thanks for info

Eh, I'm still taking it.

Turmeric, curcumin (esp with black pepper), vitamin D, vitamin C, magnesium, zinc, copper, baking soda, red wine, sea salt (iodine).

All these things can help. Proper dosage and digestion is important.

Remember, food is medicine.

Cocaine is all natural like heroine that’s what I do.

I had that about 6 years ago, wisdom tooth infection. Got it pulled and felt better immediately. Self-medicated only with red wine and cannabis, did not take any of the prescribed painkillers. Was 100% better within 5 days.

The body is an amazing machine if treated right.

yeah, das riight!

except when they start seizing from high fever as brain cell death occurs!

how bout u get back to me with the maximal temp permitted before treatment with a fever reducer

or... based on your theory we just let that fever turn the brain into PATE!!

Never touched the shit and would never try. Always feared I would like it too much. Do you buy your cocaine certified organic? Are your needles USDA choice?

I think some things are best left for others, I don't know how you could go wrong with red wine and weed in moderation, there's no better medicine in the world.

idiot. If your fever gets that high that it's melting your brain, you need to be in a hospital and you've got a lot more wrong with you that something that can be treated with ibuprofen.

This post is confusing and lots of people chiming in making it worse.

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So take ACETAMINOPHEN but don't take IBUPROFEN

I guess it doesn't matter on the name brand just make sure the label says acetaminophen and not ibuprofen.

Correct?

ACETAMINOPHEN gives you asthma, and fucks your immune system

both bad. dont want asthma if COV19 is fucking your lungs already

[link to www.webmd.com (secure)]



take codeine
or
asprin
or
natural alternative

or ride it out

oh, so fucking sorry to offend you!

so you forgot to tell me that number and you forgot to mention how closely you were monitoring your loved one prior to them crossing the threshold of unacceptable temps!!

or worse yet, maybe the persons alone and passes out while the Pate formation ensues!! then what you gonna say. "Well sir they were still awake when i left them alone but i did recommend they not take fever reducer cause its 'natures waay'"

awwww your quite the expert!

M.O.R.A.N.

you will soon come to understand Yoda that there are a GREAT many thing your fucking clueless about.

Jesus uses turmeric every day. He started using it at 18, institutionally.

I meant instinctually

Pick your poison.

Acetaminophen: liver damage, lack of empathy to pain.

Ibuprofen: heart and kidney disease, leaky gut and internal bleeding.

Aspirin: internal bleeding, Reye's syndrome.

Last Edited by Monty Python on 03/14/2020 03:13 PM

Gospel and 30 of nearly 40 years in medicine. Foods exceed drugs....but the life attitude matters a lot.

Cocaine is only good for topical use. Heroin causes pneumonia. So your "bush dealer" thing would be to add a little bit of cocaine to your heroin for a lung propper upper. But really, a little medicine may help, but very much just contributes to being worse.
We used to do it a lot for the terminals....now i just dont even want to think about the ghoul bastar*s

To wit:
Brompton_cockt...
Brompton cocktail - Wikipedia
Made from morphine or diacetylmorphine (heroin), cocaine, highly-pure ethyl alcohol (some recipes specify gin), and sometimes with chlorpromazine (Thorazine) to counteract nausea, it was given to terminally-ill individuals (especially cancer patients) to relieve pain and promote sociability near death.
Wikipedia › wiki › Brompton_cockt...
Brompton cocktail - Wikipedia

But I have been making, mixing and applying drugs almost 40 years....i make stuff sound easy and people need to know what they can.
My nightmare is thinking about all these people that never did any of this and poisoning or hurting their loved one. That is my doctors prayer. I pray for the people that my life and heartbreaks will fall on and they don't even know kung fu. I've seen people caught in fearful decisions and luck was with most of them, that their courage hold up.
I always signed my medical articles "Best Wishes Always" back then and did on my covid letter for amha
May God be with you and whatever happens? Doctors walk until we drop and you can too.

Alieve is an anti-inflammatory. Is it ok to use?

Use MSM (methylsulfonylmethane) - it works much better for asthma,

I know this may sound too simplistic, but (from what I have observed) it works:

If you get a fever, drink A LOT of water.

In my experience, it works effectively to reduce body temperature at least a few degrees -- enough to get you away from the danger zone.

Last Edited by Elegant Walnut on 03/14/2020 04:29 PM