Rushed Vaccine could lead to “immune enhancement”

JUST SAY NO----

if a vaccine is a requirement to get another $1200 i'll do it

From another thread I started a month ago.

ADE

This is the BIG one in my opinion.

-ADE could explain why there are much higher case fatality rates among older populations.

-ADE could also spell why COVID19 could wipeout everything. And I do mean everything.

-ADE could also mean that no vaccine could be developed for SARS-CoV-2 which is the virus that causes COVID19.

What is ADE?

Antibody Dependent Enhancement.

Antibody-dependent enhancement of virus infection and disease.

[link to www.ncbi.nlm.nih.gov (secure)]


“In general, virus-specific antibodies are considered antiviral and play an important role in the control of virus infections in a number of ways. However, in some instances, the presence of specific antibodies can be beneficial to the virus. This activity is known as antibody-dependent enhancement (ADE) of virus infection.”



Antibody-Dependent Enhancement (ADE) of infection and its possible role in the pathogenesis of influenza

[link to www.ncbi.nlm.nih.gov (secure)]

“Antibody-dependent enhancement (ADE) of viral replication has been documented for viruses, such as dengue virus, Ross river virus, other alpha and flaviviruses, HIV and also influenza virus. ADE occurs when non-neutralised virus-antibody complexes find alternative receptors and routes entry into the cell via the Fc-receptor pathway. ADE has been demonstrated predominantly in macrophages or Fc-receptor bearing cells although other types of cells have also been occasionally implicated (1,2). Thus, viruses may find routes of entry to cells lacking the usual virus receptor.”




And here we have a major issue.

Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry.

[link to www.ncbi.nlm.nih.gov (secure)]

“Antibody-dependent enhancement (ADE) of viral entry has been a major concern for epidemiology, vaccine development, and antibody-based drug therapy. However, the molecular mechanism behind ADE is still elusive. Coronavirus spike protein mediates viral entry into cells by first binding to a receptor on the host cell surface and then fusing viral and host membranes....”

Specifically

Is COVID-19 receiving ADE from other coronaviruses?

[link to www.sciencedirect.com (secure)]

And, they know this!


“Studies have suggested that coronavirus vaccines carry the risk of what is known as vaccine enhancement, where instead of protecting against infection, the vaccine can actually make the disease worse when a vaccinated person is infected with the virus. The mechanism that causes that risk is not fully understood and is one of the stumbling blocks that has prevented the successful development of a coronavirus vaccine.”

More later.


——

So, what does ADE mean for vaccine development.

If you read in detail what I’ve posted above, you will understand that vaccine development for SARS-CoV-2 is a perilous endeavor at best and an unattainable goal with our current technology at worst.

This paper highlights just this fact when undertaking the development of SARS-CoV-2 close relative SAR-CoV.
To date, there is no vaccine against SARS and this paper demonstrates different avenues that were investigated to develop a vaccine.

I’m quoting one of several statements in this paper about ADE, SARS, and vaccine safety.

[link to www.ncbi.nlm.nih.gov (secure)]

SARS Vaccine Development


“The S protein of FIPV expressed by recombinant vaccinia can cause antibody-dependent enhancement of disease if vaccinated animals are subsequently infected with wild-type virus (32). Our previous studies on HIV-1 showed that antibodies against some immunodominant epitopes in the HIV-1 envelope glycoprotein could enhance infection by heterologous HIV-1 strains (33). Most recently, Yang et al. (6) demonstrated that the polyclonal and monoclonal antibodies against S protein of the late SARS-CoV (Urbani strain) could neutralize infection by the relevant late SARS-CoV strains. However, these antibodies enhanced infection by an early human SARS-CoV isolate (GD03T0013) and the civet SARS-CoV–like viruses. “


———

What does ADE have to do with increased CFR among older populations?

We will go back to this paper.

Is COVID-19 receiving ADE from other coronaviruses?

[link to www.sciencedirect.com (secure)]

“ADE modulates the immune response and can elicit sustained inflammation, lymphopenia, and/or cytokine storm, one or all of which have been documented in severe cases and deaths. ADE also requires prior exposure to similar antigenic epitopes, presumably circulating in local viruses, making it a possible explanation for the observed geographic limitation of severe cases and deaths.”

And, here is where it gets interesting.

Everything I’ve posted up to this point has been backed by research and this is where I diverge into the theoretical, although there has been some solid evidence this could be true posted prior to this assertion.


The Common Cold

Repeated prior exposure to other Corona Virus types and the antibodies the immune system has produced over the course of one’s lifetime could be driving these higher death rates.

As mentioned earlier, there are several common colds that are corona viruses.

Older populations have much higher exposure rates and in turn more antibodies to these common cold viruses.

I believe COVID-19 exploits these antibodies through ADE to gain entry at a much higher rate, is more infective, and more lethal due to this mechanism in these older populations.

———

What does all of this mean for our future?

Nobody is taking a vaccine. Loose that though government peeps.. it ain’t happening

Nop, not even then. I don't accept extortion.

THIS ^^^^^

AND MANY DEATHS WORLD WIDE.

NO!!!

NOT EVEN ONCE.

Vaccines are mean. Kill them with memes!

Immune Enhancement:

"Researchers need to understand in particular whether the vaccine causes the same types of immune system malfunctions that have been observed in past vaccine development. Since the 1960s, tests of vaccine candidates for diseases such as dengue, respiratory syncytial virus (RSV), and severe acute respiratory syndrome (SARS) have shown a paradoxical phenomenon: Some animals or people who received the vaccine and were later exposed to the virus developed more severe disease than those who had not been vaccinated (1). The vaccine-primed immune system, in certain cases, seemed to launch a shoddy response to the natural infection. “That is
something we want to avoid,” says Kanta Subbarao, director of the World Health Organization Collaborating Centre for Reference and Research on Influenza in Melbourne, Australia.

This immune backfiring, or so-called immune enhancement, may manifest in different ways such as antibody-dependent enhancement (ADE)...."


[link to www.pnas.org (secure)]

Vaccines. They've got what immune systems crave.

Who cares, just test it on all the black folk first

How do you have animal trials when the virus is not transmitted to animals.

This is the human corona virus.

Spazzed out 0.01% puppet

They already have a vaccine. They created the vaccine when they created the virus. It's like what John Roberts said on the hot mic "we've already been vaccinated".

Of course, they get the REAL vaccine, for whatever good it does, we get the FAKE, POISONOUS one.

It must suck to be a ferret during a human pandemic ...

[link to www.wormsandgermsblog.com (secure)]

Why a vaccine?

There's no need for an invasive poison injection.

Hydroxychloroquine/azithromycin/zinc sulfate is the treatment for ONLY those who require it.




Class over.

That's that bitch who used to get his ass beat in grade school!


fuck bill gates

Also, I'm old enough to remember the fake Swine Flu Epidemic of Gerald Ford's time, around 1975, where they kept pushing how deadly the Swine Flu was (it wasn't) and for all the dummies to take the vaccine. Many did. A lot of people died and many developed something called Guillaume Barre Syndrome (GBS) that caused varying degrees of paralysis. There are probably still people out there with GBS from the Swine Flu vaccines.

PLEASE DON'T TAKE THIS SHIT.

no. Researchers found out before all of this that
Covid-19 was transmissible, maybe, almost, to all animals.

They did the same thing with the fake Swine Flu Epidemic in Gerald Ford's admin - see my post above.

yikes that probably means autoimmune reactions.. And let me tell you autoimmune diseases are not nice at all. can make you come out in massive blisters and boils if you get off very lightly.

Covid-19 is exhibiting some scary characteristics,
which really freaks-out the experts.

OP. I think the title of your thread is gonna get you a lot of 1 stars. They think immune enhancement is a good thing.

Rushed Vaccine could will lead to immune enhancement “second wave”
Fixed

a punch of idiots running around like donkies decide on how to control a virus that mutates every 5 minutes

better ask the HIV Noble prize winner and learn that nothing will ever help

what a punch of idiot politicians

lol, natural selection in action, let them have it

Last Edited by Catseye on 05/04/2020 09:21 AM

well, it's true you have to read carefully, but contrary to
the name of the syndrome, none of the experts think
"Immune Enhancement" is a good thing at all.