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NEW: National Institutes of Health has halted a large clinical trial of hydroxychloroquine after finding no benefit to coronavirus patients

 
Anonymous Coward
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06/21/2020 06:57 PM
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NEW: National Institutes of Health has halted a large clinical trial of hydroxychloroquine after finding no benefit to coronavirus patients
The National Institutes of Health has halted its clinical trial of the anti-malaria drug hydroxychloroquine after finding that the treatment provides no benefit to COVID-19 patients.

The decision to end the trial comes after the Food and Drug Administration revoked emergency use of the drug on Monday and the World Health Organization dropped the drug from its global study on Wednesday.

“A data and safety monitoring board met late Friday and determined that while there was no harm, the study drug was very unlikely to be beneficial to hospitalized patients with COVID-19,” the NIH said in a statement on Saturday.

The FDA has also determined the drug is “unlikely to be effective in treating COVID-19” and warned of side effects including serious heart rhythm problems.

Hydroxychloroquine is used to treat malaria and rheumatoid conditions like arthritis. The drug generated excitement earlier in the year after a few small studies suggested it could be beneficial for treating coronavirus.

However, larger studies showed the drug was not helpful and caused heart issues in some patients, and a study in the New England Journal of Medicine found hydroxychloroquine didn’t work any better than a placebo in preventing coronavirus infections.

[link to www.cnbc.com (secure)]
Anonymous Coward (OP)
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06/21/2020 07:00 PM
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Re: NEW: National Institutes of Health has halted a large clinical trial of hydroxychloroquine after finding no benefit to coronavirus patients
NIH Notice:
A clinical trial to evaluate the safety and effectiveness of hydroxychloroquine for the treatment of adults hospitalized with coronavirus disease 2019 (COVID-19) has been stopped by the National Institutes of Health. A data and safety monitoring board (DSMB) met late Friday and determined that while there was no harm, the study drug was very unlikely to be beneficial to hospitalized patients with COVID-19. After its fourth interim analysis the DSMB, which regularly monitors the trial, recommended to the National Heart, Lung, and Blood Institute (NHLBI), part of NIH, to stop the study. NHLBI halted the trial immediately.

The Outcomes Related to COVID-19 treated with hydroxychloroquine among In-patients with symptomatic Disease study, or ORCHID Study, was being conducted by the Prevention and Early Treatment of Acute Lung Injury (PETAL) Clinical Trials Network of NHLBI. The data from this study indicate that this drug provided no additional benefit compared to placebo control for the treatment of COVID-19 in hospitalized patients.

The first participants enrolled in the trial in April at Vanderbilt University Medical Center, Nashville, Tennessee, one of dozens of centers in the PETAL Network. The blinded, placebo-controlled randomized clinical trial aimed to enroll more than 500 adults who are currently hospitalized with COVID-19 or in an emergency department with anticipated hospitalization. More than 470 were enrolled at the time of study’s closure.

All participants in the study received clinical care as indicated for their condition. Those randomized to the experimental intervention had also received hydroxychloroquine. Participants in the study will now continue to receive standard of care and follow up as indicated for their condition.

ORCHID participants had been randomly assigned to receive hydroxychloroquine 400 mg twice daily for two doses (day one), then 200 mg twice daily for the subsequent eight doses (days two to five) or a placebo twice daily for five days.

[link to www.nih.gov (secure)]
Anonymous Coward
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06/21/2020 07:09 PM
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Re: NEW: National Institutes of Health has halted a large clinical trial of hydroxychloroquine after finding no benefit to coronavirus patients
This was a blinded, placebo-controlled randomized clinical trial. Not some faked study by a French quack with 12 carefully selected patients, which is apparently what started all this.
Anonymous Coward
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06/21/2020 07:11 PM
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Re: NEW: National Institutes of Health has halted a large clinical trial of hydroxychloroquine after finding no benefit to coronavirus patients
WITHOUT ZINC AND ZPACK IT DOESN'T WORK....
IT SEEMS THE EXACT SETUP FOR THIS IS NOT CLEAR IN THE ARTICLE
Anonymous Coward
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06/21/2020 07:50 PM
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Re: NEW: National Institutes of Health has halted a large clinical trial of hydroxychloroquine after finding no benefit to coronavirus patients
As hydroxychloroquine fades in the rear view mirror, I wonder if we will hear Donald Trump call this a game changing miracle drug again?
Anonymous Coward
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06/21/2020 08:00 PM
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Re: NEW: National Institutes of Health has halted a large clinical trial of hydroxychloroquine after finding no benefit to coronavirus patients
The National Institutes of Health has halted its clinical trial of the anti-malaria drug hydroxychloroquine after finding that the treatment provides no benefit to COVID-19 patients.

The decision to end the trial comes after the Food and Drug Administration revoked emergency use of the drug on Monday and the World Health Organization dropped the drug from its global study on Wednesday.

“A data and safety monitoring board met late Friday and determined that while there was no harm, the study drug was very unlikely to be beneficial to hospitalized patients with COVID-19,” the NIH said in a statement on Saturday.

The FDA has also determined the drug is “unlikely to be effective in treating COVID-19” and warned of side effects including serious heart rhythm problems.

Hydroxychloroquine is used to treat malaria and rheumatoid conditions like arthritis. The drug generated excitement earlier in the year after a few small studies suggested it could be beneficial for treating coronavirus.

However, larger studies showed the drug was not helpful and caused heart issues in some patients, and a study in the New England Journal of Medicine found hydroxychloroquine didn’t work any better than a placebo in preventing coronavirus infections.

[link to www.cnbc.com (secure)]
 Quoting: Anonymous Coward 79058014


Bs
R&y

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06/21/2020 08:53 PM
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Re: NEW: National Institutes of Health has halted a large clinical trial of hydroxychloroquine after finding no benefit to coronavirus patients
WITHOUT ZINC AND ZPACK IT DOESN'T WORK....
IT SEEMS THE EXACT SETUP FOR THIS IS NOT CLEAR IN THE ARTICLE
 Quoting: Anonymous Coward 77876249


The trial was purposely designed to fail.

There are threads on GLP about this.
Anonymous Coward
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06/22/2020 02:55 PM
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Re: NEW: National Institutes of Health has halted a large clinical trial of hydroxychloroquine after finding no benefit to coronavirus patients
WITHOUT ZINC AND ZPACK IT DOESN'T WORK....
IT SEEMS THE EXACT SETUP FOR THIS IS NOT CLEAR IN THE ARTICLE
 Quoting: Anonymous Coward 77876249


The trial was purposely designed to fail.

There are threads on GLP about this.
 Quoting: R&y


LOL

bert-facepalm
Anonymous Coward
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06/22/2020 02:59 PM
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Re: NEW: National Institutes of Health has halted a large clinical trial of hydroxychloroquine after finding no benefit to coronavirus patients
So Trump was wrong.
Anonymous Coward
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06/23/2020 02:11 PM
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Re: NEW: National Institutes of Health has halted a large clinical trial of hydroxychloroquine after finding no benefit to coronavirus patients
“Game changer”

“Miracle drug”

Oh well.

1rof1
LouisianaGirl40

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06/24/2020 02:40 PM
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Re: NEW: National Institutes of Health has halted a large clinical trial of hydroxychloroquine after finding no benefit to coronavirus patients
“Game changer”

“Miracle drug”

Oh well.

1rof1
 Quoting: Anonymous Coward 78448621


Its all about money. NiH and Fauci are all about vaccine money. Look into links for Fauci and NiH to Bill Gates.

Can't have a cheap, readily available drug for a cure when they could microchip you for your "digital vaccine certificate". Think Windows "patches" only you'd have many versions of a vaccine you'd have to get to be current. Aka allowed in public.
Anonymous Coward
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06/24/2020 02:42 PM
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Re: NEW: National Institutes of Health has halted a large clinical trial of hydroxychloroquine after finding no benefit to coronavirus patients
“Game changer”

“Miracle drug”

Oh well.

1rof1
 Quoting: Anonymous Coward 78448621


Its all about money. NiH and Fauci are all about vaccine money. Look into links for Fauci and NiH to Bill Gates.

Can't have a cheap, readily available drug for a cure when they could microchip you for your "digital vaccine certificate". Think Windows "patches" only you'd have many versions of a vaccine you'd have to get to be current. Aka allowed in public.
 Quoting: LouisianaGirl40


So of course, in order to support your “Bill Gates wants to slip me a chip” conspiracy theory, then Gates also rigged this NIH clinical trial?
Anonymous Coward
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06/24/2020 03:08 PM
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Re: NEW: National Institutes of Health has halted a large clinical trial of hydroxychloroquine after finding no benefit to coronavirus patients
and yet we have multiples of other studies who disagree with these guys. what this means is someone is lying.
Anonymous Coward
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06/24/2020 03:09 PM
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Re: NEW: National Institutes of Health has halted a large clinical trial of hydroxychloroquine after finding no benefit to coronavirus patients
“Game changer”

“Miracle drug”

Oh well.

1rof1
 Quoting: Anonymous Coward 78448621


Its all about money. NiH and Fauci are all about vaccine money. Look into links for Fauci and NiH to Bill Gates.

Can't have a cheap, readily available drug for a cure when they could microchip you for your "digital vaccine certificate". Think Windows "patches" only you'd have many versions of a vaccine you'd have to get to be current. Aka allowed in public.
 Quoting: LouisianaGirl40


So of course, in order to support your “Bill Gates wants to slip me a chip” conspiracy theory, then Gates also rigged this NIH clinical trial?
 Quoting: Anonymous Coward 77963055




If you are a democrat, please get your vaxx + 5G chip impalnt asap. that way you can quit your dam whining that we wont wear your stupid hoax mask.
Anonymous Coward
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06/29/2020 09:43 PM
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Re: NEW: National Institutes of Health has halted a large clinical trial of hydroxychloroquine after finding no benefit to coronavirus patients
“Game changer”

“Miracle drug”

Oh well.

1rof1
 Quoting: Anonymous Coward 78448621


Yes. Such a game changer, in fact, that doctors are trying to get an injunction to release the government stores of HCL to the public.

[link to aapsonline.org (secure)]
Anonymous Coward
User ID: 1932201
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06/29/2020 09:47 PM
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Re: NEW: National Institutes of Health has halted a large clinical trial of hydroxychloroquine after finding no benefit to coronavirus patients
If youse people believe ths ssssssss then shame on you NIH is supported by the one and only Dr Death Dr Fauci himself.This man has been killing people with vaccines since the days of Ronald Reagan.





GLP