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REGENERON uses embryonic stem cells in research

 
Anonymous Coward
User ID: 75920052
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10/05/2020 09:00 AM
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REGENERON uses embryonic stem cells in research
Anonymous Coward
User ID: 79322861
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10/05/2020 09:04 AM
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Re: REGENERON uses embryonic stem cells in research
the nurses will ask a new mother if she will donate her umbilical stem/blood and then she has to sign a paper...
Anonymous Coward (OP)
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10/05/2020 09:11 AM
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Re: REGENERON uses embryonic stem cells in research
the nurses will ask a new mother if she will donate her umbilical stem/blood and then she has to sign a paper...
 Quoting: Anonymous Coward 79322861


[link to stemcell.ny.gov (secure)]


Embryonic stem cells (ESCs) are derived from the embryo and have the potential to become all the different cell types of the body (pluripotency). Somatic stem cells, sometimes called adult stem cells, are found in organs or tissues, can self-renew and yield the differentiated cell types comprising that organ or tissue (multipotency), and are important for maintenance and repair of the organ or tissue. Cord blood stem cells can be isolated from the umbilical cord of newborn infants and are less mature than adult stem cells. Cord blood stem cells are a type of somatic stem cell. Somatic stem cells are restricted in the types of cells they can produce in the lab.
Anonymous Coward
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10/05/2020 09:26 AM
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Re: REGENERON uses embryonic stem cells in research
I’ve donated all the stem cells they’ve wanted from my seven children.

;)
Anonymous Coward (OP)
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10/05/2020 09:27 AM
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Re: REGENERON uses embryonic stem cells in research
I’ve donated all the stem cells they’ve wanted from my seven children.

;)
 Quoting: Anonymous Coward 79438201


Again, different cells.
Anonymous Coward
User ID: 78471403
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10/05/2020 09:30 AM
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Re: REGENERON uses embryonic stem cells in research
No offense but Trump probably has no clue what a stem cell is for crying out loud we are talking about the same genius that said during his 4th of July speech that airplanes liver water airports during the Revolutionary War so let’s be real about the situation
Anonymous Coward
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10/05/2020 09:31 AM
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Re: REGENERON uses embryonic stem cells in research
No offense but Trump probably has no clue what a stem cell is for crying out loud we are talking about the same genius that said during his 4th of July speech that airplanes LIBERATED airports during the Revolutionary War so let’s be real about the situation
 Quoting: Anonymous Coward 78471403
Anonymous Coward (OP)
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10/05/2020 09:39 AM
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Re: REGENERON uses embryonic stem cells in research
Yeah, let's NOT kid ourselves.

Even if Trump actually cared about aborted babies, he'd still take any experimental med containing them that would save his life.
Sungaze_At_Dawn

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10/05/2020 10:08 AM
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Re: REGENERON uses embryonic stem cells in research
They can turn skin cells into stem cells, they don't need embryo stem cells for anything.

[link to www.sciencedaily.com (secure)]
The Devil tries to convince everyone he doesn't exist.
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Anonymous Coward
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10/05/2020 10:13 AM
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Re: REGENERON uses embryonic stem cells in research
encourage murder to feed vampires...
Anonymous Coward
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10/05/2020 08:35 PM
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Re: REGENERON uses embryonic stem cells in research
 Quoting: Anonymous Coward 75920052


hesright
Anonymous Coward
User ID: 75918347
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10/06/2020 08:03 AM
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Re: REGENERON uses embryonic stem cells in research
bump
Anonymous Coward
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10/06/2020 08:26 AM
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Re: REGENERON uses embryonic stem cells in research
Dont try and make a big deal about this when women like Sandra Bullock and other vain female celebrities all over the world, use face creams made with babies foreskin stemcells.
Anonymous Coward
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10/06/2020 08:48 AM
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Re: REGENERON uses embryonic stem cells in research
Dont try and make a big deal about this when women like Sandra Bullock and other vain female celebrities all over the world, use face creams made with babies foreskin stemcells.
 Quoting: Anonymous Coward 79393931


who is making a bih deal out of it.

making money from aborted babies is what every trump supporter wish could do.
Bright Side

User ID: 79038376
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10/07/2020 05:10 AM
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Re: REGENERON uses embryonic stem cells in research
[link to investor.regeneron.com (secure)]

Once again FAKE News.

It would appear while the company REGENERON does employ the use of foetal stem cells in other research it is not used in the cocktail Trump used.

Also, remember Trump severely limited access to foetal stem cells in 2019 essentially limiting it to research already in the pipeline. Since SARS-COV 2 was not even a "thing" yet it's unlikely it was included in current research.

Your assumption based on the companies occasionsl use of embryonic stem cells in some of their research does not correlate to the specific drug Trump received.

Nice try though.

Last Edited by Bright Side on 10/07/2020 05:14 AM
You're the only one who gets to choose your vision... is the glass half empty or half full?

Ps.55:22 Give your burdens to the LORD, and he will take care of you. He will not permit the godly to slip and fall.
Bright Side

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10/07/2020 05:20 AM
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Re: REGENERON uses embryonic stem cells in research
[link to investor.regeneron.com (secure)]

Once again FAKE News.

It would appear while the company REGENERON does employ the use of foetal stem cells in other research it is not used in the cocktail Trump used.

Also, remember Trump severely limited access to foetal stem cells in 2019 essentially limiting it to research already in the pipeline. Since SARS-COV 2 was not even a "thing" yet it's unlikely it was included in current research.

Your assumption based on the companies occasionsl use of embryonic stem cells in some of their research does not correlate to the specific drug Trump received.

Nice try though.
 Quoting: Bright Side


Furthermore it would appear the embryonic stem cells employed are MOUSE stem cells not human.

[link to www.sec.gov (secure)]
You're the only one who gets to choose your vision... is the glass half empty or half full?

Ps.55:22 Give your burdens to the LORD, and he will take care of you. He will not permit the godly to slip and fall.
Mick G
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10/08/2020 05:23 PM
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Re: REGENERON uses embryonic stem cells in research
From what I have read from several sources the anti-body cocktail was tested using "immortalized embryonic kidney cells from an aborted fetus from the 1970's. Cells apparently have been "grown" to force them to divide and reproduce over a long period.
Anonymous Coward
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10/08/2020 05:29 PM
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Re: REGENERON uses embryonic stem cells in research
Here is one of the articles I found:
[link to heavy.com (secure)]

Mick

Getty

President Donald Trump returns to the White House from Walter Reed National Military Medical Center on October 5, 2020. His antibody cocktail did not use human fetal cells.
Rumors are circulating claiming that President Donald Trump‘s monoclonal antibody treatment from Regeneron was made with human fetal or embryonic stem cells. Regeneron told Heavy that their antibody cocktail was not developed using human fetal or embryonic stem cells, but it did use “immortalized epithelial cells” that were originally derived from human embryonic kidney cells at Stanford in the 1980s. Regeneron told Heavy that these were “immortalized epithelial cells” and not stem cells. These cells weren’t used to create the antibody cocktail itself, but they were used to test its potency.
Here’s what you need to know:

REGN-COV2 Was Not Made With Human Stem Cells, Regeneron Says


Alexandra Bowie of Regeneron told Heavy that Regeneron did not create its REGN-COV2 treatment using human embryonic stem cells.
She wrote: “This particular discovery program (REGN-COV2) did not involve human stem cells or ESCs.”
According to a September 29 statement from Regeneron, the antibody cocktail has been shown to reduce viral load and alleviate symptoms in non-hospitalized patients. It’s showing positive trends in reducing medical visits, according to Regeneron. Regeneron wrote: “This trial is part of a larger program that also includes studies of REGN-COV2 for the treatment of hospitalized patients, and for prevention of infection in people who have been exposed to COVID-19 patients.”

The HEK293T Cells Are ‘Immortalized Epithelial Cells,’ Not Stem Cells, Regeneron Says
Another question circulating involves the use of HEK293T cells in the production of the REGN-COV2 antibody cocktail. Two publications in Science Magazine discussed the creation of antibody cocktails for SARS-CoV-2 and mentioned HEK293T cells.
Bowie clarified for Heavy how the HEK293T cells were used:
They are referring to use of the 293T cell line, which was made at Stanford in the ‘80s and was originally derived from human embryonic kidney cells. These are immortalized epithelial cells – not stem cells. These are very commonly used cells in research, and most published research involves use of 293s. In our case, these 293T cells were transfected and used in production of a ‘pseudoparticle’ that mimics the virus’ Spike protein and allowed us to test neutralization ability of our antibodies against the virus.

Tests for the Potency of Regeneron’s Antibodies Used HEK 293T Cells

Regeneron told Technology Review that the HEK 293T cells weren’t used to create the antibody cocktail itself, but they were used to test the potency of the antibodies. The HEK 293T cells originated from kidney tissue from an abortion in the Netherlands in the 1970s. The cells have been dividing in a lab (thus “immortalized”) since the 1970s, Technology Review noted.
You can see a description of the 293T cell line here, provided on the Millipore Sigma website. It notes:
293T cell line is a stable clone derivative of the human embryonic kidney (HEK) 293 cell line. It expresses the large T antigen of simian virus 40 (SV40)… The 293T cell line was created in the laboratory of Michele Calos by transfection of a sub-line of adenovirus-immortalized human embryonic kidney cells with a gene encoding the SV40T-antigen and a neomycin resistance gene. The cell line is competent for replication of vectors carrying the SV40 origin of replication. The line also has favourable tissue culture, transfection, DNA replication, gene expression, and protein production properties. It gives high titres when used to produce many viral vectors such as oncoretroviruses and lentiviruses… HEK293T is used for large-scale vector production, displays increased cell growth and is efficient for transfection experiments when compared to HEK293 cells.”
Regeneron told Technology Review and Heavy that many labs use these 293T cells to create virus-like particles with a spike protein similar to SARS-CoV-2.
Bowie told Technology Review that the cell lines aren’t considered fetal tissue because they are divided cells that grew from a cell line from the 1970s.

Bowie told Technology Review: “It’s how you want to parse it. But the 293T cell lines available today are not considered fetal tissue, and we did not otherwise use fetal tissue.”
Heavy is reaching out to scientific experts for more information and will update this story once that information is available.

Some People Misinterpreted a General Statement From Regeneron About Stem Cell Use
The rumor started when people misread a position statement on stem cell treatment released by Regeneron and misinterpreted it as being about the drug in particular. Bowie told Heavy that this was their general position on stem cell use and was not an indication of how that particular monoclonal antibody treatment was created.
Here’s a screenshot of one of the many rumors circulating on social media.

People are sharing posts with misinformation claiming that Trump’s monoclonal antibodies were made from fetal stem cells. This is not accurate.
Some of the rumors cite the position statement from Regeneron about stem cell research, which you can read here or below. This statement was released in April 2020.


Regeneron
The Regeneron statement that helped spark online rumors.

The statement read, in part:
As is the case with many other science-focused biotechnology companies, Regeneron uses a wide variety of research tools and technologies to help discover and develop new therapeutics. Stem cells are one such tool. The stem cells most commonly used at Regeneron are mouse embryonic stem cells and human blood stem cells. Currently, there are limited research efforts employing human-induced pluripotent stem cell lines derived from adult human cells and human embryonic stem cells that are approved for research use by the National Institutes of Health and created solely through in vitro fertilization. Research using such stem cells allows Regeneron to model complex diseases, test new drug candidates and can help unlock new scientific insights that ultimately could lead to the discovery of new treatments for people with serious diseases.

All of Regeneron’s research conducted on stem cells adheres to federal and state laws and regulations. Regeneron demands from its collaborators and vendors that all human stem cell lines used in its research are from properly consented individuals.

George D. Yancopoulos, M.D., Ph.D. and president and chief scientific officer of Regeneron, talked about the new antibody cocktail in a September 24 press statement. He said, in part:

The greatest treatment benefit was in patients who had not mounted their own effective immune response, suggesting that REGN-COV2 could provide a therapeutic substitute for the naturally-occurring immune response. These patients were less likely to clear the virus on their own, and were at greater risk for prolonged symptoms. We are highly encouraged by the robust and consistent nature of these initial data, as well as the emerging well-tolerated safety profile, and we have begun discussing our findings with regulatory authorities while continuing our ongoing trials.

In addition to having positive implications for REGN-COV2 trials and those of other antibody therapies, these data also support the promise of vaccines targeting the SARS-CoV-2 spike protein.
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