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Calling bullshit on anyone who says MRNA can’t make permanent changes to the genome ... here is proof.

 
Anonymous Coward
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03/06/2021 10:43 AM
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Calling bullshit on anyone who says MRNA can’t make permanent changes to the genome ... here is proof.
[link to www.sciencemag.org (secure)]



A second big difference between vaccines and mRNA therapeutics is that vaccines require just one or a few doses. Once the immune system is trained to attack the threat at hand, the protein produced from mRNA degrades and doesn’t need replenishment. For the most part, the mRNA drugs that have advanced into clinical trials so far are ones “where the effect of the drug outlasts the drug,” Dahlman says. That’s also true for therapies that use mRNA to encode proteins such as the enzyme Cas9, which can slice the genome to make permanent edits. CRISPR editing company Intellia Therapeutics is advancing one such mRNA-based therapy for the inherited disease transthyretin amyloidosis. The company dosed its first clinical trial participant last month.

[link to www.thermofisher.com (secure)]



Cas9 mRNA is co-transfected with a target-specific guide RNA (gRNA) to direct the Cas9 protein to the intended genome locus to create a double-stranded break. The complete RNA format is a smaller payload than plasmid-based Cas9 systems for improved delivery into the cell and better genome editing efficiency.
Swamprat

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03/06/2021 12:16 PM
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Re: Calling bullshit on anyone who says MRNA can’t make permanent changes to the genome ... here is proof.
I don't know if anybody is actually thinking about the ramifications beyond trying to use this as a scare technique.

This is amazing.

Tremendous potential.
We aren't cut out to be socialists.We are the people who couldn't be constrained by Europe. We are the malcontents, idealists, speculators, dreamers, inventors, debtors and criminals who would not be chained. We don't play well with others, we are brash, outlandish and cunning. let us do what we do best; let us be Americans.





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