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FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects

 
Anonymous Coward
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02/29/2024 05:26 PM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
S-man you say early variants used Furin cleavage to attack directly via ACE2. Then what does Omicron use?

Maybe Omicron is worse because blood pressure medication (ace2 inhibitors) could protect heart against earlier variants for which it is useless against Omicron.
 Quoting: Anonymous Coward 82276662


Sorry, NED, I missed this.

Omicron uses mainly endocytosis - like common cold /flu - to get into cells. That's why HCQ is so effective against it (cathepsin blocker).

Other routes into cells are receptors like NEUROPILIN1, cholinergic receptors like nAChR, CD147, DC-SIGN... but nothing is as efficient as that QTQTNSPRRAR segment in variants prior to Omicron.

The ACE2 receptor is still latched onto by Omicron, but it does not help the virus as much, as it cannot cleave the membrane with Furin like it used to.
 Quoting: S-man




A complicated substack hinting at pathological mechamisms involving Spike+CypA, CD147.
Same receptor as Malaria (treatable with HCQ).

I wonder if we'll ever get round to approving HCQ for covid?


[link to hiddencomplexity.substack.com (secure)]
The hidden pathways of SARS-CoV-2
Beyond the Spike - CypA, CD147, RAGE

The short of it, CypA, a protein expressed “everywhere” interacts with the Spike Protein, it increases its membrane fusion, and it participates and helps infectivity, and transmission of the virus.

CypA has a widely known receptor. Basigin. EMMPRIN (Extracellular Matrix Metalloproteinase Inducer).
But most commonly known as CD147.

The interaction between soluble CypA (floating around) and CD147 can both create and accelerate cancer. It also plays a role in neurodegeneration, and Alzheimer’s. Coronary Arterial (heart) diseases. It can augment thrombosis and its cascading inflammation. Kidney disease. Lung disease. Endothelial cell activation and dysfunction.

exposure to Endotoxin (LPS) increases the expression of both CypA and CD147.

(My note: jabs were contaminated with LPS if they had E.Coli remains in them, which we know they did!)

Early in the pandemic, a few researchers were proposing the interaction of CD147, CypA, and the virus,

Here is a late 2020 paper discussing the disruption of cardiac pericytes and endothelial cells through the CD147 receptor (it caused an uproar back in the day)
[link to www.biorxiv.org (secure)]

Here is a recent paper on SARS-CoV-2 using alternative receptors to induce kidney damage, and one of them is CD147
[link to www.imrpress.com (secure)]

Here we have a recent paper demonstrating that human motor neuron cells (created from pluripotent stem cells) are susceptible to SARS-CoV-2 infection by...CD147.
[link to www.frontiersin.org (secure)]

Another recent paper on how two specific molecules inhibit SARS-CoV-2 entry into Megakaryocytes by targeting CD147.
[link to www.mdpi.com (secure)]
...This one is especially significant because recently a team of researchers found another potential reservoir in Long Covid patients. The bone marrow (where the megaka cells are produced)...

 Quoting: S-man


S-man,

You may have seen this:

[link to www.nature.com (secure)]

Cyclophilin A: a key player for human disease

Abstract

Cyclophilin A (CyPA) is a ubiquitously distributed protein belonging to the immunophilin family. CyPA has peptidyl prolyl cis-trans isomerase (PPIase) activity, which regulates protein folding and trafficking. Although CyPA was initially believed to function primarily as an intracellular protein, recent studies have revealed that it can be secreted by cells in response to inflammatory stimuli. Current research in animal models and humans has provided compelling evidences supporting the critical function of CyPA in several human diseases. This review discusses recently available data about CyPA in cardiovascular diseases, viral infections, neurodegeneration, cancer, rheumatoid arthritis, sepsis, asthma, periodontitis and aging. It is believed that further elucidations of the role of CyPA will provide a better understanding of the molecular mechanisms underlying these diseases and will help develop novel pharmacological therapies.


Among the other things, "protein folding" kinda jumped out.

I've been talking about LPS for about 3 years now.

It is not the only thing going on. It is not even, maybe, the most important thing going on, but it is important, and it is going on.

Like many other things here, it start some dominoes falling so esrly in the chain that by the time they evidence in symptoms and disease, it can show up as many differnt pathologies.

This is another, "not an accident", and, "not natural".
Anonymous Coward
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02/29/2024 05:36 PM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Another thing that could be helpful for people, to pull the vaxx toxins from the body, is castor oil.

It detoxes the body, but you have to be careful and start slowly.

First, it must be organic and hexane free. Store in a brown glass bottle, as it will leach toxins from plastic.

Start by cutting it with another organic oil, I use grapeseed, as the castor oil is very thick. Begin by applying to the abdominal area. Then after a week of so, assuming you have no bad reactions, begin applying to the entire body, every day, after you shower.

If nothing else, it is very good for your skin. Oh, it will stain some, so I keep dark covers on the bed (I shower at night), and sleep commando,much to Mr. LJS's pleasure. It will fully absorb into your skin in an hour, or so.

This is an auravedic detox protocol, and has been used for 5,000 years.

There are people on this thread far more in the know, than I am, of bio-chem as why this works. I just know it works.

It can be taken internally, but be more careful. I take only 1/2 teaspoon per day. Yes, it tastes a bit yucky, but not as yucky a chicona bark extract.

I have been reluctant to share this, as I am not a certified practitioner or a scientist.
 Quoting: LJS

Hope you're doing OK, LJ.

You reminded me to watch one of my favourite films: Mogambo (1953).
Clark Gable, Grace Kelly, Africa, Game hunting...
and this classic line:
"Round here, we have three antidotes for everything. Quinine, Iodine and Castor Oil."
(that line stuck in my mind at the start of the pandemic...!)

The cinchona is a proxy for Quinine / Hydroxychloroquine, btw. - I'm sure you knew that.

Also, the problem as I see it is that as well as detoxing, we have the issue that the body itself may be making these toxins - if integrated into the DNA, then regular detoxing may be the only thing one can do..?

Appreciate the info sharing.
I sleep commando, too. chuckle
Can't stand the feeling of something constricting at night.
 Quoting: S-man


3 good things, still valuable.

RE: Iodine:

I have personally heard a number of older physicians say, or express familiarity with, "If ye don’t know where, what, and why Prescribe ye then K and I"

Extract from:
[link to www.westonaprice.org (secure)]

Iodine was discovered in 1811 and shortly thereafter entered the materia medica. It was used in large amounts until the mid-1900s for treating various dermatologic conditions, chronic lung disease, fungal infestations, tertiary syphilis and even arteriosclerosis.14 The Nobel laureate Dr. Albert Szent Györgi (1893-1986), the physician who discovered vitamin C, wrote: “When I was a medical student, iodine in the form of KI [potassium iodide] was the universal medicine. Nobody knew what it did, but it did something and did something good. We students used to sum up the situation in this little rhyme:

If ye don’t know where, what, and why Prescribe ye then K and I.”15

According to the 11th edition of the Encyclopedia Britannica, published in 1911, the pharmacological action of compounds containing potassium iodide, “is as obscure as their effects in certain diseased conditions are consistently brilliant. Our ignorance of their mode of action is cloaked by the term deobstruent, which implies that they possess the power of driving out impurities from the blood and tissues. Most notably is this the case with the poisonous products of syphilis. In its tertiary stage—and also earlier—this disease yields in the most rapid and unmistakable fashion to iodides, so much so that the administration of these salts is at present the best means of determining whether, for instance, a cranial tumor be syphilitic or not.”
ParamedicUK

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02/29/2024 06:23 PM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Fascinating discussion btw. Kevin McKernan & Pierre Kory/Paul Marik.
AMAZING to watch medical practitioners come to grips with the technicals, and relate it to clinical disease..

17m00s Chimeric peptides - risks - human mitochondrial sequence after the stop codons in Pfizer. Potential for spike-mitochindria 'chimera' proteins.
17m30s Mitochondrial disease from the jabs... WOW. POTS, Dysautonmia, Kory says "yes, YES!"...
18m00s McKernan elaborates: "what if immune system is getting targetted against the mito(chondria), that would be a disaster!"


19m30s "template switching" because of pseudo-uridine, where the mRNA gets read backwards.. big problem in Pfizer bc no stop codons in reverse direction (this is hard to achieve!)!
-> (McKernan equates the lack of stop codons in reverse dir. to having a chapter of the bible that reads ok forwards and in reverse.)

21m30s The entire sequence is amyloidogenic - and this is self-amplifying. Chain reaction. Exponential.

McKernan then goes on to cover the slides he presented above in LostSouls' post, but slower and in more detail...

59m-69m They are taking questions and highlighting ALL the problems and why mRNA is flawed...
1h09m: Dr Paul Marik: "I think it's going to be 10-20 years before we actually realise the full extent of this genetic therapy"




[link to rumble.com]



This health movement / infrastructure is LIGHT YEARS ahead of the establishment, you gotta agree?
We should support it.
 Quoting: S-man


VERY CONCERNING !!!!

The jabbed could be in for a really bad ride.

UK Keep Calm Sma
 Quoting: ParamedicUK


S-man

Back to this video with one of the masters of DNA.

The vaxed could be totally fucked !!!
Herd immunity and vaccine free is the only way……

Peace not War.
S-man

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02/29/2024 06:30 PM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Thanks AC.
I have downloaded the nature paper, scanned the first couple of pages, and will read properly tomorrow.

What stuck out to me, on top of what you highlghted, was the involvement in endothelium, inflammation, vascular remodelling, and the table on p2..

Tale p2 - CypA targets:
==================

-> Folding of HIV-1 Gag.
we know SARS2 has HIV Gag inserts!

-> Folding of Transferrin (we just noted --thanks, JAZZ-- that the Transferrin receptor allows SARS 2 infection of cells!)

-> Folding of at least one nAChR nicotinic receptor, also used by SARS2 for entry.

-> Trafficking by CD147.. as we knew.

-> Trafficking by Zinc-finger protein -- which is important iirc in viral replication, and why Zinc was recommended with HCQ back in the day..

CypA Inflammation, vascular remodelling:-
=================

Key to avoid inflammation as it causes a cascade of issues incl. BBB permeability & neutrophil elastase release (in presence of spike it has been shown that neutrophil elastase makes amyloid fibres!)

CypA promotes vascular remodelling.. I think vascular remodelling is also promoted by spike.. via VEGF.

Interesting that Walter Chesnut ( @ parsifaler) has oft spoken of SARS2 as an endothelial inflammatory disease.

------------

Now I have to sleep!

Last Edited by S-man on 02/29/2024 06:32 PM
S-man

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02/29/2024 06:42 PM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Fascinating discussion btw. Kevin McKernan & Pierre Kory/Paul Marik.
AMAZING to watch medical practitioners come to grips with the technicals, and relate it to clinical disease..

17m00s Chimeric peptides - risks - human mitochondrial sequence after the stop codons in Pfizer. Potential for spike-mitochindria 'chimera' proteins.
17m30s Mitochondrial disease from the jabs... WOW. POTS, Dysautonmia, Kory says "yes, YES!"...
18m00s McKernan elaborates: "what if immune system is getting targetted against the mito(chondria), that would be a disaster!"


19m30s "template switching" because of pseudo-uridine, where the mRNA gets read backwards.. big problem in Pfizer bc no stop codons in reverse direction (this is hard to achieve!)!
-> (McKernan equates the lack of stop codons in reverse dir. to having a chapter of the bible that reads ok forwards and in reverse.)

21m30s The entire sequence is amyloidogenic - and this is self-amplifying. Chain reaction. Exponential.

McKernan then goes on to cover the slides he presented above in LostSouls' post, but slower and in more detail...

59m-69m They are taking questions and highlighting ALL the problems and why mRNA is flawed...
1h09m: Dr Paul Marik: "I think it's going to be 10-20 years before we actually realise the full extent of this genetic therapy"




[link to rumble.com]



This health movement / infrastructure is LIGHT YEARS ahead of the establishment, you gotta agree?
We should support it.
 Quoting: S-man


VERY CONCERNING !!!!

The jabbed could be in for a really bad ride.

UK Keep Calm Sma
 Quoting: ParamedicUK


S-man

Back to this video with one of the masters of DNA.

The vaxed could be totally fucked !!!
 Quoting: ParamedicUK


Yes, six-ways-to-sunday.
I really hope not. But the world hasn't even acknowledged the problems yet. 100% full steam ahead on mRNA therapies/vaxxes.

The video literally blew me away, it covered so much of what is wrong, so concisely. And writ large just how much we don't know.

It's a superb video. Really worth the watch, perhaps the first 17m are a little dull? If watching, stick with it until 1h9m, at least.

OK now I AM off to bed!
Derpp01
Lost Souls

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02/29/2024 06:52 PM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Fascinating discussion btw. Kevin McKernan & Pierre Kory/Paul Marik.
AMAZING to watch medical practitioners come to grips with the technicals, and relate it to clinical disease..

17m00s Chimeric peptides - risks - human mitochondrial sequence after the stop codons in Pfizer. Potential for spike-mitochindria 'chimera' proteins.
17m30s Mitochondrial disease from the jabs... WOW. POTS, Dysautonmia, Kory says "yes, YES!"...
18m00s McKernan elaborates: "what if immune system is getting targetted against the mito(chondria), that would be a disaster!"


19m30s "template switching" because of pseudo-uridine, where the mRNA gets read backwards.. big problem in Pfizer bc no stop codons in reverse direction (this is hard to achieve!)!
-> (McKernan equates the lack of stop codons in reverse dir. to having a chapter of the bible that reads ok forwards and in reverse.)

21m30s The entire sequence is amyloidogenic - and this is self-amplifying. Chain reaction. Exponential.

McKernan then goes on to cover the slides he presented above in LostSouls' post, but slower and in more detail...

59m-69m They are taking questions and highlighting ALL the problems and why mRNA is flawed...
1h09m: Dr Paul Marik: "I think it's going to be 10-20 years before we actually realise the full extent of this genetic therapy"




[link to rumble.com]



This health movement / infrastructure is LIGHT YEARS ahead of the establishment, you gotta agree?
We should support it.
 Quoting: S-man


Looks interesting, I’ll check it out later. Thanks S Man
 Quoting: Lost Souls


Just gotta chance to watch the video. Very interesting and irrefutably damning to say the least. There’s gotta be some way to expedite the process to determine whether integration into the genome is occurring. Also really need to figure out if those endotoxins are present. At the very least, this jab does appear to be a bio weapon that leads to a wide variety of issues.
Dosha

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02/29/2024 11:22 PM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Wow. The CDC really doesn't like old folks flower


The CDC recommended today that everyone 65 and older get an additional dose of the updated 2023-24 COVID booster which "targets the XBB lineage of the Omicron variant." Yet the CDC's own prevalence data shows that the XBB lineage had, as of mid Feb, all but disappeared from circulation.



Dosha
CoronaCoaster2  (OP)

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03/01/2024 04:46 AM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Hi everyone,
weekly greenie request, if you can manage it!
Will be spent on account upgrade, to keep thread sane.
(we've got 61, 100 spent so far).
Guythu

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03/01/2024 05:34 AM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
[link to twitter.com (secure)]

PIERRE POILEVERE: TRUDEAU'S MINISTER GAVE CHINA ACCESS TO CANADA'S VIRUS LABS

"We've just received documents that Trudeu has been covering up for years, documents related to a massive security breach at the Trudeau government's most sensitive laboratory where the most dangerous viruses are studied and handled.

We've learned that the Trudeau government's head of pathogens was collaborating with members of Bejining's People's Liberation Army who are responsible for bioweapons."

Source: Canada Proud
S-man

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03/01/2024 05:47 AM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects


Andrew Bridgen MP
@ABridgen
22h
This morning, I asked @PennyMordaunt for a debate in government time on those who commit crimes against humanity and the appropriate punishment for those people.

The Leader of the House's response says it all! They all know what has and what is being perpetrated against the people
ParamedicUK

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03/01/2024 05:54 AM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects


Andrew Bridgen MP
@ABridgen
22h
This morning, I asked @PennyMordaunt for a debate in government time on those who commit crimes against humanity and the appropriate punishment for those people.

The Leader of the House's response says it all! They all know what has and what is being perpetrated against the people
 Quoting: S-man


There has been a big backlash after that.
Herd immunity and vaccine free is the only way……

Peace not War.
S-man

User ID: 85054723
United States
03/01/2024 06:49 AM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Against Bridgen or Mordaunt?
"Conspiracy Theories" ....pah...
That just means soon-to-be-proven-correct, yes?

So weak.
So predictable.
So utterly boring.
So establishment.
So NOT representing the people.
So deserving of what is surely coming.

Last Edited by S-man on 03/01/2024 06:51 AM
LJSModerator
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03/01/2024 09:11 AM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Wow. The CDC really doesn't like old folks flower


The CDC recommended today that everyone 65 and older get an additional dose of the updated 2023-24 COVID booster which "targets the XBB lineage of the Omicron variant." Yet the CDC's own prevalence data shows that the XBB lineage had, as of mid Feb, all but disappeared from circulation.



 Quoting: Dosha


I still know people who can't wait to line up for the latest rendition. SMH

I also know several doctors and nurses who refuse to ever take any such vaxx again.
Fate whispers to the warrior

"You cannot withstand the storm"

the warrior whispers back

"I am the storm"

INTJ-A

Killer Bunny
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03/01/2024 09:12 AM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Hi everyone,
weekly greenie request, if you can manage it!
Will be spent on account upgrade, to keep thread sane.
(we've got 61, 100 spent so far).
 Quoting: CoronaCoaster2


I'll get you a few more. An admin discretion. Besides, I need you to keep your thread clean -- less work for me. tounge
Fate whispers to the warrior

"You cannot withstand the storm"

the warrior whispers back

"I am the storm"

INTJ-A

Killer Bunny
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03/01/2024 09:21 AM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Another thing that could be helpful for people, to pull the vaxx toxins from the body, is castor oil.

It detoxes the body, but you have to be careful and start slowly.

First, it must be organic and hexane free. Store in a brown glass bottle, as it will leach toxins from plastic.

Start by cutting it with another organic oil, I use grapeseed, as the castor oil is very thick. Begin by applying to the abdominal area. Then after a week of so, assuming you have no bad reactions, begin applying to the entire body, every day, after you shower.

If nothing else, it is very good for your skin. Oh, it will stain some, so I keep dark covers on the bed (I shower at night), and sleep commando,much to Mr. LJS's pleasure. It will fully absorb into your skin in an hour, or so.

This is an auravedic detox protocol, and has been used for 5,000 years.

There are people on this thread far more in the know, than I am, of bio-chem as why this works. I just know it works.

It can be taken internally, but be more careful. I take only 1/2 teaspoon per day. Yes, it tastes a bit yucky, but not as yucky a chicona bark extract.

I have been reluctant to share this, as I am not a certified practitioner or a scientist.
 Quoting: LJS

Hope you're doing OK, LJ.

You reminded me to watch one of my favourite films: Mogambo (1953).
Clark Gable, Grace Kelly, Africa, Game hunting...
and this classic line:
"Round here, we have three antidotes for everything. Quinine, Iodine and Castor Oil."
(that line stuck in my mind at the start of the pandemic...!)

The cinchona is a proxy for Quinine / Hydroxychloroquine, btw. - I'm sure you knew that.

Also, the problem as I see it is that as well as detoxing, we have the issue that the body itself may be making these toxins - if integrated into the DNA, then regular detoxing may be the only thing one can do..?

Appreciate the info sharing.
I sleep commando, too. chuckle
Can't stand the feeling of something constricting at night.
 Quoting: S-man


Since I use all 3 in caution, and moderation, I should be iron woman. chuckle
Fate whispers to the warrior

"You cannot withstand the storm"

the warrior whispers back

"I am the storm"

INTJ-A

Killer Bunny
CoronaCoaster2  (OP)

User ID: 86681113
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03/01/2024 11:10 AM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Hi everyone,
weekly greenie request, if you can manage it!
Will be spent on account upgrade, to keep thread sane.
(we've got 61, 100 spent so far).
 Quoting: CoronaCoaster2


I'll get you a few more. An admin discretion. Besides, I need you to keep your thread clean -- less work for me. tounge
 Quoting: LJS


Work gladly accepted, and many thanks.

I suppose many don't see all the troll posts which get deleted, but they're around!
S-man

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03/01/2024 12:50 PM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
S-man,

You may have seen this:

[link to www.nature.com (secure)]

Cyclophilin A: a key player for human disease

Abstract

Cyclophilin A (CyPA) is a ubiquitously distributed protein belonging to the immunophilin family. CyPA has peptidyl prolyl cis-trans isomerase (PPIase) activity, which regulates protein folding and trafficking. Although CyPA was initially believed to function primarily as an intracellular protein, recent studies have revealed that it can be secreted by cells in response to inflammatory stimuli. Current research in animal models and humans has provided compelling evidences supporting the critical function of CyPA in several human diseases. This review discusses recently available data about CyPA in cardiovascular diseases, viral infections, neurodegeneration, cancer, rheumatoid arthritis, sepsis, asthma, periodontitis and aging. It is believed that further elucidations of the role of CyPA will provide a better understanding of the molecular mechanisms underlying these diseases and will help develop novel pharmacological therapies.


Among the other things, "protein folding" kinda jumped out.

I've been talking about LPS for about 3 years now.

It is not the only thing going on. It is not even, maybe, the most important thing going on, but it is important, and it is going on.

Like many other things here, it start some dominoes falling so esrly in the chain that by the time they evidence in symptoms and disease, it can show up as many differnt pathologies.

This is another, "not an accident", and, "not natural".
 Quoting: Anonymous Coward 77990985



Thanks AC.
I have downloaded the nature paper, scanned the first couple of pages, and will read properly tomorrow.

What stuck out to me, on top of what you highlghted, was the involvement in endothelium, inflammation, vascular remodelling, and the table on p2..

Tale p2 - CypA targets:
==================

-> Folding of HIV-1 Gag.
we know SARS2 has HIV Gag inserts!

-> Folding of Transferrin (we just noted --thanks, JAZZ-- that the Transferrin receptor allows SARS 2 infection of cells!)

-> Folding of at least one nAChR nicotinic receptor, also used by SARS2 for entry.

-> Trafficking by CD147.. as we knew.

-> Trafficking by Zinc-finger protein -- which is important iirc in viral replication, and why Zinc was recommended with HCQ back in the day..

CypA Inflammation, vascular remodelling:-
=================

Key to avoid inflammation as it causes a cascade of issues incl. BBB permeability & neutrophil elastase release (in presence of spike it has been shown that neutrophil elastase makes amyloid fibres!)

CypA promotes vascular remodelling.. I think vascular remodelling is also promoted by spike.. via VEGF.

Interesting that Walter Chesnut ( @ parsifaler) has oft spoken of SARS2 as an endothelial inflammatory disease.

------------

Now I have to sleep!
 Quoting: S-man




Regarding CypA (Cyclophilin A) and its inhibitor CsA (Cyclosporin A), these additions from the paper AC pointed out!
Note: Spike has been found to bind to P53, and CypA (which increases in many cancers) is controlled by p53!!!!!!!


From the nature paper...HIV:
"sera from HIV-1-infected individuals has revealed higher protein concentrations of CyPA (about fourfold) compared with sera of healthy controls"
"Therefore, packaging of host CyPA into HIV particles is an important step in HIV morphogenesis and essential for HIV replication."

Hepatitis-C:
"several lines of evidence indicate that CyPA positively regulates the replication of hepatitis C virus (HCV)"

Flu:
"CyPA was found in the core of the influenza virion"
"overexpression of CyPA blocked influenza A virus replication, whereas the depletion of endogenous CyPA resulted in enhanced production of influenza A virus"

Vaccinia:
"It was reported that vaccinia virus (VV) infection led to an impressive increase in CyPA stability and CyPA is incorporated into the virus particle during morphogenesis"

VSV:
"CyPA was found to act as a chaperone for the nucleocapsid protein of the vesicular stomatitis virus (VSV)"

SARS Classic:
"CyPA was also reported to regulate severe acute respira- tory syndrome coronavirus (SARS-CoV) replication through binding to the nucleocapsid protein and incorporation into particles"

Rotavirus:
"CyPA is required for the host IFN-I response in rotavirus (RV)"

CMV:
"CyPA expression is an important factor in human cytomegalovirus (HCMV) infection and reactivation."

Parasites:
"CyPA seems to be involved in the intracellular replication cycle of Leishmania major parasites, as CyPA siRNA interference or CsA reduced the parasite burden"
"Some of the small CyPs from Plasmodium falciparum and Toxoplasma gondii (i.e. TgCyP18) have shown similar inhibitory profiles as those established for the human CyPA"

Cancer:
"various reports have shown that CyPA is upregulated in cancer and is a key determinant for malignant transformation and metastasis"
"overexpressed CyPA in many cancers: (1) helps cancer proliferation, (2) regulates cell cycle progression, (3) blocks apoptosis, and (4) promotes cell migration/ invasion"
"upregulation of CyPA in cancers was reported to be controlled by p53 and HIF1-alpha"
"CyPA knockdown has a significant effect on tumor growth in vivo"


Neurodegen:
"involvement of CyPA in Alzheimer disease"
"age-dependent progressive blood–brain barrier (BBB) breakdown (Figure 5). This event is driven by CyPA"
"CD147 receptor, by interacting with CyPA, can influence amyloid-beta peptide level"
"Mechanistic insights revealed that CyPA is involved in motor neuronal cell death in ALS model mice"
"CyPA is significantly enriched in the insoluble fraction of spinal cords of ALS patients"
"CyPA as biomarker for ALS in peripheral blood mononuclear cells and find an association with disease progression"
"copper affects the secretion of CyPA"


Rheumatoid Arthritis (RA):
"CyPA was increased in the synovial fluids of RA patients"
"increased expression of CD147 on neutrophils in RA may be responsible for CyPA-mediated neutrophil migration into the joints"

The list continues... Asthma, sepsis, gingivitis ...

THANKS AC!!!


--------------------
(ParaUK: you see the siRNA reference above?!)

Last Edited by S-man on 03/01/2024 12:51 PM
Rasen1
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03/01/2024 12:53 PM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
We are currently battling norovirus over here, many many hospitaisations with it.
 Quoting: Rasen1 72713232


BTW, hello, stranger!
 Quoting: S-man


Hello!
Anonymous Coward
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03/01/2024 12:56 PM
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We are currently battling norovirus over here, many many hospitaisations with it.
 Quoting: Rasen1 72713232


Yes it’s rampant at the moment - but normal Winter vomiting levels I feel so far ?
 Quoting: ParamedicUK


Possibly, maybe just more talking about it this year, there are mutterings up and down other lines about the issue, (ppe requests and so on) I've not heard that being discussed before - because I would have thought that was a given without requesting it?.
Anonymous Coward
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03/01/2024 12:58 PM
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We are currently battling norovirus over here, many many hospitaisations with it.
 Quoting: Rasen1 72713232


It’s ridiculous at work atm 30 people sick at work with it only a few are staying home. Full lines coughing and been sick. Soon as your work next to some one with it a few days later you turn ill.
Headache coughing fatigue knees hurting and been sick. Are the main symptoms people are reporting.
 Quoting: AV 3.0


Yes, I've heard of whole families and workplaces being taken down by it.
ParamedicUK

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03/01/2024 03:10 PM

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We are currently battling norovirus over here, many many hospitaisations with it.
 Quoting: Rasen1 72713232


BTW, hello, stranger!
 Quoting: S-man


Hello!
 Quoting: Rasen1 72713232


Moving away from tummy upsets what are you seeing concerning cancers.

I am starting to get warning signs of turbo cancers.

3 patients in 2 shifts with sudden onset cancer with mets !!!!

Last one having a massive heart attack following previous lung clots !!!! Fully jabbed of course.

It’s starting to flag alarms with me which I haven’t seen in 22 years front line.

We don’t normally see patterns as we go to such a range of jobs but this is starting to worry me.

My father in law recently died of prostatic cancer with spinal mets / fit as a fiddle until the end of last year - fully jabbed.

Most seem breast or prostatic related ????


Eleintheroom

Last Edited by ParamedicUK on 03/01/2024 03:27 PM
Herd immunity and vaccine free is the only way……

Peace not War.
Rasen1
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03/01/2024 05:17 PM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
We are currently battling norovirus over here, many many hospitaisations with it.
 Quoting: Rasen1 72713232


BTW, hello, stranger!
 Quoting: S-man


Hello!
 Quoting: Rasen1 72713232


Moving away from tummy upsets what are you seeing concerning cancers.

I am starting to get warning signs of turbo cancers.

3 patients in 2 shifts with sudden onset cancer with mets !!!!

Last one having a massive heart attack following previous lung clots !!!! Fully jabbed of course.

It’s starting to flag alarms with me which I haven’t seen in 22 years front line.

We don’t normally see patterns as we go to such a range of jobs but this is starting to worry me.

My father in law recently died of prostatic cancer with spinal mets / fit as a fiddle until the end of last year - fully jabbed.

Most seem breast or prostatic related ????


:Eleintheroom:
 Quoting: ParamedicUK


Lots of cancers which are quickly spreading all over the body.Mostly elderly.

Lots of fatal heart attacks.Different ages.
JAZZz50

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03/01/2024 05:27 PM

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will i get spanked and kicked out for posting TM news again? this time it'll probly b longer too.
JAZZZ50

2020 The SHTF literally as TP ran out.

we went from being over the target, to actually being the target. too close to the truth.


if i had a dollar for everytime someone says "merge" without using the word, i'd b so green i'd b King of Mars.
JAZZz50

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03/01/2024 05:32 PM

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SMAN, yesterday's TM news report was vax damages pituatary glans and others. kicked out trying to post 2 times yesterday.
JAZZZ50

2020 The SHTF literally as TP ran out.

we went from being over the target, to actually being the target. too close to the truth.


if i had a dollar for everytime someone says "merge" without using the word, i'd b so green i'd b King of Mars.
JAZZz50

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03/01/2024 05:44 PM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Angola: Luanda With Outbreak of Hemorrhagic Pink Eye

" health units have registered different types of pink eyes, with hemorrhagic being the most frequent, as IONA treats between 8 and 10 cases of this pathology daily. She highlighted that hemorrhagic pink eye has been expanding at great speed, and in some cases it is particularly serious. "



[link to rsoe-edis.org (secure)]
 Quoting: JAZZz50


Pink Eye outbreak: Malawi Health Ministry steps in with “No hand shake” order to contain spread

"over 800 cases reported across the country."


[link to rsoe-edis.org (secure)]


Brazil - Brazil surpasses 1 million probable cases of dengue this year

"214 confirmed deaths from the disease so far this year,
501 cases per 100,000 inhabitants,"

[link to rsoe-edis.org (secure)]
JAZZZ50

2020 The SHTF literally as TP ran out.

we went from being over the target, to actually being the target. too close to the truth.


if i had a dollar for everytime someone says "merge" without using the word, i'd b so green i'd b King of Mars.
JAZZz50

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03/01/2024 05:51 PM

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United States - 6th case of measles linked to Florida elementary school outbreak

"The first patient was a third-grade student without a history of travel.

."Measles was declared eliminated in the U.S. in 2000, meaning the disease "is no longer constantly present in this country."

The current two-dose measles, mumps and rubella (MMR) vaccine recommended by the Centers for Disease Control and Prevention is 93% effective after one dose and 97% effective after two doses.

.In Florida, at least 90.6% of kindergartners were fully vaccinated with the MMR vaccine for the 2022-23 school year,"

[link to rsoe-edis.org (secure)]

they blame ppl not getting vaccinated after the covid vax fiasco. however these children would have been vaccinated before 2020. this may well b the 1st outbreak in the US. let's see if this spreads like it has done overseas.
 Quoting: JAZZz50


this has hit MSM tonight. CDC claiming 23 cases across 11 states. 7 via international travel. these #'s are already outdated as i have seen news headlines that would add 2 more states.

[link to www.msn.com (secure)]
 Quoting: JAZZz50


UPDATE
FL now at 10 cases. 9 in 1 county. 7 students. 1 adult in another county.

So far, the U.S. has recorded 41 measles cases within the first two months of 2024, across 15 states.

[link to www.yahoo.com (secure)]
JAZZZ50

2020 The SHTF literally as TP ran out.

we went from being over the target, to actually being the target. too close to the truth.


if i had a dollar for everytime someone says "merge" without using the word, i'd b so green i'd b King of Mars.
ParamedicUK

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03/01/2024 05:55 PM

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SMAN, yesterday's TM news report was vax damages pituatary glans and others. kicked out trying to post 2 times yesterday.
 Quoting: JAZZz50


[link to www.thailandmedical.news (secure)]

Can’t cut and paste the web page though !

https://imgur.com/a/OmbYvqR


Last Edited by ParamedicUK on 03/01/2024 05:58 PM
Herd immunity and vaccine free is the only way……

Peace not War.
JAZZz50

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03/01/2024 06:12 PM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Measles Outbreak In Taiwan Sends Alarm Bells Ringing Across Asia

"The Centers for Disease Control (CDC) in Taiwan have identified a rare domestic measles cluster involving two individuals.

the index case, a man in his 30s,


The 306 close contacts include four non-cohabiting family members and 302 others whose activities overlapped with the infected medical worker.
Locations visited by the infected individual, such as the B2 food court in Terminal 2 of Taiwan Taoyuan International Airport and Liang's Rice Noodle Soup in New Taipei's Zhonghe District, have been identified as potential risk zones.


The most substantial surge has been reported in Europe
Europe recorded over 58,000 measles cases last year, a staggering 62 times the number reported in 2022"

[link to www.thailandmedical.news (secure)]
JAZZZ50

2020 The SHTF literally as TP ran out.

we went from being over the target, to actually being the target. too close to the truth.


if i had a dollar for everytime someone says "merge" without using the word, i'd b so green i'd b King of Mars.
JAZZz50

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03/01/2024 06:15 PM

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PARA, oddly not only did i get booted but the articles on TM disappeared. yesterday did not exist.... somebody made sure of it.
JAZZZ50

2020 The SHTF literally as TP ran out.

we went from being over the target, to actually being the target. too close to the truth.


if i had a dollar for everytime someone says "merge" without using the word, i'd b so green i'd b King of Mars.
ParamedicUK

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03/01/2024 06:25 PM

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PARA, oddly not only did i get booted but the articles on TM disappeared. yesterday did not exist.... somebody made sure of it.
 Quoting: JAZZz50


Weird
Herd immunity and vaccine free is the only way……

Peace not War.





GLP