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FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects

 
S-man

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01/13/2022 04:42 AM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Just putting this together - I believe this is VITALLY important!

Uncle Doom,

I was AMAZED - literally amazed when I ran the spike through the PLAAC and PAPA algos for prion-genic sites.

ALL the dangerous sites had been scrubbed from the spike.

On this front, what I am still concerned about is the Nucleocapsid which - when I looked at Wuhan-1 - still had a huge prion propensity.

Do you have any thoughts on the above?

Apart from this, the change to endosomal infection from ACE2/TMPRSS2 seems to be KEY to lowering pathogenicity in the lungs, and giving the body time to react properly in the upper-respiratory (tonsils?). If HCQ is an endosomal infection inhibitor (it is, afaik) then what about a re-evaluation of HCQ?

e.g.:
I think am on to something with the Glasgow Preprint.
[link to www.gla.ac.uk (secure)]

The lack of cell fusion as an entry mechanism by Omicron is documented in the preprint..Page 17:
Omicron spike has switched entry route preference
See Figure 6A.

The other known mechanism of entry (endocytosis) is shown to be used much better by Omicron. (aside: This explains the lower involvement of the lungs in Omicron infections..).

BUT most importantly, the endocytosis route has blockers that can be considered for use.. "Cathepsin blockers".

This paper is older; from when Sars-COV-2 was using the TMPRSS2+Furin Cleavage Site, as well as endocytosis.
[link to journals.plos.org (secure)]
Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection
Drugs targeting Cathepsin B/L are under development.
Hydroxychloroquine is thought to act against SARS-CoV-2 via several mechanisms, including blocking the endocytic pathway.; it suppresses clathrin-mediated virus uptake and also prevents endosomal acidification, the latter required for Cathepsin B/L activity.

[link to www.researchgate.net (secure)]
After one year of COVID-19 Pandemic and Hundreds of Suggested Drugs, Will Cathepsin L Inhibitors be the Solution?


Stock up on HCQ??
How crazy would it be to find that HCQ really is a solution to this part of the puzzle?
 Quoting: S-man

 Quoting: S-man 80505408



I missed the Cathepsin part completely; you are correct! In theory it could be used as a treatment.
 Quoting: d_senti



To recap: Omicron uses 'Route 2' endocytosis, NOT so much ACE2/TMPRSS2.
This means it is likely treatable with HCQ, Cathepsin-L inhibitors and such.


I also believe that Omicron will do less organ damage, Kidney, Heart, Brain/CNS/PNS, because it prefers 'Route 2' - not ACE2/TMPRSS2 entry. and on top of everything else, that 'Route 2' gives the body a warning period via the tonsils.

Last Edited by S-man on 01/13/2022 04:43 AM
Roughwildfly

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01/13/2022 05:17 AM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Another Covid Update

Family of four with Omicron

1 Vaccinated - scratchy throat, little tired and sore runny nostril from test.

3 Unvaccinated - Dry throat for a few mornings.

14 days since Positive test, did not disrupt anything in our lives accept paid leave.
And defiantly No long Covid symptoms for the time being.

Source 55 year old from work came back from 2 weeks of sick leave, said lied that she only had bronchitis.

Did not take any vitamins, supplements or medicine.

Back to life.
 Quoting: Anonymous Coward 81056983


I hope you dont. But my LC took 3 months to show an issue
I apologise for my spelling and grammar, Dyslexia is a biatch.

But add on MS and its a whole new world of magic spelling and rambling.

We all love green, thanks in advance :)

So thats how it is, deal with it or keep walking.

We all love green. Thanks in advance :)
lightning1977

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01/13/2022 05:32 AM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
UK's deputy chief medical office to leave role

Doommonkey

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01/13/2022 05:33 AM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
'Omicron appears, after close scrutiny in the field, to be the best, worst case offering* that could have been created and released (in such a short window of time that their team had to hand) in order to act as a firebreak that is easily spread through all forms of close contact*. I applaud the effort, as Omicron is eminently treatable at all stages, and if a public-wide usage of prophylaxis were put in place? We would see an ending to most, if not all, restrictions and deaths.'




* That the creator designed this without utilizing the ferociously malicious coding originally provided to academia and research, is to be congratulated.


** R0 of similar, if not higher, reach than classical Measels.


^^^^


Mrs Doom's email to one of the people who retain her services.



Omicron is engineered. itis a fire break.
The best that could be done in such
a short space of time whilstremaining hidden from official view.

A fire break whilst a better, sterilizing effort can be created and distributed.



Writing on the phone so not the best im afraid. Much love


Uncle Doom
 Quoting: Uncle Doom 81039128


I thought you were saying that this was the sneaky variant that went straight for the CNS and was causing horrible damage?

Have you changed your mind on that, or do you have new information?
Looks like freedom but it feels like death. It's something in between I guess... it's closing time.

Lenonard Cohen
Doommonkey

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01/13/2022 06:17 AM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
[link to www.theguardian.com (secure)]

My wife had long Covid and killed herself.
 Quoting: whitepiedtv


Most of the deaths from Lyme and ME/CFS are suicides. It's terribly difficult to live in a body that debilitated with no real solution in sight.
Looks like freedom but it feels like death. It's something in between I guess... it's closing time.

Lenonard Cohen
lightning1977

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01/13/2022 06:19 AM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
More scary looking videos from China



lightning1977

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01/13/2022 06:51 AM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Roughwildfly

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01/13/2022 06:55 AM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Maybe useful for sman

[link to www.ons.gov.uk (secure)]
I apologise for my spelling and grammar, Dyslexia is a biatch.

But add on MS and its a whole new world of magic spelling and rambling.

We all love green, thanks in advance :)

So thats how it is, deal with it or keep walking.

We all love green. Thanks in advance :)
whitepiedtv

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01/13/2022 07:06 AM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Possible Omicron with Stroke







S-man

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01/13/2022 07:39 AM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Maybe useful for sman

[link to www.ons.gov.uk (secure)]
 Quoting: Roughwildfly

Thanks, but Prof. Fenton has shown that the ONS have systematically mis-classified deaths by vax-status.. so our recourse now is to look at all-cause mortality alone.

Norman found some astonishing details - like:
"we have shown a range of fundamental inconsistencies and flaws in the data. Specifically.."
• In 2021 each age group has non-Covid mortality peaks for the unvaccinated at a different time, namely the time that vaccination rollout programmes for those cohorts reach a peak.
• The peaks in the Covid mortality data for the unvaccinated are inconsistent with the actual Covid wave.


[link to youtu.be (secure)]
5m20s:
"UNVAXXED SEEM TO BE DYING AFTER NOT GETTING 1ST DOSE & 1ST DOSED PEOPLE DYING AFTER NOT GETTING 2ND DOSE."
-simple explanation is simple mis-categorisation of "freshly-vaccinated" as "unvaccinated".

6m20s:
"UNVAXXED DYING OF COVID WHEN VAX ROLLS OUT"
hmm!

Report:
[link to www.researchgate.net (secure)]


Concise presentation by Prof. Fenton:
[link to rumble.com (secure)]

Last Edited by S-man on 01/13/2022 07:40 AM
Anonymous Coward
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01/13/2022 07:46 AM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects




Looks like a scene from I Am Legend


hidingburnitbump
S-man

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01/13/2022 08:05 AM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
OT:

What does one do about red karma obtained for simply enetering into a civil discussion with Cannabis Kills People?
Can it be got rid of? Requested from a mod?

I only use my karma to pin threads here when they are of real importance (like the USMC docs, or Paramedic's "infection rates among vaxxed" thread)..

Last Edited by S-man on 01/13/2022 08:06 AM
Anonymous Coward
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01/13/2022 08:23 AM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
OT:

What does one do about red karma obtained for simply enetering into a civil discussion with Cannabis Kills People?
Can it be got rid of? Requested from a mod?

I only use my karma to pin threads here when they are of real importance (like the USMC docs, or Paramedic's "infection rates among vaxxed" thread)..
 Quoting: S-man


What bad karma?

winkwhat
S-man

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01/13/2022 08:27 AM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Thread:

[link to godlikeproductions.com]
UPDATE: He Is RESIGNING!
-England's Deputy Chief Medical Officer AUTHORS paper on COVID Anti-Viral.. ....crickets! Where are the Journos?!

..the study, published in Viruses.
The chemical is Thapsigargin.
[link to pubmed.ncbi.nlm.nih.gov (secure)]

but here's the kicker:

authors:
Sarah Al-Beltagi 1 , Cristian Alexandru Preda 1 , Leah V Goulding 2 , Joe James 3 , Juan Pu 4 , Paul Skinner 3 , Zhimin Jiang 4 , Belinda Lei Wang 1 , Jiayun Yang 1 , Ashley C Banyard 3 , Kenneth H Mellits 5 , Pavel Gershkovich 6 , Christopher J Hayes 7 , Jonathan Nguyen-Van-Tam 8 , Ian H Brown 3 , Jinhua Liu 4 , Kin-Chow Chang 1

That name (Van-Tam) should be familiar to anyone in the UK.
He's one of the UK Government's "TV faces" of the pandemic!
He's the England's Deputy Chief Medical Officer.

Can ANY journalist worth their salt ask Van-Tam live on air what has happened to his broad-spectrum antiviral in the fight against COVID? The paper was published in February!

Are the UK Gov able to conduct and publicise research properly whilst contracting with Pfizer, AZ, Moderna etc.?
 Quoting: S-man


Looks like Van-Tam can't tolerate the Government's B.S. line of "vax-or-nothing" any more!

Last Edited by S-man on 01/13/2022 09:37 AM
S-man

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01/13/2022 08:31 AM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
OT:

What does one do about red karma obtained for simply enetering into a civil discussion with Cannabis Kills People?
Can it be got rid of? Requested from a mod?

I only use my karma to pin threads here when they are of real importance (like the USMC docs, or Paramedic's "infection rates among vaxxed" thread)..
 Quoting: S-man


What bad karma?

winkwhat
 Quoting: R. Wordsworth

Whoa... if that was you, you're a (*).
Beers are on me, If I can ever make it to New England.
Genetics
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01/13/2022 09:15 AM
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goodnews



Genetics Have Always Mattered and Are Everything With Covid


[link to www.yahoo.com (secure)]


Thu, January 13, 2022, 7:03 AM·1 min read
WARSAW (Reuters) - Polish scientists have found a gene that they say more than doubles the risk of becoming severely ill with COVID-19, a discovery they hope could help doctors identify people who are most at risk from the disease.


Other studies have also shown the importance of genetic factors in how seriously COVID-19 develops.

In November, British scientists said they had identified a version of a gene that may be associated with double the risk of lung failure from COVID-19.

Somebody was wrong again

.nutkick
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01/13/2022 09:34 AM
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I don’t see this being less organ damage. Just different and not immediately for all.
Roughwildfly

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01/13/2022 09:42 AM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
So if antibodies are high, but they need the 3rd dose, but antibodies play no part in infection control, how are the 3rd jabs protecting.

Does the body lose its b and t cells memory?

Anyone shed light on the mechanisms



I apologise for my spelling and grammar, Dyslexia is a biatch.

But add on MS and its a whole new world of magic spelling and rambling.

We all love green, thanks in advance :)

So thats how it is, deal with it or keep walking.

We all love green. Thanks in advance :)
Roughwildfly

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01/13/2022 09:44 AM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Is this them admitting that the vac does indeed kill some poor souls, but does stop a rush on the hospital, so i guess a win for the vac.


I apologise for my spelling and grammar, Dyslexia is a biatch.

But add on MS and its a whole new world of magic spelling and rambling.

We all love green, thanks in advance :)

So thats how it is, deal with it or keep walking.

We all love green. Thanks in advance :)
No one at all

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01/13/2022 09:45 AM
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Oops, sorry for using you and your wife as example, stay safe stay healthy, thanks.
 Quoting: whitepiedtv


Not a problem. That was the reason I posted our experience
Anonymous Coward
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01/13/2022 09:52 AM
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Oh my fucking hell. The WHO still thinks this has an ending and refuses to call it endemic.

It’s here. It’s. Fucked. How can this idiot keep a straight face? He knows what we know.

[link to twitter.com (secure)]


 Quoting: CleverCreator
S-man

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01/13/2022 10:17 AM

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Is this them admitting that the vac does indeed kill some poor souls, but does stop a rush on the hospital, so i guess a win for the vac.


 Quoting: Roughwildfly


Fascinating stuff..reading..
My take: he's shown that the ONS' explanation is BS, and they owe us answers about the spikes in unvaxxed non-covid deaths as the vax rolls out..

Here is a threadreaderapp of Martin Neil's analysis (He works with Norman Fenton afaik).
[link to threadreaderapp.com (secure)]

-Archive it, cos we konw they disappear when the twatter account gets nuked!
LJSModerator
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01/13/2022 10:21 AM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
goodnews



Genetics Have Always Mattered and Are Everything With Covid


[link to www.yahoo.com (secure)]


Thu, January 13, 2022, 7:03 AM·1 min read
WARSAW (Reuters) - Polish scientists have found a gene that they say more than doubles the risk of becoming severely ill with COVID-19, a discovery they hope could help doctors identify people who are most at risk from the disease.


Other studies have also shown the importance of genetic factors in how seriously COVID-19 develops.

In November, British scientists said they had identified a version of a gene that may be associated with double the risk of lung failure from COVID-19.

Somebody was wrong again

.nutkick
 Quoting: Genetics 81848395


So, it was engineered to target certain genetics.

Color me shocked.
Fate whispers to the warrior

"You cannot withstand the storm"

the warrior whispers back

"I am the storm"

INTJ-A

Killer Bunny
S-man

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01/13/2022 10:25 AM

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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
So if antibodies are high, but they need the 3rd dose, but antibodies play no part in infection control, how are the 3rd jabs protecting.

Does the body lose its b and t cells memory?

Anyone shed light on the mechanisms



 Quoting: Roughwildfly


The AB's produced in people naturally infected react with *all* the proteins in the virus to some extent, but the vaccines produce only anti-Spike ABs. Those are not neutralising any more, as they are out-of date for the cirulating virus (Omicron).
-There are Antibodies, and there are Antibodies.

Also, the vaccines themselves diminish the Adaptive Immune system by impairing DNA damage repair (double-strand breaks, see below..)

I saw Dr Been describe this DNA-mending impairment as causing the b and t-cells to have less variability; less able to cope with variants. [link to www.youtube.com (secure)] (intro 3 mins onwards, meat starts at 6m50s, t,b-cells/proliferation at 13m, b,t-cell variability 14m, DNA-repair effect on t,b-cells 19m)

[link to www.mdpi.com (secure)]
SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro

"we report that the SARS–CoV–2 spike protein significantly inhibits DNA damage repair, which is required for effective V(D)J recombination in adaptive immunity. Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. Our findings reveal a potential molecular mechanism by which the spike protein might impede adaptive immunity and underscore the potential side effects of full-length spike-based vaccines"

Last Edited by S-man on 01/13/2022 10:57 AM
Lago

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01/13/2022 10:27 AM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
Coronavirus India Live Updates: India Records 2,47,417 New Covid Cases, 27% Higher Than Yesterday (Jan 12 --442,137)... [link to www.ndtv.com (secure)]


Remember this?
Uttar Pradesh government says early use of Ivermectin helped to keep positivity, deaths low .. [link to www.msn.com (secure)]

In Uttar Pradesh, active cases climb to 57,355; positivity rate 5.70%. ... [link to indianexpress.com (secure)]

Last Edited by Lago on 01/13/2022 02:12 PM
Lago
S-man

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01/13/2022 10:34 AM

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Coronavirus India Live Updates: India Records 2,47,417 New Covid Cases, 27% Higher Than Yesterday ... [link to www.ndtv.com (secure)]


Remember this?
Uttar Pradesh government says early use of Ivermectin helped to keep positivity, deaths low .. [link to www.msn.com (secure)]

In Uttar Pradesh, active cases climb to 57,355; positivity rate 5.70%. ... [link to indianexpress.com (secure)]
 Quoting: Lago

They arent using it atm?
They know how to control it, but they might decide not to bother, if it is not that serious.

Last Edited by S-man on 01/13/2022 10:35 AM
Lago

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01/13/2022 10:43 AM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
SC, i woulda took a bleach bath and misted my nose and mouth with bleach steam. wouldn't been the 1st time either. when i had to go to the ER, i damn near jumped in with my clothes. plus went to horsey for few days.
 Quoting: JAZZz50


When you say a "bleach bath" and "bleach steam" what % of bleach are you putting in the water and what type of bleach are you using Jazz?
Lago
Lago

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01/13/2022 10:48 AM
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SC, i woulda took a bleach bath and misted my nose and mouth with bleach steam. wouldn't been the 1st time either. when i had to go to the ER, i damn near jumped in with my clothes. plus went to horsey for few days.
 Quoting: JAZZz50


I did a Neti Pot as SOON as I got home! Forgot to add that in
 Quoting: SpinalCracker

Nasal Irrigation to Reduce COVID-19 Morbidity.. [link to clinicaltrials.gov (secure)]

Interesting...
Lago
Lago

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01/13/2022 10:51 AM
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Coronavirus India Live Updates: India Records 2,47,417 New Covid Cases, 27% Higher Than Yesterday ... [link to www.ndtv.com (secure)]


Remember this?
Uttar Pradesh government says early use of Ivermectin helped to keep positivity, deaths low .. [link to www.msn.com (secure)]

In Uttar Pradesh, active cases climb to 57,355; positivity rate 5.70%. ... [link to indianexpress.com (secure)]
 Quoting: Lago

They arent using it atm?
They know how to control it, but they might decide not to bother, if it is not that serious.
 Quoting: S-man

That is a pretty thin assumption given that Covid is probably all around them (probably 10 times official number), and that older members of their family are probably really suffering. Also, officially, the Omicron variant is only justing starting..."The country witnessed 620 new Omicron cases". ????.... [link to www.financialexpress.com (secure)]

Last Edited by Lago on 01/13/2022 10:59 AM
Lago
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01/13/2022 10:58 AM
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Re: FOR CORONACOASTER: COVID-19 News, Info, Discussion /// Tracking the Spread of the Virus and its Effects
goodnews



Genetics Have Always Mattered and Are Everything With Covid


[link to www.yahoo.com (secure)]


Thu, January 13, 2022, 7:03 AM·1 min read
WARSAW (Reuters) - Polish scientists have found a gene that they say more than doubles the risk of becoming severely ill with COVID-19, a discovery they hope could help doctors identify people who are most at risk from the disease.


Other studies have also shown the importance of genetic factors in how seriously COVID-19 develops.

In November, British scientists said they had identified a version of a gene that may be associated with double the risk of lung failure from COVID-19.

Somebody was wrong again

.nutkick
 Quoting: Genetics 81848395


So, it was engineered to target certain genetics.

Color me shocked.
 Quoting: LJS


Yeah, but what troll fan is trying to say is its family is untouchable.

And that is wrong. This was NOT a completed project. My theory still stands - up front it looks like it works, but over time and multiple infections this genetics thing won’t hold water because it will cause damage over and over again.

He just hates where the information came from. And it is not telling the truth about its history. Because it needs to be anti-Semitic.





GLP