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'Dark matter' of human genome finally decoded, sequencing entirety of human DNA

 
TheWorldsEnemy
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'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
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Scientists say they have finally assembled the full genetic blueprint for human life, adding the missing pieces to a puzzle nearly completed two decades ago.

An international team described the first-ever sequencing of a complete human genome – the set of instructions to build and sustain a human being – in research published Thursday in the journal Science. The previous effort, celebrated across the world, was incomplete because DNA sequencing technologies of the day weren't able to read certain parts of it. Even after updates, it was missing about 8% of the genome.

“Some of the genes that make us uniquely human were actually in this ‘dark matter of the genome’ and they were totally missed,” said Evan Eichler, a University of Washington researcher who participated in the current effort and the original Human Genome Project. “It took 20-plus years, but we finally got it done.”

Many — including Eichler's own students — thought it had been finished already. “I was teaching them, and they said, 'Wait a minute. Isn’t this like the sixth time you guys have declared victory? I said, ’No, this time we really, really did it!”

Scientists said this full picture of the genome will give humanity a greater understanding of our evolution and biology while also opening the door to medical discoveries in areas like aging, neurodegenerative conditions, cancer and heart disease.

“We’re just broadening our opportunities to understand human disease,” said Karen Miga, an author of one of the six studies published Thursday.

The research caps off decades of work. The first draft of the human genome was announced in a White House ceremony in 2000 by leaders of two competing entities: an international publicly funded project led by an agency of the U.S. National Institutes of Health and a private company, Maryland-based Celera Genomics.

The human genome is made up of about 3.1 billion DNA subunits, pairs of chemical bases known by the letters A, C, G and T. Genes are strings of these lettered pairs that contain instructions for making proteins, the building blocks of life. Humans have about 30,000 genes, organized in 23 groups called chromosomes that are found in the nucleus of every cell.

Before now, there were "large and persistent gaps that have been in our map, and these gaps fall in pretty important regions,” Miga said.

Miga, a genomics researcher at the University of California-Santa Cruz, worked with Adam Phillippy of the National Human Genome Research Institute to organize the team of scientists to start from scratch with a new genome with the aim of sequencing all of it, including previously missing pieces. The group, named after the sections at the very ends of chromosomes, called telomeres, is known as the Telomere-to-Telomere, or T2T, consortium.

Their work adds new genetic information to the human genome, corrects previous errors and reveals long stretches of DNA known to play important roles in both evolution and disease. A version of the research was published last year before being reviewed by scientific peers.

“This is a major improvement, I would say, of the Human Genome Project,” doubling its impact, said geneticist Ting Wang of the Washington University School of Medicine in St. Louis, who was not involved in the research.

Eichler said some scientists used to think unknown areas contained “junk." Not him. "Some of us always believed there was gold in those hills," he said. Eichler is paid by the Howard Hughes Medical Institute, which also supports


... more at link

Last Edited by LJS on 03/31/2022 05:59 PM
chulahoma

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03/31/2022 06:06 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
Can't say I have a good feeling about this.
Anonymous Coward
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03/31/2022 06:07 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
THANK GOD IT ISN'T TRUE.
Anonymous Coward
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03/31/2022 06:08 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
Can't say I have a good feeling about this.
 Quoting: chulahoma


hesright
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03/31/2022 06:09 PM

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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
You know, call me a disenchanted cynic but I feel this is a dark day for humanity.

The wrong people are probably behind this.
"She isn't real.....I can't make her real"

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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
Can't say I have a good feeling about this.
 Quoting: chulahoma



I share your sentiment compadre.

Last Edited by Just Passing Through..... on 03/31/2022 06:10 PM
"She isn't real.....I can't make her real"

"Somewhere between the sacred silence and sleep...Disorder, Disorder, Disorder"

"The World is a business Mr Beale..."

"You depend on our protection yet you feed us lies from the tablecloth......"

ENFJ
Jules Red

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03/31/2022 06:14 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
Can't say I have a good feeling about this.
 Quoting: chulahoma


Yep same here.
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Marvelous Man

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03/31/2022 06:18 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
It will prove that intelligent design is superior to Darwinian evolution theory.
There are two ways to be fooled. One is to believe what isn’t true; the other is to refuse to believe what is true.
Anonymous Coward
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03/31/2022 06:22 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
They can't copy my blood though 0-
LucyLucid

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03/31/2022 06:25 PM

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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
Someone is about to step up their clone game.
Anonymous Coward
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03/31/2022 06:31 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
Turns out that gold includes many important genes, he said, such as ones integral to making a person's brain bigger than a chimp's, with more neurons and connections.
The Alkahest

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03/31/2022 07:22 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
They can't copy my blood though 0-
 Quoting: Anonymous Coward 82589288


Wait, is there something proven and unique about us O negative types? Can you point me to actual data? It would be a small comfort to know that I'm the only member of my nuclear family that happens to be unclonable, lol.
The Alkahest

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The Alkahest

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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
Turns out that gold includes many important genes, he said, such as ones integral to making a person's brain bigger than a chimp's, with more neurons and connections.
 Quoting: Anonymous Coward 78937683


Are you saying that metallic gold facilitates the expression of neural development genes, or are you referring to something else?
The Alkahest

A Meta-sapient Godelian Recursion Engine. Super Fun at Parties.
Researching human evolution via Fractal Psychogenic Ontology. Disclaimer: Current project (un?)constrained by sample-size N=1
Anonymous Coward
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03/31/2022 07:30 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
Give me more funding!
Anonymous Coward
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03/31/2022 07:32 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
But still no cute for cancer or diabetes?
Base12

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03/31/2022 07:33 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
Turns out that gold includes many important genes, he said, such as ones integral to making a person's brain bigger than a chimp's, with more neurons and connections.
 Quoting: Anonymous Coward 78937683


Are you saying that metallic gold facilitates the expression of neural development genes, or are you referring to something else?
 Quoting: The Alkahest

No. It is a figure of speech the article used.

I almost thought this was Fake News.
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WiscoSteve
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
Evan Eichler


Nothing to see here....




.
Anonymous Coward
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03/31/2022 07:34 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
Visit a underground cloning factory... the have it for decades
PSA

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03/31/2022 07:38 PM

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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
Visit a underground cloning factory... the have it for decades
 Quoting: Anonymous Coward 79408105


Have you?
"The truth is incontrovertible. Malice may attack it, ignorance may deride it, but in the end, there it is." Winston Churchill

Thread: THE NANO/AI/FREQUENCY/BCI MIND CONTROL SYSTEM

Thread: Humans are now "hackable animals"?

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Anonymous Coward
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03/31/2022 07:39 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
which gene is penis length and breadth?
Justice4all

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03/31/2022 07:48 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
Yes this makes me very uneasy...this is getting into the place where man thinks he can play God.
Anonymous Coward
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03/31/2022 08:14 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
Yes this makes me very uneasy...this is getting into the place where man thinks he can play God.
 Quoting: Justice4all


If you look into John Craig Venter, they already have. He was the first to claim the full mapping of the human genome and has been playing with synthetic life for a long time. He created a synthetic bacteria to clean up the oil in the 2010 gulf of Mexico disaster. Apparently it mutated and is still on the loose. Plenty of information out there for those who like to stay well informed.
Anonymous Coward
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
“This is a major improvement, I would say, of the Human Genome Project,” doubling its impact, said geneticist Ting Wang of the Washington University School of Medicine in St. Louis, who was not involved in the research

Meanwhile, Yu Wang is still collecting royalties from reruns of the Addams Family. lolsign
The Alkahest

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03/31/2022 08:17 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
which gene is penis length and breadth?
 Quoting: Anonymous Coward 82666773


That's actually more contingent on the level of exposure to testosterone in the womb. If your mother had high testosterone, your penis will be larger on average. It affects women too, causing a condition called "clitoromegaly" - a oversized clitoris. The penis is actually a clitoris that develops differently due to the Y chromosome, so both organs come from the same tissue.
The Alkahest

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Researching human evolution via Fractal Psychogenic Ontology. Disclaimer: Current project (un?)constrained by sample-size N=1
Anonymous Coward
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03/31/2022 08:24 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
But still no cute for cancer or diabetes?
 Quoting: Anonymous Coward 69408373


Almost as if someone is trying to keep us sick...
Anonymous Coward
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03/31/2022 08:37 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
Turns out that gold includes many important genes, he said, such as ones integral to making a person's brain bigger than a chimp's, with more neurons and connections.
 Quoting: Anonymous Coward 78937683


Are you saying that metallic gold facilitates the expression of neural development genes, or are you referring to something else?
 Quoting: The Alkahest


there are legends where Gods ate gold to grow stronger...

something to think about
SomeRandomPerson

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03/31/2022 08:41 PM

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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
It will prove that intelligent design is superior to Darwinian evolution theory.
 Quoting: Marvelous Man


No it won't. Not at all. It will prove the opposite. Hide and watch.
I believe in science NOT religion. Giving me bad karma for that, is anti-religious (you're passing judgement) I am just a man. Of no significance. Who found religion to be full of lies, and wrong doing, conflicted teachings
I understand microwave communications.
I do not stand for the NWO, it sucks.
The Alkahest

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03/31/2022 08:42 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
But still no cute for cancer or diabetes?
 Quoting: Anonymous Coward 69408373


Almost as if someone is trying to keep us sick...
 Quoting: Anonymous Coward 82121352


As hard as this might be to believe, I've actually developed a treatment that caused remission and an 80% tumor mass reduction in a stage 4 small-cell lunge cancer patient. I did this with nothing more than dietary sugar restrictions, alkaline nebulizer solutions (aqueous bicarbonate), and immune stimulation via herbal-derived caspase-signaling enzyme stimulation. This was largely based on research and theories by many other scientists, I just put it together using my understanding of how it works. I think I'll make a thread about this protocol and share it here.

It is utterly frightening how easy it is to treat cancer. There is no excuse for the modern medical establishment with doctors FAR more intelligent than myself to have missed this for so long. You need to enhance the immune system of the patient, not cripple it with chemo.

Disclaimer - not intended as official medical advice for the treatment of any illness.
The Alkahest

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Researching human evolution via Fractal Psychogenic Ontology. Disclaimer: Current project (un?)constrained by sample-size N=1
SomeRandomPerson

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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
Visit a underground cloning factory... the have it for decades
 Quoting: Anonymous Coward 79408105


Have you?
 Quoting: PSA


Of course not, he's just making it up.
I believe in science NOT religion. Giving me bad karma for that, is anti-religious (you're passing judgement) I am just a man. Of no significance. Who found religion to be full of lies, and wrong doing, conflicted teachings
I understand microwave communications.
I do not stand for the NWO, it sucks.
letitbe

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03/31/2022 08:47 PM

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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
Makes me think of the tower of Babylon. Humanity’s ability and propensity to cross boundaries and of God’s endeavor to check such behavior. He just dispersed the people then. He warned us.
letitnotbe because be it let be or not does not make sense.
The Alkahest

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03/31/2022 08:51 PM
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Re: 'Dark matter' of human genome finally decoded, sequencing entirety of human DNA
Turns out that gold includes many important genes, he said, such as ones integral to making a person's brain bigger than a chimp's, with more neurons and connections.
 Quoting: Anonymous Coward 78937683


Are you saying that metallic gold facilitates the expression of neural development genes, or are you referring to something else?
 Quoting: The Alkahest


there are legends where Gods ate gold to grow stronger...

something to think about
 Quoting: Anonymous Coward 82079276


I took a regimen of gold nanoparticles for a couple months just to see if it lived up to the hype. It caused some very strange psychological effects and eventually a full-blown hallucination. This is not an effect I've seen documented anywhere else on the internet. On the bright side, it significantly reduced the intensity of my chronic inflammatory condition in my gut and my joints, which is a well-accepted effect of this treatment.
The Alkahest

A Meta-sapient Godelian Recursion Engine. Super Fun at Parties.
Researching human evolution via Fractal Psychogenic Ontology. Disclaimer: Current project (un?)constrained by sample-size N=1





GLP