from 2022: ALERT!! Moderna, Merck announce cancer vaccines.... using MRNA!! and also for FLU vaccines! and GENE EDITING!!!

January 20, 2022:


A technician in full body protective gear adjusting a machine for making mRNA vaccines.

The coronavirus pandemic has thrown a spotlight on messenger RNA (mRNA)—the molecule that carries a cell’s instructions for making proteins. Hundreds of millions of people worldwide have received mRNA vaccines that provide powerful protection against severe COVID-19 caused by infection with SARS-CoV-2.

As stunningly successful as the mRNA COVID-19 vaccines have been, researchers have long hoped to use mRNA vaccines for a very different purpose—to treat cancer. mRNA-based cancer treatment vaccines have been tested in small trials for nearly a decade, with some promising early results.

In fact, scientists at both Pfizer-BioNTech and Moderna drew on their experience developing mRNA cancer vaccines to create their coronavirus vaccines. Now, some investigators believe the success of the mRNA COVID-19 vaccines could help accelerate clinical research on mRNA vaccines to treat cancer.

“There’s a lot of enthusiasm around mRNA right now,” said Patrick Ott, M.D., Ph.D., who directs the Center for Personal Cancer Vaccines at the Dana-Farber Cancer Institute. “The funding and resources that are flowing into mRNA vaccine research will help the cancer vaccine field.”

[link to www.cancer.gov (secure)]

Last Edited by Digital mix guy Spock on 12/14/2022 10:02 AM

Q !!Hs1Jq13jV6 ID: 000000 No.17830326 📁
Nov 27 2022 20:06:20 (EST)
What is coded in your DNA?
Who put it there?
Why?
Mankind is repressed.
We will be repressed no more.
Information is knowledge.
Knowledge is power.
Information is power.
How do you protect your DNA?
There is a war for your DNA.
Protect your DNA.
Ascension.
Q

Moderna says personalized mRNA cancer vaccine is effective for advanced melanoma

The company said that in a phase 2 clinical trial, the vaccine, when combined with immunotherapy drug Keytruda, reduced the risk of recurrence by 44%.

Moderna’s stock soared Tuesday after the Covid-19 vaccine maker detailed progress in developing a preventive shot for a deadly form of skin cancer.

The company said a possible melanoma vaccine it is studying with pharmaceutical giant Merck fared well in a small study of patients who had the cancer surgically removed.

The drugmakers said a combination of the vaccine and Merck’s immunotherapy Keytruda led to a statistically significant improvement in survival before the cancer returned in patients with advanced melanoma.

“We are very excited, we are moving very quickly with Merck onto phase 3 for this study,” Moderna CEO Stephane Bancel told CNBC Tuesday morning.

Phase 3 is generally the largest and most expensive stage of clinical research before regulators review a potential drug for approval.

Moderna developed one of the most popular vaccines used to protect patients against Covid, and the drugmaker brought in more than $3 billion from its Spikevax in this year’s third quarter.



[link to www.nbcnews.com (secure)]

Moderna, Inc. (NASDAQ:MRNA), a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, and Merck (NYSE:MRK), known as MSD outside of the United States and Canada, today announced that the Phase 2b KEYNOTE-942/mRNA-4157-P201 trial of mRNA-4157/V940, an investigational personalized mRNA cancer vaccine, in combination with KEYTRUDA®, Merck's anti-PD-1 therapy, demonstrated a statistically significant and clinically meaningful improvement in the primary endpoint of recurrence-free survival (RFS) versus KEYTRUDA alone for the adjuvant treatment of patients with stage III/IV melanoma following complete resection. Adjuvant treatment with mRNA-4157/V940 in combination with KEYTRUDA reduced the risk of recurrence or death by 44% (HR=0.56 [95% CI, 0.31-1.08]; one-sided p-value=0.0266) compared with KEYTRUDA alone.

"Today's results are highly encouraging for the field of cancer treatment. mRNA has been transformative for COVID-19, and now, for the first time ever, we have demonstrated the potential for mRNA to have an impact on outcomes in a randomized clinical trial in melanoma," said Stéphane Bancel, Moderna's Chief Executive Officer. "We will begin additional studies in melanoma and other forms of cancer with the goal of bringing truly individualized cancer treatments to patients. We look forward to publishing the full data set and sharing the results at an upcoming oncology medical conference, as well as with health authorities."

"These positive findings represent an important milestone in our collaboration with Moderna," said Dr. Dean Y. Li, president, Merck Research Laboratories. "Over the last six years, our teams have worked closely together combining our respective expertise in mRNA and immuno-oncology with a focus on improving outcomes for patients with cancer. We look forward to advancing this program into the next phase of development."

"The results of this randomized Phase 2b trial are exciting for the field. These data provide the first evidence that we can improve on the rates of recurrence-free survival achieved by PD-1 blockade in resected high-risk melanoma. These findings also provide the first randomized evidence that a personalized neoantigen approach may be beneficial in melanoma," said Jeffrey S. Weber, MD, PhD, principal investigator of the study and Deputy Director of the Perlmutter Cancer Center at NYU Langone. Dr. Weber is a paid consultant for Merck and Moderna.




[link to investors.modernatx.com (secure)]

It doesn't keep you from getting cancer or dying from cancer, but imagine how bad it would be if dead cancer patients didn't get it

How mRNA Vaccines Help Fight Cancer Tumors, Too
June 15, 2021

Thanks to researchers in different fields who put in nearly two decades of past work on mRNA vaccine technology, people around the world are being immunized today from COVID-19 — and hopefully leading us out of this pandemic. Now, because of the increased focus on this versatile technology and that foundation of research, mRNA vaccines for other diseases have an even greater chance of making it to patients.

“The whole platform is very, very flexible,” said Norbert Pardi, PhD, a research assistant professor of Infectious Diseases in the Perelman School of Medicine. “You can use mRNA vaccines for many things.”

That includes cancer — which is just one of several areas outside of infectious diseases that researchers at Penn have been investigating.

Here’s a breakdown of how an mRNA-based vaccine could work to fight tumors, the challenges that need to be overcome, the technology’s roots in oncology, and where it’s headed.

Protection vs. Attack

There’s a key difference between how a vaccine would be used to treat cancers versus a vaccine that’s used for an infectious disease like COVID-19.

First, the mRNA vaccines for COVID-19 protect people from the virus. They’re prophylactic. But a cancer mRNA vaccine is an intervention (a treatment) given to patients with the hope that their immune systems would be activated in a way that would attack tumor cells.

Through their research, Pardi and others, including researchers whose work led to the development of the BioNTech and Moderna vaccines, Drew Weissman, MD, PhD, a professor of Infectious Diseases in the Perelman School of Medicine, and Katalin Karikó, PhD, an adjunct associate professor at Penn and a senior vice president at BioNTech, found that mRNA vaccines can not only prompt strong antibody responses to fight off invaders, like COVID-19, but also potent cytotoxic T cell responses.

That’s important because these T cells can kill cancer cells. They just need to be altered or motivated to do it. Think immunotherapy, like checkpoint inhibitors or chimeric antigen receptor (CAR) T cell therapy that engineers a patient’s own T cells to find and destroy cancer cells.

“A successful therapeutic cancer vaccine should induce strong T cell responses, particularly with CD8+ T cells, which have a known capacity to kill malignant cells,” said Pardi, who is currently leading studies to better understand mRNA vaccines to treat cancers, along with other diseases. Pardi was also a postdoctoral researcher in Weissman’s lab and a frequent collaborator with him and Karikó. “Therapeutic cancer vaccines would be given to cancer patients with the hope that those vaccine-induced cytotoxic T cells would clear tumor cells.”





[link to www.pennmedicine.org (secure)]

"At Penn Medicine, we are proud to pursue bold, paradigm-changing strategies to improve health and treat and cure disease – this ethos is a common trait among our faculty, staff, and students, and it is brought to life in the most inspiring ways,” said J. Larry Jameson, MD, PhD, executive vice president of the University of Pennsylvania for the Health System and dean of the Perelman School of Medicine.

Building an Interception Toolkit

Everyone has BRCA1 and BRCA2 genes, but some people are born with an error, or mutation, in one of these genes. Men and women with either of these inherited gene mutations are at increased risk for certain cancers, including breast, ovarian, prostate, and pancreatic cancers. Today, options for prevention of BRCA-related cancers are largely limited to surgical options such as the removal of healthy breasts and ovaries, both of which can bring significant side effects and tradeoffs. Other patients typically undergo close monitoring, but there are currently no reliable early detection methods for ovarian and pancreatic cancer.

The goal of interception, Domchek says, is to identify and deploy a toolkit of strategies that can be used much like HPV testing for cervical cancer screening and colonoscopies for colon cancer – both tests allow identification of pre-cancerous cells and opportunities to intervene before they develop into disease.

An interception plan for BRCA mutation carriers could potentially include a series of timed interventions designed to keep cancerous cells at bay. In the case of a 25-year-old woman who learns she has a BRCA mutation, for example, future initial care might include close monitoring – with, for instance, “liquid biopsies” – to detect even the most minute amounts of abnormal cells that are on the path to becoming cancer. At age 40, as the risk of cancer increases, her care team could administer a cancer vaccine, “setting back” the biological clock and stopping the growth of precancerous cells. At age 55, doctors could again intercept, perhaps with a drug from the class known as PARP inhibitors, which are already approved for both treatment and recurrence prevention of BRCA-related cancers. At age 70, another interception might be administered, such as preventive radiation or immunotherapy.

[link to www.pennmedicine.org (secure)]

Last Edited by Digital mix guy Spock on 12/14/2022 09:44 AM

Nov. 21, 2022: mRNA revolutionized the race for a Covid-19 vaccine. Could cancer be next?

The unprecedented success of messenger RNA vaccines against the coronavirus is raising hopes that the technology could lead to new and better vaccines against a much older public health scourge: cancer.

In some ways, the challenge is similar: The aim of any vaccine is to focus the immune system’s response against a particular molecule, or antigen, whether that’s a piece of a virus or a protein that coats tumor cells. There’s one important difference, however: Cancer vaccines are generally treatments rather than preventative measures.

“The tumor cells are already there. And you have to build an army of immune cells which is big enough,” said Özlem Türeci, co-founder and chief medical officer of BioNTech, which has eight different cancer vaccines currently in clinical trials. “It’s a numbers game to conquer a tumor, which means you have to be able to induce very strong immune responses.”

Biotech companies are approaching this problem in two main ways: targeting antigens that are shared across patients and going after tailor-made targets. The former are “off-the-shelf” vaccines that could be used across patients, while the latter are bespoke vaccines.


The personalized approach starts by taking a sample of both a patient’s cancer cells and healthy tissue. Researchers then compare the DNA and RNA sequences of these healthy and cancerous samples to identify mutations they can target with a vaccine.

RELATED: The future of messenger RNA: Covid-19 vaccines are just the beginning

There are plenty of examples now in process, including a Phase 2 trial BioNTech started in October 2021 for colon cancer patients who’ve had their tumors surgically removed but still have cancer cells remaining, with bits of tumor DNA floating in their blood. The roughly 200-person randomized study is testing whether the vaccine improves disease-free survival compared with simply monitoring patients, which is the current standard.





[link to www.statnews.com (secure)]

The future of messenger RNA: Covid vaccines were just the beginning

pRICE FOR REPORT: $499.00

Messenger RNA, the same genetic material that pharmaceutical companies quickly harnessed to develop game-changing Covid-19 vaccines, is opening up a world of possibilities, and arming doctors with new tools to prevent or combat disease.

In this report, STAT, the most authoritative source for reporting on innovations in health care and biotech, delves into the potential of mRNA. In it, you will:

Find out which 10 companies are at the forefront of mRNA research.
Have enough background to understand just how transformative mRNA is likely to be.
And get a sense of how mRNA is powering the next generation of gene-editing technologies, opening the door to new drugs and novel cancer treatments.


[link to reports.statnews.com (secure)]

cORPORATE WEBSITE:


mRNA Therapeutics (mRNA)
We use multiple mRNA formats with distinct properties to develop a new class of versatile, tailored therapeutics with the potential to address a wide variety of diseases with high unmet medical needs.

[link to www.biontech.com (secure)]

Thread: 2023 could be an IMPORTANT year!!! keep a watch on the MIDEAST region!!!

no one dies of flu = emergency use authorization approved vaccine..

lots of people dying of cancer = no emergency use authorization.

odd world.

Humanity is now officially fucked. These Medical tyrants will start injecting endless mRNA poisons by the tens of billions under the guise of preventing every disease known to man. Of course, with as little "mouse" testing as possible and no human testing. And the Sheep will line up like crazy to get their mRNA addiction satisfied. Since the mRNA "vaccination" will only last a few months, everyone will need an endless stream of Vaxxes and a Vaccine Passport and Digital ID to keep track of things.

From Elon Musk!!


Tesla Inc Chief Executive Officer Elon Musk on July 2 announced on the microblogging site Twitter that the electric carmaker is building "RNA microfactories" for coronavirus vaccine developer CureVac in Germany.

CureVac, an unlisted German company, has said it is developing transportable, automated mRNA production units that it calls printers. They will be designed to be shipped to remote locations, where they can churn out its vaccine candidate and other mRNA-based therapies depending on the recipe fed into the machine.

But for the immediate pandemic use - should its vaccine candidate win market approval - it has production sites with regulatory approval in Germany with a capacity to produce hundreds of millions of doses.



[link to www.moneycontrol.com (secure)]



Last Edited by Digital mix guy Spock on 12/14/2022 03:12 PM

Juan star!

KILLING YOU IN THE NAME OF MEDICINE IS BEAUCOUP $$$$$$ $$$$$$ $$$$$$

hey, thanks for the pin, GLP! and please be sure to visit my home HQ thread, below! we post lots of items and info there as well!




Thread: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine

It's pure ploy.

Opinion: Thought mRNA vaccines would end with the pandemic? Think again

Mon December 12, 2022

The easing of China’s policy may be heralded as a victory, but it’s one that could come with a steep cost. As of late November, 90% of China’s population had completed two doses of a Covid-19 vaccine, while only about 66% of people over 80 had received two doses, according to Chinese officials. What’s more, the vaccines available to Chinese citizens use an inactivated SARS-CoV-2 virus, and pale in comparison to their mRNA counterparts that are approved in the US, says Weissman.

But now, it seems, China is recognizing the promise of mRNA vaccines; it’s reportedly close to having one, made in its own country, approved for use. If that approval comes soon, it could deliver the nation from its pandemic turmoil.

This interview has been edited for length and clarity:

CNN: Can you explain how an mRNA vaccine works? What happens in the body after someone gets an mRNA shot?

Weissman: In an mRNA vaccine, the mRNA acts as a kind of middleman. In our cells, DNA contains all the codes for the proteins we need to live. The messenger RNA makes a copy of one of those codes and brings it to a machine called a ribosome that reads the mRNA code and produces a protein from it.

An mRNA Covid-19 vaccine supplies the codes for part of the SARS-CoV-2 virus called the spike protein. The ribosomes read the mRNA vaccine code and create the virus’ spike protein from it — and the body’s immune system starts recognizing it and creating antibodies to respond to it. Then, if the real virus is ever introduced into the system, the body will recognize its spike protein and will have already built up the antibodies needed to fight it off.

CNN: What were the biggest challenges to developing the mRNA vaccine platform?

Weissman: The roadblocks started 25 years before the pandemic hit. Back then, everybody took the attitude that mRNA wasn’t a good therapeutic and that it was a waste of resources to do the research. Support and funding were the biggest roadblocks we hit. We finally got funding, but even after that, it was years before people started to think, “Oh, wait a minute, RNA might actually be useful!”

CNN: When the scientific community was skeptical of investing in RNA research, what was it that kept you from giving up on it?

Weissman: The reason I kept at it was the potential I thought RNA had. When you have to make a new vaccine for a new disease using live viruses, it’s a huge amount of work. But RNA is simple. It’s plug and play. You take any protein you want to make an immune response against, you make RNA from it, you stick it in lipids, and you’re done. It was a simple platform that could be used emergently if a new virus suddenly appeared. We were thinking that it would be used against a flu pandemic, but when Covid hit, the vaccine was ready to go.

I also thought that in addition to vaccines, we might be able to deliver therapeutic proteins and gene edit with RNA. There was so much potential that we felt that the drawbacks needed to be addressed and figured out. And that’s why we stuck with it for so many years.

CNN: Do you see a future in which we turn to RNA therapeutics to treat or prevent things like the flu, cancers or autoimmune diseases?

Weissman: We’re now turning to RNA for more than just vaccines. There are therapeutics in the works for a variety of diseases, including HIV, influenza, malaria and others. And there are ongoing clinical trials using RNA to treat cancer. We’ll likely also see clinical trials for RNA therapeutics for autoimmune diseases, too. So, it’s hit the mainstream, and people are looking at it as a potential new therapy.

I’m also speaking with institutions that treat genetic diseases that afflict only 200 people. There is such a small population affected that no pharmaceutical company, and very few academics, are interested in researching them. But there is potential for RNA to be the key to treatment of these diseases because instead of having to reinvent the gene therapy for each disease, we can use the RNA platform we’ve already developed and easily plug in different diseases. We don’t have to spend $100 million in research to make a new treatment.

CNN: What does the world need to do to better utilize RNA technologies to fight diseases in the future?

Weissman: We need to develop the infrastructure to make new medicines, new vaccines, new therapies available to the world. I’ve been working with a lot of low- and middle-income countries to help them develop RNA therapeutics. Take Thailand: Through support from its government and charitable donations, Thailand was able to fund the development of an mRNA vaccine, which is currently in clinical trials, and could be distributed through Southeast Asia.

And it’s not just Covid vaccines. If countries have the infrastructure to produce RNA therapeutics, they could potentially protect their people from some of the biggest infectious diseases. So, the most important thing is building the infrastructure where it’s needed.






[link to www.cnn.com (secure)]

Last Edited by Digital mix guy Spock on 12/14/2022 09:57 AM

Sara Lee, a 2015 winner of the World Wrestling Entertainment reality competition series “Tough Enough,” has died, according to a statement from her mother shared on social media. She was 30.

“It is with heavy hearts that we share the news that our Sarah Weston has gone to be with Jesus,” her mother, Teri Lee, wrote in a statement. “We are all in shock and arrangements are not complete. We ask that you respectfully let our family mourn.”

Sara Lee was married to former WWE wrestler Westin Blake. They are parents to three children.

[link to www.cnn.com (secure)]

Sara Lee died on October 5, 2022, at the age of 30. Her cause of death was not made publicly available.


[link to en.wikipedia.org (secure)]

I lost my favorite younger sister to cancer years back. When looking through alternative treatments I found the Italian doctor who believes cancer is a fungus and a few who agree.

After reading through a bunch of posts on the two fungus threads I am more convinced than ever that fungus is a root cause of much disease. And a diet that is long on sugar and flour is a diet that feeds fungus.

And the doctors are a bunch of quacks.

Thread: Cosmic Death Fungus - General

for melanoma?

rick simpson oil works instead of gene altering

It's true; fatal heart attacks cure terminal cancer.

An answer, instead of conjecture, sure would be fucking nice.
Just saying.

That's like claiming a hooker is a herpes vaccine.

This mRNA crap will be injected into all food animals and probably put in the soil to fertilize plants. Our food will be compromised. Maybe they will chemtrail it so all the water supplies are contaminated.

Depopulation and enslavement via mRNA!