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11/08/2008 03:47 AM
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For coolhandluke74 or others interested in cancer help
By Archimedeon March 8, 2007 10:17 AM | Permalink | Comments (1)
Is Cancer Caused by the Candida Fungus?
Interview with Doctor Tullio Simoncini
By Emma Holister



EH: Having read your articles about your revolutionary cancer therapy, I cannot help but wonder how difficult it has been for you to continue working as an oncologist in the world of mainstream medicine. What has been the response of the medical authorities to your work?

TS: Suppression. Plots. Defamatory TV programs. When a scientist has an effective and revolutionary idea, the medical institution attempts to suppress his work because he threatens the interests of the ruling class. No matter how effective the therapy in question is, their aim will be to destroy him.

Those in power ensure that the following things are put into action:

1) dismissal from the medical associations,
2) instigation of newspaper and TV campaigns portraying him as a charlatan,
3) mounting attacks against him from the judicial system,
4) constant police harassment at home.

EH: What are the things preventing our current medical system from embracing your theories about cancer being caused by a fungus (Candida) and your treatment of tumours using bicarbonate of soda?

TS: One: there is a selfishness and lack of spirituality within the medical ruling class. It prevents them from looking beyond their acquired ignorance. Two: the fundamental theory behind cancer is based on the hypothesis that it is caused by a genetic disorder resulting in an over-reproduction of the cancerous cells. This theory is simply wrong and has never been demonstrated.

EH: Do you believe these problems can be overcome, and if so, how?

TS: Yes, I do. It will be achieved through grassroots activism, which will establish freedom in medical research. If large numbers of people in a country gather and work together, it is possible to demand that the authorities allow for freedom in medical research. This can be done through demonstrations and informing people via the media.

EH: How many cases of cancer have you been able to cure? Surely your results must have at least attracted the attention of your colleagues in the medical world?

TS: I have treated hundreds of patients. Most of them had extremely advanced cancer, especially after having been subjected to conventional therapies. Many of them made a complete recovery and are still alive and well years after the treatment.

In the cases of cancers caught early (lumps smaller than 3cm, with minimal incidence of metastasis) 90% of patients have made a recovery.

Many doctors agree with my methods and have used the sodium bicarbonate treatment.

EH: Is there no way that you could use this evidence to put pressure on the establishment to take your work more seriously?

TS: No, because it is necessary to demonstrate one?s results with many hundreds of fully documented cases. This is not possible unless you work in a cancer clinic.

EH: Many women suffering from Candida are plagued by persistent long-term gynaecological problems, from thrush to reproductive cancers. What would be your advice to them?

TS: To uproot persistent gynaecological fungal infections one should do a douche every day with two litres of pure water (that has been boiled and left to cool) containing two dissolved tablespoons of bicarbonate of soda. This should be kept up for two months, stopping only during one?s period. Candida is very persistent and it takes a long time to kill an infection.

EH: Although your views on cancer and fungus are revolutionary within the context of mainstream medicine, within alternative medicine your views of what Candida is and how it functions in the body appear to differ from many alternative practitioners who view Candida as a systemic problem affecting the whole body and originating in the intestines. From what I gather you do not see the Candida problem as residing in the gut. If you believe that the Candida yeast is not the cause of the various intestinal problems usually associated with Candidiasis, what in your opinion is the cause?

TS: The main cause is environmental. Secondly, there is a resulting lack of energy caused by alterations in the blood circulation. Thirdly, diet. The problem is, why does a person have intolerances to sugar, yeast, eggs, milk etc? Before these developed, damage had been caused. The gut?s epithelium is impaired and that causes the intolerances. It is important to cure this, and then it is possible to see if the related problems continue.

It is not good to avoid a particular food for ever, because it doesn?t deal with the root cause of the illness, which is usually caused by problems within the environment, from impaired energy levels and poor diet.

For example, a person who has heart disease may suffer from chronic dilatation of the gut (in this way the heart works less), and an intolerance is the result . . . Another example is a person who suffers from cooling syndrome. This provokes congestion and consequently intolerances. And so on.

Therefore it is necessary to cure the illness at its root cause, not just the symptoms by avoiding this or that food.

EH: Finally, what is your opinion of the situation that many alternative health practitioners find themselves in with regard to the anti alternative medicine campaigns being waged against them by the medical authorities, the medical press and national media, for example Quackbusters? What do you feel is needed to protect alternative therapists such as yourself, and the patients who come to you for help?

TS: My opinion is that the alternative practitioners are scared and don?t have the means to fight the lies perpetrated by mainstream medicine. The medical world needs to be liberated in order to allow patients freedom of choice in healthcare. Most illnesses are the result of an unhealthy lifestyle, and as such, drugs are useless and can only do damage. Furthermore, archaic institutions such as the medical associations frequently pressure doctors into prescribing only useless, toxic and harmful treatments.

CANCER AND FUNGUS

A Path of Personal Research

By Dr Tullio Simoncini

One of the questions that I am asked most frequently when the issue of this new anti-cancer therapy comes up is how it all began, how the idea first struck me that cancer could be a fungus, and the motives and events that induced me to drift away from official oncology. It all began when I was attending an introductory course in histology. When the professor described tumours as some terrible and mysterious monster, I felt indignant ? as one does if told ?Everyone is powerless before me? ? that was the implicit threat when it came to cancer ? ?your minds are too small to understand me.?

That was when the war began, my personal war against cancer. I was aware that I could win it only by focusing all my resources and mental energy - conscious and unconscious - in the right direction. And I believed this could only be found by using a critical approach to the official line of thought, a line of thought which is built on many unknowns and very few certainties.

The biggest task, therefore, consisted initially of acquiring the necessary knowledge for this research, and at the same time putting anything that I was studying under critical analysis. In other words I had to keep in mind that everything I was learning might well be false.

So, as the years went by my convictions deepened ? particularly later, when working in hospital wards, where I realised that medicine was not only unable to resolve the cancer problem, but also that of the majority of diseases. Which is still, unfortunately, true today. This is because, apart from success in various sectors in the treatment of specific symptoms of these diseases, medicine is unable to offer any conclusive benefit. Hypertension, diabetes, epilepsy, psoriasis, asthma, arthritis, Crohn?s Disease, and many more are typical examples of this.

Apart from my distrust with regard to the effectiveness of medicine, over time my experience in the clinical field had begun to weigh upon me so heavily that I was finding it difficult to deal with. These feelings were aggravated each time I was faced with desperate cases. This led to a crisis where I at first wanted to leave. However, it then turned into a desire to stay on and ?fight in the trenches? in order to think about and develop new solutions.

Little by little, working endless hours in the university?s paediatric oncology emergency ward, where I was finishing my thesis, my mind began to explore. Towards the end I was finding it painfully difficult to see the patients, their relatives, my professors, colleagues, the nurses - even people in general, such were my feelings of alienation in a system that I believed to be totally bankrupt.

I was wondering, ? ?and my profession, the university career, my social position, what will happen to them??

After all, it would have been very difficult to survive on ideas alone, especially in a medical world where job opportunities were diminishing on a daily basis to the extent that there were very few possibilities of employment worth considering.

On the other hand, I was not particularly attracted to the university environment. In fact, I saw it as an enmeshed and unpleasant entity that prevented the achievement of any scientific goal; distracting, as it does, the best intellectual and personnel resources from science by channelling them towards irrelevant and superficial arguments.

From that point on it was clear which direction I was to take. I left the faculty of medicine and enrolled for a physics degree. I studied for several years in order to develop a more scientific mind-set and in order to explore the infinite aspects of research in detail.

At the same time, I started to investigate other medical approaches including alternative medicine which, although officially ridiculed, had many followers, especially amongst those patients who could not endure excessively aggressive therapeutic methods. Experience after experience led me to understand that the raison d??tre of these alternative methods was to fill the gap left by conventional medicine and its inability to solve the patients? problems. The patients seemed to get greater benefit from those therapies that evaluated them and treated them as a whole being and not simply with unsatisfactory treatments for their symptoms.

It was when I was setting up a naturopathic practice that I had the idea of cancer?s being caused by fungus. When I was treating a patient who had psoriasis, using corrosive salts, I realised that the salts worked because they were destroying something ? and that something was fungus.

From that realisation I deduced the solution I had been so long searching for: if psoriasis, an incurable disease, is caused by a fungus, then it is possible that cancer, another incurable disease, could be caused by a fungus. That link was what started all the experiences, the experiments, the verifications and the results, through relentless and ?underground? work that brought great professional satisfaction to me and that allowed me to perfect a therapy that is very effective against tumorous masses, that is, against fungal colonies.

Once the causal role of fungus in tumour proliferation was hypothesised, the problem of how to attack it in deep internal tissue arose, since in those areas it was not possible to use salts that were too strong. It then occurred to me that with oral-pharyngeal candidiasis of breastfed babies, sodium bicarbonate was a quick and powerful weapon capable of eliminating the disease in three or four days. I thought that if I could administer high concentrations orally or intravenously, I might be able to obtain the same result. So I started my tests and my experiments, which immediately provided me with tangible results.

Amongst these, one of the first patients I treated was an 11-year-old child, a case which immediately indicated that I was on the right track. The child arrived in a coma at the paediatric haematology ward around 11:30 in the morning, with a clinical history of leukaemia. Because of the child?s disease he had been taken from a small town in Sicily to Rome, through the universities of Palermo and Naples, where he underwent several chemotherapy sessions. His desperate mother told me that she had been unable to speak with the child for 15 days; that is, since the child had been on his journey through the various hospitals. She said she would have given the world to hear her son?s voice once again before he died. As I was of the opinion that the child was comatose both because of the proliferation of fungal colonies in the brain and because of the toxicity of the therapies that had been performed on him, I concluded that if I could destroy the colonies with sodium bicarbonate salts and at the same time nourish and detoxify the brain with glucose administered intravenously, I could hope for a regression of the symptoms.

And so it was. After a continuous intravenous infusion of bicarbonate and glucose solutions, at around 7pm, when I returned to the university, I found the child speaking with his mother, who was in tears.

Since then, I have continued in this field and I have been able to treat and to cure several people, mostly during a period of three years when I was a voluntary assistant at the Regina Elena Tumour Institute in Rome. In 1990, although my time was almost totally occupied with work in a centre for diabetes, owing to changes in my personal life I decided to increase my research in the field of cancer, a disease that was always foremost in my mind, although I had in recent years been forced to neglect it.

Before resuming my combat against cancer, however, I felt the need to better explore the rationale of medicine and therefore of oncology so that I could acquire the intellectual, critical and self-critical attributes necessary in order to understand where hidden errors may lie.

I enrolled for a philosophy degree, which I completed in 1996. That was the year when, feeling more composed, I began making contacts within the world of oncology again, attempting first of all to make my theories and treatment methods known, especially within the more accredited institutions.

So, the Ministry of Health, the Italian and foreign oncology institutes, and oncology associations were made aware of my research and my results - but there was no acknowledgement at all. All I encountered were colleagues, variously qualified, who tended to be condescending and who seemed only capable of uttering the magic word: genetics.

I thought to myself ?This will lead us nowhere?. In fact, I found myself in a situation with no way out. I had so many great ideas and some positive results, but no opportunity to check them with patients affected by tumours, in an authoritative scientific context.

I decided to be patient and to continue getting results, treating patient after patient and at the same time trying to become known by as many people as possible, especially in the field of alternative medicine where at least there was an openness and an opportunity to contact professionals who already had a critical attitude towards official medical thought. It was during that time that, for lack of any alternative, I started my research on the Internet. And I soon found contacts, friends and consensus, all of which allowed me to spread my theories, but ? even more importantly ? they gave me the psychological thrust necessary to continue my personal fight against the sea of sterility and self-evidence that exists in mainstream medicine.

I took comfort from the knowledge that my idea, my little torch, would not go out but could take root somewhere. I started to hope again that, given the validity of the message, sooner or later it would find a way to being shared and accepted by an ever-growing number of people. Slowly, in that way, I was able to get my theory about cancer known and to share it with the public at conferences, in interviews and at conventions. All that widened my field of action and gave me the opportunity to accumulate a remarkable amount of experience and of clinical results.

Friends pointed out to me, however, that my therapies with sodium bicarbonate solution, although they were effective, needed to evolve in terms of their methodology, as some types of cancer could either not be reached in any way or at least reached insufficiently.

Sodium bicarbonate administered orally, via aerosol or intravenously can achieve positive results only in some tumours, while others ? such as the serious ones of the brain or the bones - remain unaffected by the treatment. These were the reasons I got in touch with several colleagues, especially interventionist radiologists, and I was finally able to reach those areas of the body that had previously been inaccessible. This was achieved through positioning appropriate catheters either in cavities for peritoneum and pleura, or in arteries to reach other organs.

SELECTIVE ARTERIOGRAPHY

By Tullio Simoncini

The basic concept of my therapy is the administration of a solution with a high content of sodium bicarbonate directly onto tumours. These are susceptible to regression only if one destroys the fungal colonies.

It was the ongoing search for ever more effective techniques to allow me to get as close as possible to the inner tissues that led me to the idea of selective arteriography (visualisation using instruments on specific arteries) and positioning an arterial port-a-cath (devices joining the catheter). These methods make it possible to place a small catheter directly into the artery that nourishes the tumour, and administer high doses of sodium bicarbonate to the deepest recesses of the tumour

In the past, for example, when I had the opportunity to treat a brain tumour, although I was able to improve the condition of the patient, I could not treat the tumorous mass at a deep enough level. I have countless times wasted my breath begging neurologists and neurosurgeons to perform the operation of inserting the catheter so that I could use it to do a further local treatment.

Today, with selective arteriography of carotids, it is possible to reach any cerebral mass without surgical intervention and in a completely painless manner. By the same token, almost all organs can be treated and can benefit from bicarbonate salts therapy, which is harmless, fast and effective ? with only the exception of some bone areas such as vertebrae and ribs, where the scarce arterial irrigation does not allow sufficient dosage to reach the targets.

Selective arteriography therefore represents a very powerful weapon against fungus that can always be used against tumours, firstly because it is painless and provokes no side effects, and secondly because the risks are very low.

Technically, it is performed as follows: after sterilising and anaesthetising the surface levels, a needle is introduced into the artery that is to be used as an inlet port (usually the sub-clavian); then a metal guide that is visible to the angiologist is inserted and can be used to locate the selected artery. The last step consists of getting the small catheter to administer the solution where necessary. Then the catheter is fitted to a subcutaneous port-a-cath that stays in the selected location as long as necessary.

This very low-risk intervention creates no more pain than an intravenous injection and allows patients to be treated at home, although under constant medical supervision.

Tullio Simoncini's website: www.curenaturalicancro.org


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Baking Soda and Maple Syrup Cancer Treatment



Tonight we are going back to medical basics with the application of the least expensive, safest and perhaps most effective cancer medicine there is. Sodium bicarbonate has been on many cancer patients? minds this past year. It has not been easy though to get to Rome or even contact Dr. Tullio Simoncini for treatment. And doctors willing to give bicarbonate IVs are not on every corner so it?s been somewhat frustrating to have something so simple and effective remain elusive. If doctors doing such treatments want to be listed by the IMVA for referral please contact us.



Though we have known that oral intake of sodium bicarbonate will have the ?Simoncini? effect on oral, esophagus and stomach cancer we have not focused at all on the systemic effect of bicarbonate taken orally. Every cancer patient and every health care practitioner should know that oral intake of sodium bicarbonate offers an instant and strong shift of blood pH into the alkaline. So strong is the effect that athletes can notice the difference in their breathing as more oxygen is carried throughout the system and as more acids are neutralized. The difference can be stunning for those whose respiration is labored under intense exercise loading.[ii] This tells us to take very seriously the oral use of bicarbonate for cancer treatment no matter what other treatment is used.

This diagram shows the diffusion directions for H+, CO2, and O2 between the blood and the muscle cells during exercise. The resulting concentration changes affect the buffer equilibria, shown in the upper right-hand corner of the diagram (yellow). If the amounts of H+ and CO2 exceed the capacity of hemoglobin, they affect the carbonic acid equilibrium, as predicted by Le Ch?telier's Principle or the quantitative treatment in terms of equilibrium constants. As a result, the pH of the blood is lowered, causing acidosis. The lungs and kidneys respond to pH changes by removing CO2, HCO3-, and H+ from the blood.

When one reads my thesis on different medicinal substances one has to always remember that I am a protocol man who does not support single shot cures for anything. With the publication of today?s chapter on sodium bicarbonate and maple syrup sodium bicarbonate slips securely into the number three spot right behind magnesium chloride and iodine. Each of these three substances effects directly onto basic human physiology in a way most pharmaceutical drugs do not. When used together we have a super threesome that will inexpensively go far to resolving many of the physical and even some of the emotional problems we and our children face. And if you have not made the connection please note that all three of these substances are used in emergency rooms and intensive care wards and they do commonly save lives every day with their inherent healing powers. See my chapter on emergency room medicine and cancer treatment.


All cancer sufferers and in fact every chronic disease patient should hold clearly in mind that pH is the regulatory authority that controls most cellular processes. The pH balance of the human bloodstream is recognized by medical physiology texts as one of the most important biochemical balances in all of human body chemistry. pH is the acronym for "Potential Hydrogen". In definition, it is the degree of concentration of hydrogen ions in a substance or solution. It is measured on a logarithmic scale from 0 to 14. Higher numbers mean a substance is more alkaline in nature and there is a greater potential for absorbing more hydrogen ions. Lower numbers indicate more acidity with less potential for absorbing hydrogen ions.

Our body pH is very important because pH controls the speed of our body's biochemical reactions. It does this by controlling the speed of enzyme activity as well as the speed that electricity moves through our body; the higher (more alkaline) the pH of a substance or solution, the more electrical resistance that substance or solution holds. Therefore, electricity travels slower with higher pH. If we say something has an acid pH, we are saying it is hot and fast. Alkaline pH on the other hand, bio-chemically speaking, is slow and cool.



Body ph level changes are intense in the profundity of their biological effects. Even genes directly experience external pH. pH differentially regulates a large number of proteins. Increased oxidative stress, which correlates almost exponentially with ph changes into the acidic, is especially dangerous to the mitochondria, which suffer the greatest under oxidative duress. Epigenetics, which may now have begun eclipsing traditional genetics, commonly describes how factors such as diet and smoking, rather than inheritance influence how genes behave.

The following chapter comes after 100 pages of text in the Yeast and Fungi Invaders section of the Winning the War on Cancer book. Please note that sodium bicarbonate taken in water alone will have a powerful effect on entire body physiology because of the instant shift into alkaline pH levels. Bicarbonate can be taken frequently throughout the day with half teaspoons amounts though for long term use lower doses are safer. For cancer patients initial use should be heavy and frequent to force a greater shift because smaller pH shifts can actually stimulate cancer growth.



Common sense knowledge speaks loudly about cancer and Candida patients avoiding glucose. This is similar to the common sense of pilots who know to pull back on the stick to pull out of a dive. That works until you approach the speed of sound and at that point all the pulling in the world will not work. You have to push the stick forward and do what instincts scream not to do. Several died trying until Chuck Yeager pushed that stick forward and became the first man to break the speed of sound.


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Bicarbonate Maple Cancer Treatment

International Medical Veritas Association


The bicarbonate maple syrup cancer treatment focuses on delivering natural chemotherapy in a way that effectively kills cancer cells but significantly reduces the brutal side effects experienced with most standard chemotherapy treatments. In fact so great is the reduction that the dangers are brought down to zero. Costs, which are a factor for the majority of people, of this particular treatment are nil. Though this cancer treatment is very inexpensive, do not assume it is not effective. The bicarbonate maple syrup cancer treatment is a very significant cancer treatment every cancer patient should be familiar with and it can easily be combined with other safe and effective natural treatments.



This cancer treatment is similar in principle to Insulin Potentiation Therapy (IPT). IPT treatment consists of giving doses of insulin to a fasting patient sufficient to lower blood sugar into the 50 mg/dl. In a normal person, when you take in sugar the insulin levels go up to meet the need of getting that sugar into the cells. In IPT they are artificially injecting insulin to deplete the blood of all sugar then injecting the lower doses of toxic chemo drugs when the blood sugar is driven down to the lowest possible value. During the low peak, it is said that the receptors are more sensitive and take on medications more rapidly and in higher amounts.

The bicarbonate maple syrup treatment works in reverse to IPT. Dr. Tullio Simoncini acknowledges that cancer cells gobbles up sugar so when you encourage the intake of sugar it?s like sending in a Trojan horse. The sugar is not going to end up encouraging the further growth of the cancer colonies because the baking soda is going to kill the cells before they have a chance to grow. Instead of artificially manipulating insulin and thus forcefully driving down blood sugar levels to then inject toxic chemo agents we combine the sugar with the bicarbonate and present it to the cancer cells, which at first are going to love the present. But not for long!

This treatment is a combination of pure, 100% maple syrup and baking soda and was first reported on the Cancer Tutor site. When mixed and heated together, the maple syrup and baking soda bind together. The maple syrup targets cancer cells (which consume 15 times more glucose than normal cells) and the baking soda, which is dragged into the cancer cell by the maple syrup, being very alkaline forces a rapid shift in pH killing the cell. The actual formula is to mix one part baking soda with three parts (pure, 100%) maple syrup in a small saucepan. Stir briskly and heat the mixture for 5 minutes. Take 1 teaspoon daily, is what is suggested by Cancer Tutor but one could probably do this several times a day.

?There is not a tumor on God?s green earth that cannot be licked with a little baking soda and maple syrup.? That is the astonishing claim of controversial folk healer Jim Kelmun who says that this simple home remedy can stop and reverse the deadly growth of cancers. His loyal patients swear by the man they fondly call Dr. Jim and say he is a miracle worker. ?Dr. Jim cured me of lung cancer,? said farmer Ian Roadhouse. ?Those other doctors told me that I was a goner and had less then six months to live. But the doc put me on his mixture and in a couple of months the cancer was gone. It did not even show up on the x-rays.?

Dr. Jim discovered this treatment accidentally somewhere in the middle of the last century when he was treating a family plagued by breast cancer. There were five sisters in the family and four of them had died of breast cancer. He asked the remaining sister if there was anything different in her diet and she told him that she was partial to sipping maple syrup and baking soda. Since then, reported by a newspaper in Ashville, North Carolina, Dr. Jim dispensed this remedy to over 200 people diagnosed with terminal cancer and amazingly he claims of that number 185 lived at least 15 more years and nearly half enjoyed a complete remission of their disease. When combined with other safe and effective treatments like transdermal magnesium therapy, iodine, vitamin C, probiotics and other items like plenty of good sun exposure, pure water and clay treatments we should expect even higher remission rates.

It is very important not to use baking soda which has had aluminum added to it. The Cancer Tutor site reports that Arm and Hammer does have aluminum but the company insists that is not true. One can buy a product which specifically states it does not include aluminum or other chemicals. (e.g. Bob's Red Mill, Aluminum-Free, Baking Soda). Sodium bicarbonate is safe, extremely inexpensive and unstoppably effective when it comes to cancer tissues. It?s an irresistible chemical, cyanide to cancer cells for it hits the cancer cells with a shock wave of alkalinity, which allows much more oxygen into the cancer cells than they can tolerate. Cancer cells cannot survive in the presence of high levels of oxygen. Studies have already shown how manipulation of tumor pH with sodium bicarbonate enhances some forms of chemotherapy.[iii]


"The therapeutic treatment of bicarbonate salts can be administered orally, through aerosol, intravenously and through catheter for direct targeting of tumors," says oncologist Dr. Tullio Simoncini. ?Sodium bicarbonate administered orally, via aerosol or intravenously can achieve positive results only in some tumors, while others ? such as the serious ones of the brain or the bones - remain unaffected by the treatment.?

The maple syrup apparently enables and increases penetration of bicarbonate into all compartments of body, even those which are difficult or impossible to penetrate by other means. These compartments include the central nervous system (CNS), through the blood-brain barrier, joints, solid tumors, and perhaps even the eyes. IPT makes cell membranes more permeable, and increases uptake of drugs into cells. The maple syrup will make tissues more permeable, too. It will transport the bicarbonate across the blood-brain barrier and every other barrier in the body for sugar is universally needed by all cells in the body. The essence of IPT is that it allows cancer drugs to be given in a smaller dose, far less toxic to normal cells, while building up lethally toxic concentrations in cancer cells. Both IPT and bicarbonate maple syrup treatments use the rabid growth mechanisms of the cancer cell against them.

Dr. Jim did not have contact with Dr. Simoncini and did not know that he is the only oncologist in the world who would sustain the combining of sugar with bicarbonate. Dr. Simoncini always directs his patients to dramatically increase sugar intake with his treatments but has never thought to mix the two directly by cooking them together. Because his treatments depend on interventionist radiologists who insert catheters to direct the bicarbonate as close to the affected area as possible, or physicians willing to do expensive intravenous treatments, I pushed bicarbonate up into the number six slot in the IMVA cancer protocol. With the discovery of Dr. Jim?s work bicarbonate comes back into our number three spot right behind magnesium chloride and iodine.

That number three slot for a brief time was held by hemp oil containing THC. The great advantage that maple syrup and bicarbonate treatment has over this type hemp oil is that it is legal thus easily obtainable. The two together, backed by a solid protocol of other nutritional substances makes winning the war on cancer almost a certainty. When using these substances it is safer to change one?s vocabulary and not say one is treating and curing cancer. Far better to conceptualize that one is treating the infectious aspect of cancer, the fungus and yeast colonies and the yeast like bacteria that are the cause of TB.

Dr. Simoncini says that, ?In some cases, the aggressive power of fungi is so great as to allow it, with only a cellular ring made up of three units, to tighten in its grip, capture and kill its prey in a short time notwithstanding the prey's desperate struggling. Fungus, which is the most powerful and the most organized micro-organism known, seems to be an extremely logical candidate as a cause of neoplastic proliferation.?

pH of the blood is the most important factor to
determine the state of the microorganisms in the blood.

"Sodium bicarbonate therapy is harmless, fast and effective because it is extremely diffusible. A therapy with bicarbonate for cancer should be set up with strong dosage, continuously, and with pauseless cycles in a destruction work which should proceed from the beginning to the end without interruption for at least 7-8 days. In general a mass of 2-3-4 centimeters will begin to consistently regress from the third to the fourth day, and collapses from the fourth to the fifth," says Dr Simoncini.



There are many ways to use sodium bicarbonate and it is a universal drug like iodine and magnesium chloride. Raising pH increases the immune system's ability to kill bacteria, concludes a study conducted at The Royal Free Hospital and School of Medicine in London. Viruses and bacteria that cause bronchitis and colds thrive in an acidic environment. To fight a respiratory infection and dampen symptoms such as a runny nose and sore throat, taking an alkalizing mixture of sodium bicarbonate and potassium bicarbonate will certainly help.

The apple cider vinegar 1/4 teaspoon and 1/4 teaspoon baking soda taken 2 times or more a day is another treatment as is lemon and baking soda, or lime and baking soda formulas. Perhaps honey could be substituted for maple syrup for those who live in parts of the world where maple syrup is not available but to my knowledge no one has experimented with this.


Mark Sircus Ac., OMD
Director International Medical Veritas Association
[link to www.imva.info]
[link to www.magnesiumforlife.com]
[link to www.winningcancer.com]

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The breakdown of glucose or glycogen produces lactate and hydrogen ions - for each lactate molecule, one hydrogen ion is formed. The presence of hydrogen ions, not lactate, makes the muscle acidic that will eventually halt muscle function. As hydrogen ion concentrations increase the blood and muscle become acidic. This acidic environment will slow down enzyme activity and ultimately the breakdown of glucose itself. Acidic muscles will aggravate associated nerve endings causing pain and increase irritation of the central nervous system. The athlete may become disorientated and feel nauseous.

[ii] By buffering acidity in the blood, bicarbonate draws more of the acid produced within the muscle cells out into the blood and thus reduce the level of acidity within the muscle cells themselves.

[iii] Enhancement of chemotherapy by manipulation of tumour pH. Raghunand N, He X, van Sluis R, Mahoney B, Baggett B, Taylor CW, Paine-Murrieta G, Roe D, Bhujwalla ZM, Gillies RJ. Arizona Cancer Center.




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WINNING THE WAR ON CANCER - DR MARC SIRCUS



Emergency Room Medicine for Cancer Treatment
Deep within the heart of western medicine is a wisdom and power that is deliberately stymied by medical authorities. Inside the emergency room and intensive care wards, where many believe some of the most accurate medicine is practiced, are common but extraordinarily safe and effective substances that save lives everyday. Interesting no one has thought to harness these medical super weapons against cancer. Winning the War Against Cancer entails trapping cancer tumors in a lethal cross fire of concentrated nutritional substances. Read more...
Winning or Losing the War on CancerResearchers at the National Bureau of Economic Research have found that chemotherapy for non-small cell lung cancer in people 65 and older has a minimal impact on survival. We have been fighting the wrong war, with the wrong weapons, against the wrong enemies for decades and the results are disgusting. Our loved ones are dying all around us and we wonder if we are next. Read more...
InformationsCorruption at the FDA - Provenge, an immunotherapy for end-stage prostate disease rejected by the FDA. Read more...

Simoncini Cancer Treatment - As approved by the FDA for cardiac infarctions intravenous sodium bicarbonate to treat most cancers. Read more...

Cancer and Fear - Devastating effects of chemotherapy and radiation, slow lingering deaths, are they from the cancer or the treatments? Read more...
Natural Allopathic MedicineCancer is a prime example of how heavy metal toxicity, free radical damage, pathogen infection, mineral and vitamin deficiencies, inflammation, mitochondria dysfunction, immune system depression, genetic mutation, cell wall damage and oxidative stress all come together into an end stage life threatening condition. Cancer treatment can be approached in many ways but the best way would be to address all these problems simultaneously. Read more...
The Condition of Cancer "I believe that, 15 to 20 percent of all cancer is caused by infections; however, the number could be larger - maybe double," said Dr. Andrew Dannenberg, director of the Cancer Center at New York-Presbyterian Hospital/Weill Cornell Medical Center." Dr. Dannennberg made the remarks in a speech in December 2007 at the annual international conference of the American Association for Cancer Research. Read more...
Trust your Oncologist? A mistake with trust at this exact moment in your life could cost you your life. Oncologists use treatments that cause cancer to treat cancer. Your doctor will almost always understate the risks and dangers of the drugs, tests, radiation and surgery. Beware and proceed with care. Polls show that three doctors out of four would refuse any chemotherapy because of its ineffectiveness against the disease and its devastating side effects. Read more...
MethodologyThe best way to treat cancer is to stimulate the body's own resources to destroy the invading intruders, the colonies of yeast and fungus that cancer is - plus restore and revitalize human cells that are in a state of malfunction and decay. The immune system is the key to both fighting and preventing cancer. It is a fluid network designed to protect us from agents of disease. Read more...
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Table of Contents

About the Author

ArticlesCancer and Fear

Corruption at the FDA Betrays Prostate Cancer Patients

Costs of Cancer Treatments

Emergency Room Medicine and Cancer Treatment

Fundamental Methodology

Natural Allopathic Medicine

Should you trust your Oncologist

Natural Allopathic Medicine

The Simoncini Treatment of Cancer

Understanding the Condition of Cancer

Winning or Losing the War on Cancer
"If you can't speak freely, you're simply not free" - Montagraph

"Truth does not fear investigation" - Clear Eyes
Dr. Woo  (OP)

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11/08/2008 04:02 AM
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Re: For coolhandluke74 or others interested in cancer help
The following may have errors due to the scanning process, but should be a good start for further research by those interested

CLINICAL RESEARCH USING MGN-3
(ARABINOXYLANE COMPOUND)
IMMUNOMODULATORY AND ANTI·CANCER PROPERTIES OF (MGN·3), A MODIFIED XYLOSE FROM RICE BRAN, IN 5 PATIENTS WITH BREAST CANCER
Ghoneum M.
Cancer: The Interface Between Basic and Applied Research November 5·8,1995 Baltimore, MD
MGN·3 is a new biological response modifier (BRM). It is an extract of arabinoxylane from rice bran that has been enzymatically modified to increase it's immunomodulatory function. Five patients with breast cancer were given MGN-3 at 3g/d, then NK cell activity was measured by 4·hr. 51Cr·release assay using K562 tumor cells as targets.
Resu Its showed that:
patients had low level of basal NK activity (13.5·34.9%), at effector to target (E:T) ratios of 12 and 100:1, that was significantly enhanced by MGN-3 treatment (21.1·50.1%) at the same E:T ratios.
The augmentation in NK activity was detected as early as 1-2 weeks post treatment and was fu rther increased with continuation of administering MGN·3.
Two patients who participated early in the study (6·8 mon.) are in complete remission. We conclude the high augmentory effect of MGN·3 on NK cells and the absence of notable side effects make MGN-3 a promising BRM. In addition, immunotherapeutic effect of MGN-3 in conjunction with chemotherapy may be useful in treatment of cancer patients. MGN·3 was offered by Daiwa Pharmaceutical Co., Ltd. 1-16-19, Sangenjaya,Setagaya.
ANTI-HIV ACTIVITY BY MGN-3, IN VITRO
Ghoneum, M.
XI International Conference on AIDS
July 7-12,1996, Vancouver, BC
Obiectiv~
To examine the effect of MGN·3 on HIV induced syncytia formation (SF) In Vitro. MGN·3 is an arabinoxylane from rice bran, that is enzymatically treated with an extract from Hyphomycetes mycelia.
Method
Peripheral Blood lymphocytes (PBl) from AIDS patients were cultured with PHA in the presence or absence of different concentrations of MGN-3 (12.5-100 ug/ml) for 7 days. The number of synctia were evaluated, and the size of each was also recorded. The effect of MGN·3 on PHA induced PBl proliferation was studied by MTI assay.
Results
Treatment with MGN·3 resulted in:
Significant inhibition in the SF.
The effect was dose dependent, percentage of inhibition in SF was 38.5, 50, 62.5, and 75% at concentrations of 12.5, 25, 50, and 100 ~g/ml respectively;
Complete absence of SF having large and medium size post treatment, and
4) MGN-3 caused 25·30% inhibition of PBl proliferation
Conclusion
We conclude that MGN-3 is a natural product that possesses a potent effect against synctia formation by HIV. This property of MGN-3 may be of poten­tial value in therapy of HIV infection.
EFFECT OF MGN·3 ON HUMAN NATURAL KILLER CEll ACTIVITY AND INTERFERON·y SYNTHESIS IN VITRO
Ghoneum M., Namatalla G., and Kim C.
FASEB JOURNAL
June 2·6, 1996, New Orleans, lA
MGN·3 is an extract of arabinoxylane from rice bran that has been enzymatically treated with an extract from Hyphomycetes mycelia. In this study we investigated the effect. MGN-3 on natural killer (NK) cell activity and interferon-y (IFN·y) synthesis by peripheral blood mononuclear cells (MNC). MNC was prepared from peripheral blood of healthy individuals and incubated with various concentrations of MGN·3 for 16 hrs., and then NK cell activity was measured by 4 hr. Cr·release assay using K56 Tumor cells as target NK activity was significantly enhanced (2·5 fold) by treatment with MGN-3 at 0-100 ug/ml. In an attempt to investigate the mechanism by which MGN-3 enhances NK activity, we examined the effect of MGN-3 on IFN·y production by MNC. Culture supernatants of the cells incubated with MGN-3 were collected and analyzed for INF·y synthesis by ELISA. INF-y production was increased >2 fold. We concluded that MGN-3 is a potent biological response modifier (BRM) and may be useful in immunotherapy of cancer. MGN·3 was offered by Daiwa Pharmaceutical Co. Ltd. Tokyo-Japan.
NK IMMUNORESTORATION OF CANCER PATIENTS BY MGN·3, A MODIFIED ARABINOXYLANE RICE BRAN
(Study of 32 Patients Followed for up to 4 Years).
Ghoneum M. and Jim Brown.
Drew University of Medicine and Science,
Department of Otolarynngology
NK cells have been characterized as non·B cells or non·T cells lacking the characteristics of mature macro phages which develop from the bone marrow independently of thymic influence. NK cells playa crucial role in tumor rejection, immune surveillance, resistance to infections, and immune regulation. NK cell destruction of cancer cells involves a sequence of events. First, the NK cells recognizes and binds to the cancer cell. This process requires receptor-to-receptor interaction. Next, the NK cell releases granules which penetrate the cancer cell and ultimately kill it. The NK cell is then free to bind to another cancer cell and repeat the same process.
However, cancer cells know how to fight back in a sort of cell war. We found for the first time in our laboratory that cancer cells can destroyWBCs through the phenomenon of phagocytosis. We have observed three ways in which this is done. The cancer cell can extend two arms around the WBC or it can develop a cup-shaped opening where the WBC is drawn inside. A third way is for the cancer cell to extend a long arm to capture the WBC and finally draw it inside the cancer cell where it is digested. In addition, extensive work by others has shown that cancer cells secrete immune· suppressive substances which inhibit the function of the immune system.
Many attempts have been made in the last 25 years to strengthen the power of the immune system using different biological response modifiers (BRMs). These are substances originating from bacteria and fungi which possess immunoaugmentory properties. In addition, some kinds of cytokines serve as BRMs such as interferons, interleukin-2 and interleukin-12. There are two problems associated with these BRMs: 1 st) toxicity and 2nd) the development of hyporesponsiveness in which a single administration of the BRM can significantly enhance NK cell activity, but that repeated administration of the same BRM results in depression of NK cell activity. It is interesting to note that MGN-3 has advantages over other BRMs. It is nontoxic and has not shown hyporesposiveness in the four years that the patients have been followed. This work was undertaken in order to investigate the augmentory effect of a new BRM known as MGN-3 on NK cell function and T and B cell proliferation in 32 patients. Tumor·associated antigens were reported for selected patients.

CLINICAL RESEARCH USING MGN-3
(ARABINOXVLANE COMPOUND)
NK IMMUNOMODULATORY FUNCTION IN 27 CANCER PATIENTS BY MGN-3, A MODIFIED ARABINOXYLANE FROM RICE BRAN
Ghoneum M. Namatalla G.
87th Annual Meeting of the American Association for Cancer Research
April 20-24, 1996 Washington, DC
MGN-3 immunomodulatory function was examined in 27 cancer patients. MGN-3 is an arabinoxylane from rice bran that has been enzymatically modified by hyphomycetes mycelia. The patients had different types of advanced malignancies: 7 patients had breast CA, 7 prostate, 8 multiple myelome (MM), 3 leukemia, and 2 cervical. All patients were under treatment with conventional therapy and were also given 3g of MGN-3 daily. NK activity was examined at 2 weeks, 3 months and 6 months. Activity of NK cells was examined by 51Cr-release assay using K562 tumor cells as targets, at effector:target ratios from 12:1-100:1.
Results showed that:
Patients had low level of basal NK activity (10.8-40%),
treatment with MGN-3 caused a remarkable increase in NK activity at 2 weeks. The percentages of induction were as follows: breast Ca 154-332%, prostatic 174-384%, leukemia 100-240%, MM 100-537%, and cervical CA 100-275%,
enhancement of NK activity continues to rise at 3 and 6 months after treatment.
We conclude that the high augmentory effect of MGN-3 makes it a promising immunotherapeutic agent for treatment of cancer.
SYNERGISTIC EFFECT OF MODIFIED ARABINOXYLANE (MGN-3) AND LOW DOSE OF RECOMBINANT IL-2 ON HUMAN NK CELL ACTIVITY AND TNF PRODUCTION
Ghoneum M. Jewett A.
American Academy of Anti-Aging Medicine, Educational Conference
August 15-16, 1998 East Rutherford, NJ
We have recently shown the potent biological response modification of a new product called MGN-3, an arabinoxylane from rice bran that has been modified by extract from Hyphomycetes mycelia. MGN-3 possesses anti-HIV activity, NK immunomodulation and anti-cancer activity. Success with recombinant 1l:2 (rll:2) immunotherapy of human cancer appears to depend on the administration of high doses, which are frequently associated with excessive toxicity. Therefore certain modifications are greatly needed on the use of rll:2 at low doses without significant loss of anti-tumor efficacy. Experiments were designed to examine NK activity post culture human peripheral blood lymphocytes (PBL) with MGN-3 alone (1 mg/ml), rll:2 alone (500u/ml) and MGN-3 (1 mg/ml) plus r1L-2 (500u/ml). Results showed that MGN-3 and r1L-2 increase NK activity by 138.6% and 179.5% respectively. Interestingly a synergistic effect on NK activity was noticed post culture of PBL with MGN-3 and rll:2 (332.7% of control). The mechanism underlying this phenomenon is not fully understood but could be attributed to action of MGN-3 on TNF-a production. Results showed that TNF-a levels from control untreated PBL of 20 subjects was 195 pg/ml +/- 102. Treatment with rll:2 showed no change in TNF-a level (216pg/ml +/- 100), while MGN-3 significantly increased TNF-a production (5773pg/ml +/- 2653). On the other hand, a synergistic effect of MGN-3 plus r1L-2 resulted in a further increase of TNF-a production (8127pg/ml +/- 2587). We conclude that; I) MGN-3 is a potent TNF-a producer, and 2) the immunomodulatory function by low concentration of rll:2 on anti-tumor activity by NK cells could be greatly augmented by the concomitant use of MGN-3.
ENHANCEMENT OF HUMAN NATURAL KILLER CELL ACTIVITY BY MODIFIED ARABINOXYLANE FROM RICE BRAN (MGN-3)
Ghoneum M.
INTERNATIONAL JOURNAL OF IMMUNOTHERAPY XIV (i) (1998)
Summary: Arabinoxylane, from rice bran (MGN-3) was examined for its augmentory effect on human natural killer cell activity in vivo and in vitro. Twenty-four individuals were given MGN-3 orally at three different concentrations: 15, 30 and 45 mg/kg/day for 2 months. Peripheral blood lymphocyte-natural killer cell activity was tested by 51CR-release assay against K562 and Raji tumor cells at 1 week, 1 month and 2 months post-treatment and results were compared with baseline natural killer activity. Treatment with MGN-3 enhanced natural killer activity against K562 tumor cells at all concentrations used. In a dose-dependent manner, MGN-3 at 15 mg/kg/day increased natural killer activity after 1 month post-treatment (two-fold over control value), while significant induction of natural killer activity at 30 mg/kg/day was detected as early as 1 week post-treatment (2 1/2 times control value). Natural killer cell activity continued to increase with continuation of treatment and peaked (five-fold) at 2 months (end of treatment period). Increasing the concentration to 45 mg/kg/day showed similar trends in natural killer activity. However the magnitude in values was higher than for 30 mg/kg/day. After discontinuation of treatment, natural killer activity declined and returned to baseline value (14 lytic units) at 1 month. Enhanced natural killer activity was associated with an increase in the cytotoxic reactivity against the resistant Raji cell line. MGN-3 at 45 mg/kg/day showed a significant increase in natural killer activity after 1 week (eight-fold) and peaked at 2 months post-treatment (27 times that of baseline). Culture of peripheral blood lymphocytes with MGN-3 for 16 hours demonstrated a 1.3 to 1.5 times increase in natural killer activity over the control value. The mechanism by which MGN-3 increases natural killer activity was examined and showed no change in cluster of differentiation (CD) 16+ and C056+ CD3- of MGN-3 activated natural killer cells as compared with baseline value; a four-fold increase in the binding capacity of natural killer to tumor cell targets as compared with baseline value; and a significant increase in the production of Interferon-y (340-580 pg/ml). Postculture of peripheral blood lymphocytes with MGN-3 at concentrations of 25-100 ~g/ml. Thus, MGN-3 seems to act as a potent immunomodulator causing augmentation of natural killer cell activity, and with the absence of notable side-effects, MGN-3 could be used as a new biological response modifier having possible therapeutic effects against cancer.
ANTI-HIV ACTIVITY IN VITRO OF MGN-3,
AN ACTIVATED ARABINOXYLANE FROM RICE BRAN
Ghoneum M.
XI International Conference on AIDS JULY 7-12,1996, Vancouver BC
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 243,25-29 (1998), ARTICLE NO RC978047
MGN-3, an arabinoxylane from rice bran that has been enzymatically modified with extract from hyphomycetes mycelia, was tested for anti-HIV activity in vitro. MGN-3 activity against HIV-l (SF strain) was examined in primary cultures of peripheral blood mononuclear cells. MGN-3 inhibited HIV-I replication by: (1) inhibition of HIV-l p24 antigen production in a dose dependent manner; MGN-3 at concentrations of 12.5, 25, 50 and 100 ug/ml showed 18.3, 42.8, 59 and 75% reduction in p24 antigen, respectively; and (2) inhibition of syncytia formation maximized (75%) at concentrations of 100 ug/ml. Further studies showed that ingestion of MGN-3 at concentration of 15 mg/kg/day resulted in a significant increase in T and B cell mitogen response at 2 months after treatment: 146% for PHA, 140% for Con A and 136.6% for PWM mitogen. We conclude that MGN-3 possesses potent anti-HIV activity and in the absence of any notable side effects, MGN-3 shows promise as an agent for treating patients with AIDS.
1998 Academic Press.

One Sizeable Step for Immunology, One Giant Leap for Cancer Patients
by Mamdooh Ghoneum, PhD
Associate Professor and Chief of Research, Department of Otolaryngology, Charles D. Drew University; Research Associate, Department of Neurobiology, UCLA School of Medicine
Background
Although cymclsm and dis­illusionment with the failed "war against cancer" are widespread, I remain very optimistic that we will triumph over this seemingly invincible killer. Given the disappointing results and many drawbacks of cytotoxic therapies, it seems clear that our best hope for a decisive victory against cancer lies in immuno-augmentive therapies ~ those that enhance the body's innate immune response to cancer cells.
As a research immunologist, I have spent 18 years studying immuno­modulating substances - natural compounds derived from mushrooms, herbs, fungi, and bacteria, as well as synthetic drugs like Interleukin-2 and interferon. Approximately six years ago, I stumbled across a natural substance that was so promising, so profoundly superior to everything else I had ever evaluated, that I abandoned all other projects, including NIH-funded research, in order to focus entirely on this substance.
The product, MGN-3 (an
arabinoxylane compound), is a polysaccharide composed of the hemicellose-J3 extract of rice bran,
modified by enzymes from Shiitake mushrooms. As we have detailed in 7 previously published studies, involving a total of 72 human subjects, the efficacy ofMGN-3 equals or surpasses the very best immune-modulating drugs available but, in stark contrast to these, exhibits a complete lack of toxicity. (Copies of complete research papers and data on MGN-3 can be obtained from Lane Labs at 201-236-9090,)
Much of the data regarding MGN-3 has been previously published in technical journals and presented at international research conferences, but the information remains largely unknown to oncologists and other health professionals dealing directly with the cancer patient. The aim of this article is to bring this research to the attention of the practicing clinician, to summarize what is known about the actions of MGN-3, and explore its present role in the treatment of cancer patients.
Anti-viral activity: In addition to very encouraging results using MGN-3 in the treatment of malignancies, other research suggests a promising role for MGN-3 as a therapy for HIV, Hepatitis C, and other viral infections. MGN-3 has antiviral activity and also enhances the

body's immune response against virally­infected cells. In vitro research shows that MGN-3 inhibits replication of the HIV virus without cytotoxicity in a dose­dependent manner.' Human studies suggest that MGN -3 may also be extremely useful in the treatment of Hepatitis C. In these patients liver enzymes return to normal levels within 1-8 weeks of treatment with MGN-3. The results of our ongoing clinical research into the antiviral applications of MGN-3 will be the subject of future reports.
The role of NK cells in the treatment of cancer
Over 150 different types of white blood cells have been identified and, of these, NK cells are one of the most common, representing up to 15% oftotal white blood cells. They are important because, unlike other white blood cells, they are able to work more or less independently, not requiring special instructions from the immune system in order to recognize or attack a foreign cell. For this reason, they are often considered to be the body's first line of defense against cancer and viral­infected cells.
Photo #1:
NK cell (top) attaching to a cancer cell.
Photo #2:
The cancer cell is dissolved and the NK cell moves on to another cancer cell.
TOWNSEND LETTER for DOCTORS & PATIENTS - JANUARY 2000
/

One Sizeable Step for Immunology, One Giant Leap for Cancer Patients
by Mamdooh Ghoneum, PhD
Associate Professor and Chief of Research, Department of Otolaryngology, Charles D. Drew University; Research Associate, Department of Neurobiology, UCLA School of Medicine
Background
Although cymclsm and dis­illusionment with the failed "war against cancer" are widespread, I remain very optimistic that we will triumph over this seemingly invincible killer. Given the disappointing results and many drawbacks of cytotoxic therapies, it seems clear that our best hope for a decisive victory against cancer liesin immuno-augmentive therapies ­those that enhance the body's innate immune response to cancer cells.
As a research immunologist, I have spent 18 years studying immuno­modulating substances - natural compounds derived from mushrooms, herbs, fungi, and bacteria, as well as synthetic drugs like Interleukin-2 and interferon. Approximately six years ago, I stumbled across a natural substance that was so promising, so profoundly superior to everything else I had ever evaluated, that I abandoned all other projects, including NIH-funded research, in order to focus entirely on this substance.
The product, MGN-3 (an
arabinoxylane compound), is a polysaccharide composed of the hemicellose-J3 extract of rice bran,
modified by enzymes from Shiitake mushrooms. As we have detailed in 7 previously published studies, involving a total of 72 human subjects, the efficacy ofMGN-3 equals or surpasses the very best immune-modulating drugs available but, in stark contrast to these, exhibits a complete lack of toxicity. (Copies of complete research papers and data on MGN-3 can be obtained from Lane Labs at 201-236-9090.)
Much ofthe data regarding MGN-3 has been previously published in technical journals and presented at international research conferences, but the information remains largely unknown to oncologists and other health professionals dealing directly with the cancer patient. The aim ofthis article is to bring this research to the attention of the practicing clinician, to summarize what is known about the actions of MGN-3, and explore its present role in the treatment of cancer patients.
Anti-viral activity: In addition to very encouraging results using MGN-3 in the treatment of malignancies, other research suggests a promising role for MGN-3 as a therapy for HIV, Hepatitis C, and other viral infections. MGN-3 has antiviral activity and also enhances the

body's immune response against virally­infected cells. In vitro research shows that MGN-3 inhibits replication of the HIV virus without cytotoxicity in a dose­dependent manner.' Human studies suggest that MGN-3 may also be extremely useful in the treatment of Hepatitis C. In these patients liver enzymes return to normal levels within 1-8 weeks of treatment with MGN-3. The results of our ongoing clinical research into the antiviral applications of MGN-3 will be the subject offuture reports.
The role of NK cells in the treatment of cancer
Over 150 different types of white blood cells have been identified and, of these, NK cells are one of the most common, representing up to 15% oftotal white blood cells. They are important because, unlike other white blood cells, they are able to work more or less independently, not requiring special instructions from the immune system in order to recognize or attack a foreign cell. For this reason, they are often considered to be the body's first line of defense against cancer and viral­infected cells.
Photo #1:
NK cell (top) attaching to a cancer cell.
Photo #2:
The cancer cell is dissolved and the NK cell moves on to another cancer cell.
TOWNSEND LETTER for DOCTORS & PATIENTS - JANUARY 2000
/

Circulating through the body by way of the blood and lymph systems, the majority ofNK cells present in the body are in a resting state. NK cells become more active in response to immunoregulatory proteins called cytokines. Once activated, the NK cells become quite rapacious in their search­and-destroy activities. Upon encountering a tumor cell, the activated NK cell attaches to the membrane ofthe cancer cell and injects cytoplasmic granules that quickly dissolve (lyse) the target cell. In less than five minutes, the cancer cell is dead and the NK moves on to its next victim. A single NK cell can destroy up to 27 cancer cells before it dies. Although quite small in comparison to tumor or virus cells, a single NK cell can often bind to two or more cancer cells at once.
The absolute number of NK cells present in the blood gives little indication of the efficiency of immune function. Instead, it is the activity ofthe NK cells - the avidity with which they recognize and bind to tumor cells - that is important. Most immuno-modulators, including MGN-3, do not increase the number or percentage of NK cells, but instead increase their level of activation. NK cell activity can be tested by means of a 4-hour radioactive-Chromium release assay. NK cells are isolated from a blood sample and are incubated in

vitro with a fixed number of chromium­labeled tumor cells. After 4 hours, the percentage of tumor cells that have been killed by the NK cells is determined, and this percentage can be used to describe NK cell activity.
In a healthy immuno-competent individual, when NK cell activity is examined at an effector:target ratio of 100:1, we would expect to see NK cell activity ranging from 60-75%. However, in cancer patients, NK cell activity typically ranges from near 0% to 30%. Although it is not entirely clear whether this is a cause or result of the disease process, there is evidence suggesting that low NK cell activity may be a risk factor for malignancy or metastases, as well as a negative prognostic indicator.' Therefore, agents that stimulate NK cell function are being sought as possible cancer therapeutic agents.
Proven human efficacy. We have previously presented data on 32 cancer patients, with different types of advanced malignancies.3.5 These patients had received and completed conventional therapy such as surgery, chemotherapy, radiation or hormonal therapy prior to participation in the study. The baseline NK cell activity was found to be low in all patients (10.8­49%). Oral ingestion ofMGN-3 at 45 mg! kg/day led to a significant increase in NK cell activity after only 1-2 weeks.

Cancer Immunology
The increase in baseline NK cell activity after two weeks of administration ranged from 145%-332% in breast cancer patients, 174%-385% in prostate cancer patients, 100%-240% in leukemia patients, and 100%-537% in multiple myeloma patients.
Longevity of response: One ofthe great and constant frustrations of the immunologist is the phenomenon of hyporesponsiveness. Science has identified many biological response modifiers (BRMs) that can substantially increase NK cell activity. However, the effect frequently attenuates over time, despite continued administration of the immunomodulator." One ofthe most exciting and distinguishing charac­teristics ofMGN-3 is that it appears to maintain its immunomodulatory effect over time. In long-term follow-up of our I patients (up to 5 years), we have observed that the enhancing effect of MGN-3 on NK cell activity is maintained indefinitely with continued administration.
Lack of toxicity: Another disappointment regarding synthetic immune boosters such as IL-2 and interferon is that these therapies, while variously effective in boosting the immune response against tumors and viruses, are exceedingly toxic and accompanied by numerous side effects, the most serious of which is kidney failure. By contrast, MGN-3 appears to be exceptionally non-toxic and well­tolerated.
In acute oral toxicity trials in rats, MGN-3 was found to be without toxic effects at dosages up to 36 g/kg. In addition, human trials using up to 45mg!


MGN-3
IL-2
MGN-3 + IL-2
TOWNSEND LETTER for DOCTORS & PATIENTS - JANUARY 2000


Cancer Immunology
>
kg/day of MGN-3 for six months have noted no abnormalities in blood chemistry or liver enzymes (SGOT and SGPT).'
Moreover, in 4 years of use with hundreds of patients, we have had no reports of side effects or interactions of any kind. In fact, our clinical experience suggests that MGN-3 can be safely and advantageously used in conjunction with conveptional treatment, including chemotherapy and radiation, both to increase the cytotoxic effect of the therapy and to decrease adverse side effects.
Clinical results: Enhanced
immune function is, however, only a theoretical victory if it does not lead to clinical improvement. But in fact, the documented increase in NK cell activity in cancer patients taking MGN-3 has been correlated to dramatic reductions in corresponding tumor markers and other pathology indicators, and, most importantly, to long-term stabilization or remission of disease in the large majority of cases (>85%). The complete clinical data for a total of 106 patients treated since 1995, including hematology and pathology reports, as well as incidence of remission and length of survival, are in the process of being collected and analyzed. It can be stated, however, that very few have been lost to follow up and virtually all continue to be in good health.
Discussion
Mechanisms of action: In addition to direct cytotoxic activity against tumor cells, activated NK cells also produce a variety of cytokines, including the interferons, interleukins, tumor necrotic factors and other growth factors. These cytokines, in turn, have direct antiviral and anti-cancer activities, as well as further immunomodulatory effects, such as upregulation of T- and B- cells, and further activation of NK cells. Our research suggests that MGN-3 works by simulating the body's natural production of interferon-y and tumor­necrosis factor-a.s These chemicals not only have direct anti-tumor activity themselves, but also directly and indirectly activate NK cell, B-cell and T-cells.
Synthetic cytokines interleukin-2 (IL-2), interferon-gamma (IFN-8) and tumor necrosis factor-alpha (TNF-a) have all been investigated as possible cancer-therapeutic agents, and have shown varying success. The most success has been seen with interleukin­2; however, the dosages needed to achieve positive results are associated with extreme toxicity.
MGN-3 may offer a novel solution to this dilemma. In vitro studies suggest that MGN-3 used in combination with low levels of IL-2 may significantly potentize the effect of IL-2. Figure 1 shows the effect on NK cell activity of
100

1 month Time after treatment
2 months
TOWNSEND LETTER for DOCTORS & PATIENTS - JANUARY 2000
MGN-3 and low doses ofIL-2, separately and in combination. The combined, synergistic effect of the two substances is significantly greater than either alone. This suggests that the immunomodulatory effect of low concentrations ofIL-2 on NK cell activity could be greatly augmented with the adjuvant use ofMGN-3.'
Clinical applications: Conven­tional medicine has excellent anti-tumor therapies that can significantly reduce the number of cancer cells. Unfortunately, we have seen that it is difficult to achieve a 100% kill rate without killing the patient in the process. At best, we can hope to kill 95­98% of the cancer cells with these therapies. At this point, a patient may be considered to be "in remission." Therapy is discontinued and the patient is closely monitored. However, as most oncologists are painfully aware, these remissions are frequently short-lived.
Most cytotoxic therapies are themselves immunosuppressive, lowering the activity of anti-cancer effector cells. Following chemotherapy or radiation, the few hardy cancer cells that survive the therapy are left to replicate largely unchallenged by a damaged immune system. When the cancer eventually resurfaces, it does so with increased ferocity and often with increased drug resistance.
In my opinion, the practice of watchful waiting wastes a golden opportunity to administer the coup de grace. At the very early stages of detection, or, in more advanced stages, when the tumor-load has been Feduced as far as possible by surgery and/or conservative cytotoxic therapies, boosting the immune system with biological response modifiers allows the body to eradicate the remaining cells that have escaped the chemicals, radiation, or surgeon.
However, MGN-3 cannot and should not replace debulking therapy, especially in the case of advanced malignancies. In these cases, even an extremely active immune response is easily overwhelmed by the huge numbers of cancer cells present. Instead, we recommend that cancer patients with solid tumors begin MGN-3 immunotherapy concurrent with or immediately following debulking
'.
!

Cancer Immunology
therapies. With this strategy we have the best chance of winning what essentially becomes a war of numbers.
In addition, we have found that cancers of the blood, such as leukemia and multiple myeloma, have been particularly responsive to MGN-3 therapy, presumably because the activated natural killer cells have even better access to these cancer cells than to those forming solid tumors.
MGN-3 can also be used to advantage as a preventive in high-risk populations. Unfortunately, the realities of our high-stress modern lifestyle, which include increasing exposure to mutagenic environmental toxins, the numbers of people who might be considered 'high-risk' are increasing. In one particularly disturbing study, researchers found persistently depressed NK cell activity in 14% of 'healthy' young adults.'o
Dosage considerations: As figure 2 illustrates, MGN-3 at 30 mglkg/day caused a steep (310%) increase in NK cell activity after only one week. NK cell activity continued to increase at a slower rate, to a peak activity of 500% over baseline by week 8 of this particular study, which involved 24 healthy subjects." This study also illustrates the interesting dose-dependent nature ofMGN-3. Lower doses (15 mglkg/day) yield a much slower initial increase, however all dosage levels achieve maximum activity by week 8. Within one month of cessation of treatment, NK cell activity returned to baseline. Clinical experience indicates that once maximum levels ofNK cell activity have been attained, they can in most <{ases be maintained indefinitely at the lower dosage level of 15 mglkg/day.
In the fight against cancer, time is of the essence. At the very early stages or immediately following debulking therapy, the numbers of cancer cells are relatively low and more susceptible to eradication by an aggressive immune system. Therefore, it is important to increase NK cell activity as quickly as possible in these patients. For these reasons, we recommend a loading dose of 30-45 mglkg/day for cancer patients. After two to three months, the dosage may be reduced to 15 mg/kg/day. In some individuals, the higher dose needs to be continued for a longer period of time.
Sustained clinical improvement (for example, normal tumor markers and negative imaging) is an indication that dosages can safely be reduced to a maintenance level. For general prevention, 15mg/kg/day is appropriate. The product is typically administered in 2-3 divided doses, accompanied by a meal.
Conclusion
Those involved with alternative and holistic medicine may be tempted to dismiss the introduction of yet another natural "immune booster" as hype. Many products are promoted to cancer patients on the strength of "scientific proof" of enhanced immune function. In most cases, however, the only research has been conducted in test tubes, or at most, in animals. But as many have noted, most recently apropos the work of Dr. Judah Folkman, if curing cancer in mice were equivalent to curing cancer in humans, this dread disease would already be a relic of a bygone era, rather than accompanying us into the new millennium.
Unlike most natural preparations, MGN-3 offers solid data collected from human clinical trials. This data offers compelling evidence that MGN-3 is a powerful biological response modifier that is free of toxicity or side effects. As such, it has enormous promise as an immunotherapy in the treatment of cancer and other diseases.
Correspondence:
Mamdooh Ghoneum, PhD Charles D. Drew University of Medicine and Science Department of Otolaryngology 1621 East 120th Street
Los Angeles, CA 90059 USA 323-563-5953
Fax 310-668-4554
References
Ghoneum, M, Anti-HIV activity in vitro of MGN-3, an activated Arabinoxylane from rice bran, Biochemical Research Communi­cations 1998, 243:25-29.
Whiteside T, Herberman, R, Human Natural Killer Cells in Health and Disease, Clinical Immuno­therapeutics 1994, 1(1):56-66.
Ghoneum, M, Manatalla, G, NK immunomodulatory function in 27 p2.tients by MGN-3, a modified ara­binoxylane from rice bran, Abstract, 87th Annual Meeting of the American Association for Cancer Research, April, 1996, Washington, DC.
Ghoneum, M, Immunomodulatory and Anti-cancer properties of MGN-3, a modified xylose from rice bran, in 5 patients with breast cancer, Abstract, American Association for Cancer Research Special Conference:
The Interface between basic and applied research. November, 1995, Baltimore, MD.
Ghoneum, M, NK
Immunorestoration of Cancer Patients by MGN-3, a modified arabinoxylane rice bran (study of 32 patients up to 4 years), Abstract, 6th International Congress on Anti­Aging and Bio-medical Technologies (American Academy of Anti-aging Medicine), December, 1998, Las Vegas, Nevada.
Sait 0, Ruffman R, Development of hyporesponsiveness of natural killer cells to augmentation of activity after multiple treatments with biological response modifiers, Cancer Immunol Immunother 1985;19: 130-135.
Ghoneum M, Enhancement of Human Natural Killer Cell Activity by modified Arabinooxylane from rice bran, Int. J Immunotherapy 1998; 14(2):89-99.
Ghoneum M, Effect of MGN-3 on Human natural killer cell activity and interferon-y synthesis in vitro, FASEB 1996, 10(6):26-32.
Manuscript in preparation 10.Levy SM, Persistently low natural killer cell activity in normal adults, Nat Immun Cell Growth Regul1989; 8:173-86.
l1.0p cit. #7.
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coolhandluke74

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11/08/2008 05:17 AM
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Re: For coolhandluke74 or others interested in cancer help
Ty friend, i have heard much on the baking soda and maple syrup cure.
Anonymous Coward (OP)
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11/08/2008 06:06 AM
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Re: For coolhandluke74 or others interested in cancer help
Ty friend, i have heard much on the baking soda and maple syrup cure.
 Quoting: coolhandluke74

You're welcome. I had a friend who developed colon cancer. I told him about MGN3. He took the information to his doctor who gave him the green light and he was taking it for several years. His cancer was in complete remission. I lost touch with him and later learned through a mutual friend that he had stopped taking the MGN3 and his cancer returned and he succumbed in less than a year. It's worth looking into IMO
Anonymous Coward
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11/08/2008 06:28 AM
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Re: For coolhandluke74 or others interested in cancer help
bump to check out later





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