Sorry - i dont know about a train wreck - will check some sources.


But what I found here, made me just p.ss my pants:

[link to www.thelancet.com]

You need to pay for the full story:

The Lancet, Early Online Publication, 31 October 2009

Importance of background rates of disease in assessment of vaccine safety during mass immunisation with pandemic H1N1 influenza vaccines

Original Text
Prof Steven Black MD a Corresponding AuthorEmail Address, Prof Juhani Eskola MD b, Prof Claire-Anne Siegrist MD c, Prof Neal Halsey MD d, Prof Noni MacDonald MD e, Prof Barbara Law MD f, Elizabeth Miller FRCPath g, Nick Andrews MSc g, Julia Stowe BA g, Daniel Salmon PhD h, Kirsten Vannice MHS h, Hector S Izurieta MD i, Aysha Akhtar MD i, Prof Mike Gold MD j, Prof Gabriel Oselka MD k, Patrick Zuber MD l, Dina Pfeifer MD l, Claudia Vellozzi MD m

Summary
Because of the advent of a new influenza A H1N1 strain, many countries have begun mass immunisation programmes. Awareness of the background rates of possible adverse events will be a crucial part of assessment of possible vaccine safety concerns and will help to separate legitimate safety concerns from events that are temporally associated with but not caused by vaccination. We identified background rates of selected medical events for several countries. Rates of disease events varied by age, sex, method of ascertainment, and geography. Highly visible health conditions, such as Guillain-Barré syndrome, spontaneous abortion, or even death, will occur in coincident temporal association with novel influenza vaccination. On the basis of the reviewed data, if a cohort of 10 million individuals was vaccinated in the UK, 21·5 cases of Guillain-Barré syndrome and 5·75 cases of sudden death would be expected to occur within 6 weeks of vaccination as coincident background cases. In female vaccinees in the USA, 86·3 cases of optic neuritis per 10 million population would be expected within 6 weeks of vaccination. 397 per 1 million vaccinated pregnant women would be predicted to have a spontaneous abortion within 1 day of vaccination.


As they allways say.: "That's not tooooooo bad" or "No problemo - within the limits"