In the science fiction television show Stargate SG-1, Stargate Command (also known as the SGC), is located in the Cheyenne Mountain complex in Colorado. It houses the Stargate through which SG teams are sent to other worlds

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Today, Cheyenne Mountain is known as Cheyenne Mountain Air Force Station (CMAFS). CMAFS is host to four commands: North American Aerospace Defense Command (NORAD), United States Northern Command (USNORTHCOM), United States Strategic Command (USSTRATCOM), and Air Force Space Command (AFSPC). CMOC serves as the command center for both NORAD and USNORTHCOM. It is the central collection and coordination center for a worldwide system of satellites, radars, and sensors that provide early warning of any missile, air, or space threat to North America.

Supporting the NORAD mission, CMOC provides warning of ballistic missile or air attacks against North America, assists the air sovereignty mission for the U.S. and Canada, and if necessary, serves as the focal point for air defense operations to counter enemy bombers or cruise missiles. In addition, CMOC also provides theater ballistic missile warning for U.S. and allied forces. In support of USSTRATCOM, CMOC provides a day-to-day picture of precisely what is in space and where it is located. Space control operations include protection, prevention, and negation functions supported by the surveillance of space.

CMOC is truly one of the most unusual installations in the world. Apart from the fact that it is housed 2,000 feet (600 m) underground, CMOC is also different from most military units because it is a joint and bi-national military organization comprised of over 200 professional men and women from the Army, Navy, Marine, Air Force, and Canadian Forces. Operations are conducted in seven centers manned 24 hours a day, 365 days a year. The centers are the Air Warning Center, Missile Warning Center, Space Control Center, Operational Intelligence Watch, Systems Center, Weather Center, and the Command Center.

In fiction
In the television series Stargate SG-1, Cheyenne Mountain is home to the fictional Stargate Command and houses a stargate under the control of the American government. It is the primary base of operations for the characters of the series.

In the television series "Jeremiah", Cheyenne Mountain has become Thunder Mountain, the primary post-apocalyptic community of the show.