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Message Subject X Marks the Spot
Poster Handle Anonymous Coward
Post Content
and what is happiness if not misery rendered

 Quoting: Azeratel Axo


Can one know pleasure without pain?


...


Love this, pi.


Pain causes movement, and reflection...

:IntotheDarkenss:
 Quoting: Seer777

 Quoting: Seer777


Pain causes one of two effects. More pain or deformation of cyclical conciousness and a new way of doing things.

All the love in the world does nothing without pain.

As pain (need to move or repeat) is the reason for movement.

No whimsical wants but deeply tied needs.

Tied being the operative in the operator.
 Quoting: Anonymous Coward 31036731


Ahh yes

Which is why we love opiates so much

Those of us that do anyways

Simultaneous activation of pain (Kappa) and 'pleasure' (or 'forward'/Mu) receptors

Opioids without pain induction (kappa agonism) lose their dependence liability, but shockingly, not the addictive aspect.

Certain frog venoms are loaded with Mu-specific proteins, about 10,000x the potency of morphine if memory serves.

If specificity is further enhanced, by going to just Mu1 receptor activation, the opioids additionally lose their lethality.

As to why these are not medicines yet? Anyone's guess.
 Quoting: Azeratel Axo


Who wants to get rid of pain? In the question is the answer.
 
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