A 14-year-old girl has died after being given a cervical cancer jab as part of a national immunisation programme, but the exact cause of death is unknown.
The pupil took ill at Blue Coat CofE School in Coventry shortly after she received the Cervarix vaccine. She died in the town's University Hospital.
The batch of the vaccine used has been quarantined by the local NHS.
The injection offers protection against a sexually transmitted disease, which is linked to most cervical cancers.
A routine programme of vaccinating 12- and 13-year-old girls started in September 2008 across the UK using the Cervarix vaccine made by GlaxoSmithKline. A catch-up campaign is now under way for older girls.
The injection offers protection against the human papilloma virus (HPV), the most common cause of cervical cancer.
'Urgent investigation'
The girl, who has not yet been named, died at lunchtime on Monday.
Dr Caron Grainger, joint director of public health for NHS Coventry and Coventry City Council, said their sympathies are with the girl's family and friends.
She said: "The incident happened shortly after the girl had received her HPV vaccine in the school. No link can be made between the death and the vaccine until all the facts are known and a post-mortem takes place.
"We are conducting an urgent and full investigation into the events surrounding this tragedy."
A small number of girls at the school had also reported mild symptoms such as dizziness and nausea but they were not admitted to hospital.
In a statement posted on the school's website, headteacher Dr Julie Roberts said during the immunisation, "one of the girls suffered a rare, but extreme reaction to the vaccine".
"A number of other girls also reported being unwell and some were sent home," she said.
"If your daughter has received a vaccine today we ask that you are extra vigilant regarding any signs or symptoms."
She listed possible reactions as mild to moderate short-lasting pain at the injection site, headache, muscle pain, fatigue and a low-grade fever.
'Tragic death'
It is thought about a million girls have already safely received the vaccine.
When the national immunisation project was announced, there was some controversy about the selection of Cervarix over Gardasil, which is used by the majority of vaccination programmes worldwide.
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