In North America, this is the BIG doom that
I feel is most likely.

If I lived between Northern California and Vancouver Island
Canada, I would have a mountain bike with all the luggage
carrying capacity I could bolt on to it.
And I would load it with all the stuff needed to
bicycle my way out of the area.
West is the only direction to go, so I would plan a route
to the west.
The damage this earthquake will do to Portland and
Seattle and surrounding areas is unimaginable.