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Possible drug and/or health conditions interactions with Ivermectin. Link --- Please help with more info.

 
Anonymous Coward
User ID: 35913160
United States
12/30/2020 12:12 PM
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Possible drug and/or health conditions interactions with Ivermectin. Link --- Please help with more info.
If a person was considering taking oral Ivermectin, what warning would a competent honest doctor give?

Just wondering.

Here is a start...

[link to www.bing.com (secure)]

"Stromectol
Generic Name: Ivermectin
OVERVIEW
SIDE EFFECTS
INTERACTIONS
DOSAGE
Interactions
Before taking this medication, tell your doctor if you've had:

Liver problems
Products that may interact with this drug include:

Barbiturates (such as phenobarbital, butalbital)
Benzodiazepines (such as clonazepam, lorazepam)
Sodium oxybate (GHB)
Valproic acid
Warnings
Medication should be taken with plenty of water.
May cause dizziness"
Anonymous Coward (OP)
User ID: 35913160
United States
12/30/2020 12:35 PM
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Re: Possible drug and/or health conditions interactions with Ivermectin. Link --- Please help with more info.
"“Is ivermectin safe and are there any contraindications for use?”
The discovery of Ivermectin in 1975 was awarded the 2015 Nobel Prize in Medicine given its global
impact in reducing onchocerciasis (river blindness), lymphatic filiariasis, and scabies in endemic areas of
central Africa, Latin America, India and Southeast Asia. It has since been included on the WHO’s “List of
Essential Medicines with now over 4 billion doses administered. Numerous studies report low rates of
adverse events, with the majority mild, transient, and largely attributed to the body’s inflammatory
response to the death of parasites and include itching, rash, swollen lymph nodes, joint paints, fever
and headache. In a study which combined results from trials including over 50,000 patients, serious
events occurred in less than 1% and largely associated with administration in Loa Loa infected patients.
Further, according to the pharmaceutical reference standard Lexicomp, the only medications contraindicated for use with ivermectin are the concurrent administration of anti-tuberculosis and cholera
vaccines while the anticoagulant warfarin would require dose monitoring. Another special caution is
that immunosuppressed or organ transplant patients who are on calcineurin inhibitors such as tacrolimus or cyclosporine or the immunosuppressant sirolimus should have close monitoring of drug levels
when on ivermectin given that interactions exist which can affect these levels. A longer list of drug
interactions can be found on the database of [link to www.drugs.com (secure)] with nearly all
interactions leading to a possibility of either increased or decreased blood levels of ivermectin. Given
studies showing tolerance and lack of adverse effects in human subjects given even escalating, high
doses of ivermectin, toxicity is unlikely although a reduced efficacy due to decreased levels may be a
concern. Finally, ivermectin has been used safely in pregnant women, children, and infants."

Less than 50%

[link to covid19criticalcare.com (secure)]
Anonymous Coward (OP)
User ID: 35913160
United States
12/30/2020 09:49 PM
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Re: Possible drug and/or health conditions interactions with Ivermectin. Link --- Please help with more info.
bump
Anonymous Coward
User ID: 72669706
United States
12/30/2020 10:34 PM
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Re: Possible drug and/or health conditions interactions with Ivermectin. Link --- Please help with more info.
Thanks
Anonymous Coward
User ID: 76392954
Canada
12/30/2020 11:32 PM
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Re: Possible drug and/or health conditions interactions with Ivermectin. Link --- Please help with more info.
I see what you did there opie.

Sly yet clever.
Anonymous Coward
User ID: 16135405
United States
12/31/2020 01:12 AM
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Re: Possible drug and/or health conditions interactions with Ivermectin. Link --- Please help with more info.
bump
Anonymous Coward
User ID: 75958720
Canada
12/31/2020 01:14 AM
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Re: Possible drug and/or health conditions interactions with Ivermectin. Link --- Please help with more info.
Sounds good to go
Anonymous Coward (OP)
User ID: 35913160
United States
12/31/2020 07:46 PM
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Re: Possible drug and/or health conditions interactions with Ivermectin. Link --- Please help with more info.
"“Is ivermectin safe and are there any contraindications for use?”
The discovery of Ivermectin in 1975 was awarded the 2015 Nobel Prize in Medicine given its global
impact in reducing onchocerciasis (river blindness), lymphatic filiariasis, and scabies in endemic areas of
central Africa, Latin America, India and Southeast Asia. It has since been included on the WHO’s “List of
Essential Medicines with now over 4 billion doses administered. Numerous studies report low rates of
adverse events, with the majority mild, transient, and largely attributed to the body’s inflammatory
response to the death of parasites and include itching, rash, swollen lymph nodes, joint paints, fever
and headache. In a study which combined results from trials including over 50,000 patients, serious
events occurred in less than 1% and largely associated with administration in Loa Loa infected patients.
Further, according to the pharmaceutical reference standard Lexicomp, the only medications contraindicated for use with ivermectin are the concurrent administration of anti-tuberculosis and cholera
vaccines while the anticoagulant warfarin would require dose monitoring. Another special caution is
that immunosuppressed or organ transplant patients who are on calcineurin inhibitors such as tacrolimus or cyclosporine or the immunosuppressant sirolimus should have close monitoring of drug levels
when on ivermectin given that interactions exist which can affect these levels. A longer list of drug
interactions can be found on the database of [link to www.drugs.com (secure)] with nearly all
interactions leading to a possibility of either increased or decreased blood levels of ivermectin. Given
studies showing tolerance and lack of adverse effects in human subjects given even escalating, high
doses of ivermectin, toxicity is unlikely although a reduced efficacy due to decreased levels may be a
concern. Finally, ivermectin has been used safely in pregnant women, children, and infants."

Less than 50%

[link to covid19criticalcare.com (secure)]
 Quoting: Anonymous Coward 35913160
Anonymous Coward (OP)
User ID: 35913160
United States
08/04/2021 11:35 AM
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Re: Possible drug and/or health conditions interactions with Ivermectin. Link --- Please help with more info.
bump





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