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H1N1 Attack Rate Explodes In Ukraine
Recombinomics Commentary 16:29
November 1, 2009

In the Lviv region at 9.00 am on November 1 the number of deaths due to epidemics of influenza and SARS is 23 people. Of these, two children under 14 years old and 21 adults.

It is reported by the official web portal of the Lviv regional state administration.

According to official figures, the number of patients with influenza and SARS in the Lviv region is 78 thousand 102 persons (including children under the age of 14 - 38 thousand 450 adults - 39 thousand 652).

The number of hospitalized - 1 thousand 799 persons (including children under the age of 14 - 639, adults - 1 thousand 160).

In general, the incidence rate in the area is 312.4 per 10 thousand people (with children under 14 years - 967.8 per 10 thousand population).

The above translation describes the latest data on the H1N1 outbreak in the Ukraine. The updated government website has 53 fatalities (see updated map) and breaks down cases by region, including data for influenza and acute respiratory illness (see table here). The number of fatalities suggests that most ARI cases are swine flu, because in some instances the number of fatalities is between 0.5 and 1% of listed influenza cases. The ARI cases are 10-20 fold higher, which would significantly lower the Case Fatality Rate (CFR), but even with the listed ARI cases, the CFR would be alarmingly high. Thus, the number of ARI cases may be higher, or the virus is producing a significantly higher CFR.

However, as seen above, the incidence level in children has reached an alarming high rate of 10% in those under 14. If true, this rate would indicate the virus is spreading rapidly and raise additional concerns that the virus has changed and has a very high attack rate.

Thus, the data is still quite fluid, and information on the sequence of the virus is critical. Prompt release of these sequences would be useful.

you know the more i look at this the more i am convinced that what we are seeing in indias h1n1 and this corona virus is linked the increasing mortality rate , and virulence are ringing bells , the ukraine incident is part of the larger picture

[link to preventdisease.com]

[link to www.riskinstitute.org (secure)]

we are searching for a super carrier

[link to lib.bioinfo.pl]

Human parainfluenza virus 3 (HPIV-3) is a leading cause of respiratory disease in children worldwide. Previous sequence analyses of the entire virus genome, among different HPIV-3 strains, demonstrated that HN is the most variable gene. There is a dearth of data on HPIV-3 strains circulating in Saudi Arabia. In this report, HPIV-3 was screened in nasopharyngeal aspirates collected from hospitalized children with acute respiratory disease during two successive seasons (2007/08 and 2008/09) using nested RT-PCR. Out of 73 samples collected during 2007/08, seven (9.59%) were positive; while 3 out of 107 samples collected during 2008/09 (2.8%) were positive. Virus isolation in cell culture was successful using HEp2, but not Vero cells. The identity of the isolated viruses was confirmed using immunofluorescence and neutralization assays. To elucidate the genetic characteristics and phylogeny of Saudi HPIV-3 strains, the complete HN gene sequence of two selected Saudi strains was analyzed in comparison to 20 strains isolated by others from different countries worldwide. Both strains showed the highest degree of sequence homology with Indian strains, followed by Chinese and most Japanese strains. Phylogenetic analysis confirmed that these strains fell into a distinct Asian lineage. This study is the first in Saudi Arabia to recover HPIV-3 isolates of confirmed identity, and to generate sequence data that may help in understanding virus diversity and evolution. J. Med. Virol. 84: 1304-1311, 2012. © 2012 Wiley Periodicals, Inc.

[link to www.ncbi.nlm.nih.gov]

[link to www.flutrackers.com]

[link to thebirdflupandemic.com]

RBD Change D225G in Ukraine Lungs Raises Concerns
Recombinomics Commentary 21:53
November 18, 2009

Mill Hill, a WHO regional center in London has placed sequences from 10 isolates from Ukraine (see map) on deposit at GISAID (see list below). They are to be commended for the prompt deposit of these important sequences. The availability of the sequences should put an end to wild speculation on the origins of the Ukraine outbreak.

All H and N sequences are typical for H1N1, as indicated in early WHO announcements. There are no large changes. Additional gene segments have been deposited from a subset of these isolates (but not analyzed below). There are silent changes that are in all or most Ukraine sequences, but the only HA polymorphism was the receptor binding domain change, D225G. This polymorphism was in the three lung, as well as the one throat sample. It was not in the nasopharyngeal washes or the isolate grown in MDCK cells suggesting the D225G may have a tissue tropism component and may allow for high levels of virus in the lung.

D225G was also found in necropsy lung tissue from fatal cases in Sao Paulo, further supporting tissue tropism associated with this polymorphism. The polymorphism has recently appeared on a series of different genetic backgrounds, supporting acquisition by recombination. The genetic backgrounds were geographically diverse. It was appended onto a genetic background specific for China as well as another distinct background found in Singapore and Japan. It has also recently appeared on backgrounds from Spain and Brazil. In addition, it was in isolates from last spring collected in the United States and Mexico.

The appearance of D225G on multiple recent genetic backgrounds raises concerns that the polymorphism is offering a selective advantage in association with multiple genetic backgrounds, and the selective detection of the polymorphism in lung and throat samples may indicate it is more widespread because of its absence from nasopharyngeal washes. Lung and throat sampling may be required for detection and determination of the true geograpohical reach of this change..

More information on outcomes for these patients, as well as results for lung and nasopharyngeal samples from the same patient, would be useful.

The prompt release of these sequences should help guide further analysis of the evolving swine H1N1.

A/Khmelnitsky/1/2009 EPI_ISL_62017
A/Ternopil/19/2009 EPI_ISL_62016
A/Ternopil/11/2009 EPI_ISL_62015
A/Ternopil/6/2009 EPI_ISL_62014
A/Ternopil/5/2009 EPI_ISL_62013
A/Lviv/N6/2009* EPI_ISL_62012
A/Ternopil/N11/2009* EPI_ISL_62011
A/Ternopil/N10/2009* EPI_ISL_62010
A/Lviv/N2/2009* EPI_ISL_62009
A/Kyiv/N1/2009 EPI_ISL_62008

RBD D225G in China and Australia Raise Ukraine Concerns
Recombinomics Commentary 14:41
November 18, 2009

The recent outbreak in Ukraine has raised concern that receptor binding domain changes are responsible. Although WHO has issued a new Ukraine situation update and has addressed preliminary changes in a news conference, they have not rule out receptor binding domain changes, and the recent announcement of investigations by two WHO Regional Centers (NIMR in Mill Hill, UK and CDC in Atlanta GA) suggests single nucleotide changes are under investigation.

One such change is the receptor binding domain polymorphism D225G which is present on recently released sequences from China and Australia. The HA sequence from China, A/Zheijiang/DTID-ZJU03/2009, is virtually identical to two earlier sequences from Yiwu (A/Zhejiang/DTID-ZJU02/2009 and A/Zhejiang-Yiwu/11/2009) and all were collected in September and appear to be from the same patient or contacts. The patient eventually recovered, but was seriously ill and hospitalized for several weeks. However, the three sequences from Yiwu match (see list here) sequences from an isolate, A/Hangzhou/1/2009, that is in another location in Zheijiang (see map), indicating D225G was appended onto the Hangzhou genetic background via recombination.

A sequence released Monday at GISAID by the WHO regional center in Australia, A/Sydney/2503/2009, also has D225G, but on a different genetic backbone. The 5' end of the gene matches isolates from Singapore and Japan (see list), which do not have D225G. Thus, D225G is appended onto this background via recombination, but the background in Australia is distinct from the background in China.

Similarly, the two genetic backbones described above are distinct for two isolates in Sao Paulo, which were from fatal cases. The lung isolates signal the jumping of D225G from one genetic backbone to another. This concurrent acquisition has been described in H5N1, as well as the genetic hitchhiking of H274Y in seasonal H1N1.

This jumping of the same polymorphisms form one background to another signals major changes, especially when the polymorphism "in play" is a receptor binding domain change, which is cause for concern.

The recent activity in Ukraine raises concerns that similar changes are in play there, and the failure of WHO to release the sequences or comment on receptor binding domain changes significantly increases these concerns.

[link to www.recombinomics.com]

Aside from that I would love to know what your IQ is, I will bet its over 140.

Tell me if Im right!

now what would give you that idea ?....I have absolutely no idea , I image it would be on the lower end of the scale , but if you take an honest look at this type of intelligence measuring it can never really be accurate ,as people are learning gall the time and there are different types of learning and memory.
I once spoke to a friend of mine a Harley Street specialist who had had a young boy bought to her attention he was classed as autistic but his IQ levels were austounding ,and his attention to detail of achitecture,was well in advance for his tender years , but at the same time this boy was unable at that point in time to read or write , .
Now if you take this example , then many people who might be classed as having learning difficulties , may have High IQs in certain areas , some of the most dangerous people can be extremely intelligent , but not for the right reason what would you class them as?

[link to vaccinenewsdaily.com]

One doctor in Western Ukraine was quoted as saying the following about what the lungs of people who have died from this flu look like....

"We have carried out post mortems on two victims and found their lungs are as black as charcoal. They look like they have been burned. It’s terrifying."

This frightening thing is that these reports sound chillingly similar to descriptions of how people died from the Spanish flu back in 1918. That horrific flu outbreak killed somewhere between 50 and 100 million people worldwide, and it is regarded as the worst flu pandemic in modern times.

Read the following description of the 1918 Spanish flu from Wikipedia and compare it to the reports above. Does it not sound similar to what is now happening in Ukraine?....

"One of the most striking of the complications was hemorrhage from mucous membranes, especially from the nose, stomach, and intestine. Bleeding from the ears and petechial hemorrhages in the skin also occurred."

The truth is that the similarities are too striking to ignore. The Spanish flu was also an "H1N1" flu. It also killed people by destroying the lungs and filling them with blood just like the current mutant strain in Ukraine is doing. Just check out how Wikipedia describes the horrific deaths that were caused by the 1918 Spanish flu....

The majority of deaths were from bacterial pneumonia, a secondary infection caused by influenza, but the virus also killed people directly, causing massive hemorrhages and edema in the lung.

If this mutant strain even kills a small fraction of the people that the Spanish flu killed then this will almost certainly be the biggest news story of 2010.

In fact, there are disturbing indications that this mutant flu is already spreading.....

*It has been reported that almost 17 percent of the population of Norway has now contracted the flu. Considering the reports from Norway at the beginning of this article, that is a very sobering statistic.

*There has just been a very sudden surge in swine flu deaths in Ontario, Canada. In fact, there is one report that 24 residents of Ontario recently died from the flu in just a 72 hour period.

*It has also been reported that there are nearly a quarter of a million people seriously ill with the H1N1 swine flu in Belarus, and there are unconfirmed reports that patients in Belarus are dying the exact same kind of horrible deaths from the H1N1 swine flu that we are seeing in Ukraine.

*In addition, a national H1N1 swine flu pandemic has been officially declared by the Health Ministry in Bulgaria. Symptoms of the H1N1 swine flu in Bulgaria include temperatures of over 40 degrees Celsius, severe pain in the bones and muscles, coughing, and the quick development of pneumonia.

*Also, in a very disturbing development, a Tamiflu resistant strain of the H1N1 swine flu has now shown up in Wales.

[link to origem.info]

[link to www.ncbi.nlm.nih.gov]
here I am looking for patterns in flu outbreaks
and similarities in the flu viruses from year to year

[link to www.ncbi.nlm.nih.gov]

1930

[link to www.youtube.com]

completely off subject but amazing hope you enjoy

ttp://www.recombinomics.com/News/11281201/Betacoronavirus_Mec​ca.html

this is much more widespread than we are being informed about

Date: Sat 15 Sep 2012
From: Ali Mohamed Zaki <[email protected]> [edited]


A new human coronavirus was isolated from a patient with pneumonia by Dr Ali Mohamed Zaki at the Virology Laboratory of Dr Soliman Fakeeh Hospital Jeddah Saudi Arabia.

The virus was isolated from sputum of a male patient aged 60 years old presenting with pneumonia associated with acute renal failure. The virus grows readily on Vero cells and LLC-MK2 cells producing CPE in the form of rounding and syncetia formation.


[The clinical isolate] was initially tested for influenza virus A, influenza virus B, parainfluenza virus, enterovirus and adenovirus, with negative results. Testing with a pancoronavirus RT-PCR yielded a band at a molecular weight appropriate for a coronavirus. The virus RNA was tested also in Dr. Ron Fouchier's laboratory in the Netherlands and was confirmed to be a new member of the beta group of corononaviruses, closely related to bat coronaviruses. Further analysis is being carried out in the Netherlands.

The Virology Laboratory at the Dr Fakeeh Hospital will be happy to collaborate with others in studies of this virus.

--
Ali Mohamed Zaki
Professor of Microbiology
Dr Fakeeh hospital Jeddah Saudi Arabia
<[email protected]>

Colchester's growth was punctuated by outbreaks of epidemic disease. The years 1514, 1545, 1557-9, 1569-70, 1586-8, 1597, 1603-4, 1625-6, 1631, 1651, 1665-6, and 1679 had particularly high mortality. (fn. 8) The high mortality of 1557-9 was probably caused by the national epidemic of influenza and typhus in those years, (fn. 9) while that of 1597 was possibly due to either famine or disease induced by malnutrition, the result of four successive years of high grain prices. (fn. 10) Plague appears to have been responsible for most of the other years of high death rate, and was active in the town at other times, producing peaks of mortality in particular parishes. St. Botolph's, for instance, experienced additional years of high mortality in 1578, 1583, and 1610-11, St. James's in 1580, Lexden in 1595, and St. Leonard's in 1638-9. The frequency with which the poor parish of St. Botolph experienced such crises demonstrates the close relationship between poverty and epidemic disease. (fn. 11) None of the epidemics was capable of stemming the town's growth. Although plague was a frequent visitor to the town, only in 1597, 1603-4, and 1625-6 did mortality reach double the average level for a sample of parishes representing the town as a whole, and under 10 per cent of total mortality in the early 17th century was due to the additional deaths that such crises produced.

Medical Officer reports on the epidemic of influenza, which has been of world-wide diffusion. It broke out in Russia in 1889, and reached England in December. In January it prevailed all over Cardiff, where it attacked 5 per cent. of the population. The symptoms were fever, followed by profuse perspiration, pains in the head and limbs, extreme prostration, catarrh and (in neglected cases) bronchitis and pneumonia.

Some idea may be formed as to the rapidity with which ecclesiastical changes were wrought in the system of the English Church when we add that whereas in 1556 the sum of 11s. was paid to one Clerke "for making thymage (sic) of St. Margaret," in 1559 we find entries of 2s. 8d., of 1s., and of 1s. to John Rial for "taking down the Roode Mary and John," for "taking down the tabil (sic), or the high altar," and for "cleaving and sawing the Rood Mary and John." It may be noted also that the large sum of 1s. was charged and paid "for ringing at the beheading of the Queen of Scotts." In 1563, a plague similar to the influenza visited Westminster, and the inhabitants were compelled to perform quarantine. Under this year there is an entry as follows:—"1563. Item.—To the paynter of Totehill Street for payntinge of certeyn blew crosses to be fyxed upon sundrie houses infected, vj."

note an influenza similar to the plague 1563 quarantine.

The third book gives baptisms and burials from 1774 to 1813. These fill up about one-third of the book, and the rest of it is practically a journal of 'remarkable occurrences under Crosbie Morgill, collated to the rectory in 1830.' He tells how the parish clerk was suspended for liquor, how the machinery riots of 1830 told on the nerves of the parishioners, how the cholera visited the neighbouring villages in 1832, and how influenza began as a 'national judgment' in 1837. The marriages from 1784 to 1812 are given in a separate book.

Only six years later deaths in Hull occurred at twice the normal rate, apparently as a result of an epidemic of influenza, but for 20 years after 1582 the town was free of such outbreaks. In 1602 the plague struck again and seems to have lasted intermittently for two years, by which time the corporation had begun to build pest-houses in Myton Carr and to remove infected persons to them. Deaths again increased sharply: 210 were registered in 1602, almost double the usual number, and of these no fewer than 98 were buried at Holy Trinity from July to September. In the following year 185 deaths were recorded, despite attempts to minimize the infection by excluding ships, sailors, and goods from other plague-stricken places. (fn. 571)


searching through historical texts there appears to be some correlation between the place and influenza outbreaks ,

he situation remained fairly stable until negotiations began with the Coventry and Warwickshire Hospital in 1927-9 for the sale of the fever hospital. Scarlet fever and diphtheria were still the main diseases although there had been serious influenza epidemics in 1918, 1925, and 1929. In 1930 the hospital, with a staff of 41, dealt with 622 cases. (fn. 33) The old hospital was sold and the present hospital, situated in Whitley at the junction of London Road and Humber Road, was opened in 1934. The architect was Stanley Atkinson of the London firm of Wimperis, Simpson & Guthrie. The hospital provided accommodation for 148 beds.

[link to link.springer.com]